Heart failure etiology impacts survival of patients with heart failure

Pecini, Redi; Møller, Daniél Vega; Torp‐Pedersen, Christian; Hassager, Christian; Køber, Lars

doi:10.1016/j.ijcard.2010.01.011

Cited by 50 publications

(50 citation statements)

References 31 publications

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“…22, 23 Ischemic heart disease was present in 32.1% of the present patients (it should be noted that patients with acute coronary syndrome were excluded from the study); this prevalence was similar to that in the ATTEND registry study currently underway in Japan. 24 In patients with AHFS, high left ventricular diastolic pressure may induce subendocardial ischemia, which may increase the rate of progression of myocardial damage.…”

Section: Discussionsupporting

confidence: 76%

Effects of Intravenous Nicorandil on the Mid-Term Prognosis of Patients With Acute Heart Failure Syndrome

Ishihara

Koga

Kaseda

et al. 2012

Circ J

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Section: Discussionsupporting

confidence: 76%

Effects of Intravenous Nicorandil on the Mid-Term Prognosis of Patients With Acute Heart Failure Syndrome

Ishihara

Koga

Kaseda

et al. 2012

Circ J

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“…In the definition the etiology of HF, patients with a history of prior myocardial infarction or coronary intervention, either coronary artery bypass graft surgery or percutaneous coronary intervention were consider as ischemic heart disease. Patients with a history of chest pain who had pathologic Q waves on the electrocardiogram and/or dyskinetic areas on the echocardiogram were also included in this group (20). Dilated cardiomyopathy group comprised patients with dilatation of the left ventricle when another distinct etiology had not been found despite routine workup, which would always have included evaluation for the presence of ischemic heart disease (20).…”

Section: Methodsmentioning

confidence: 99%

“…Patients with a history of chest pain who had pathologic Q waves on the electrocardiogram and/or dyskinetic areas on the echocardiogram were also included in this group (20). Dilated cardiomyopathy group comprised patients with dilatation of the left ventricle when another distinct etiology had not been found despite routine workup, which would always have included evaluation for the presence of ischemic heart disease (20). Patients with severe valvular disease were excluded in this study.…”

Section: Methodsmentioning

confidence: 99%

The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death

Lin

Chen²,

et al. 2010

Clinical Chemistry and Laboratory Medicine

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Background Cardiac extra-cellular matrix (ECM) fibrosis plays an important role in the pathophysiology of heart failure (HF). It may provide electrical heterogeneity and substrate for arrhythmogenicity, which may cause sudden cardiac death (SCD). Methods Twenty-one Patients with HF manifestations, and left ventricular ejection fraction (LVEF) ≤ 50% were enrolled. The median age was 62 years and median LVEF was 33 %. Time- and frequency-domain analysis of heart rate variability (HRV) on 24-hour ambulatory electrocardiography recording was assessed. Serum markers of ECM turnover including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9), and tissue inhibitor of metalloproteinase 1 (TIMP-1) were analyzed. Results The serum PIIINP level was significantly correlated with standard deviation of all normal RR intervals (SDNN) (r=−0.722, p=<0.001), percentage of adjacent NN interval differences >50 ms (pNN50) (r=−0.528, p=0.014), percentage of adjacent NN interval differences >20 ms (pNN20) (r=−0.545, p=0.002), very low frequency (VLF) (r=−0.490, p=0.024), low frequency (LF) (r=−0.491, p=0.024), high frequency (HF) (r=−0.513, p=0.018). PINP, MMP-2, 9, TIMP-1 were not correlated with time- and frequency-domain analysis of HRV. Conclusions PIIINP was significantly correlated with time- and frequency-domain analysis of HRV in HF patients. PIIINP is a potential serological marker to evaluate cardiac autonomic control and risk of SCD in HF patients.

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“…Patients with acute coronary syndrome were not eligible for the study nor were patients with atrioventricular block grade II or III, clinically significant hepatic (severe cirrhosis) or renal disease (serum creatinine > 300 μmol/l), stroke within 1 month, or any illness or disorder other than heart failure which could preclude participation or severely limit survival. The local investigators classified the patients in different groups according to etiology as described previously[18]. The study conforms to the principles outlined in the Declaration of Helsinki and was approved by The Danish Board of Health as well as the Central Danish Ethics Committee.…”

Section: Methodsmentioning

confidence: 99%

Hereditary Hemochromatosis (HFE) genotypes in heart failure: Relation to etiology and prognosis

et al. 2010

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BackgroundIt is believed that hereditary hemochromatosis (HH) might play a role in cardiac disease (heart failure (HF) and ischemia). Mutations within several genes are HH-associated, the most common being the HFE gene. In a large cohort of HF patients, we sought to determine the etiological role and the prognostic significance of HFE genotypes.MethodsWe studied 667 HF patients (72.7% men) with depressed systolic function, enrolled in a multicentre trial with a follow-up period of up to 5 years. All were genotyped for the known HFE variants C282Y, H63D and S65C.ResultsThe genotype and allele frequencies in the HF group were similar to the frequencies determined in the general Danish population. In multivariable analysis mortality was not predicted by C282Y-carrier status (HR 1.2, 95% CI: 0.8-1.7); H63D-carrier status (HR 1.0, 95% CI: 0.7-1.3); nor S65C-carrier status (HR 1.2, 95% CI: 0.7-2.0). We identified 27 (4.1%) homozygous or compound heterozygous carriers of HFE variants. None of these carriers had a clinical presentation suggesting hemochromatosis, but hemoglobin and ferritin levels were higher than in the rest of the cohort. Furthermore, a trend towards reduced mortality was seen in this group in univariate analyses (HR 0.4, 95% CI: 0.2-0.9, p = 0.03), but not in multivariate (HR 0.5, 95% CI: 0.2-1.2).ConclusionHFE genotypes do not seem to be a significant contributor to the etiology of heart failure in Denmark. HFE variants do not affect mortality in HF.

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Heart failure etiology impacts survival of patients with heart failure

Cited by 50 publications

References 31 publications

Effects of Intravenous Nicorandil on the Mid-Term Prognosis of Patients With Acute Heart Failure Syndrome

Effects of Intravenous Nicorandil on the Mid-Term Prognosis of Patients With Acute Heart Failure Syndrome

The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death

Hereditary Hemochromatosis (HFE) genotypes in heart failure: Relation to etiology and prognosis

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