Heart failure having little effect on the progression of Parkinson's disease: Direct evidence from mouse model

Xu, Jing; Bu, Liping; Huang, Li; Yang, Yufang; Yu, Mei; Liu, Jie; Wang, Pan; Huang, Dongping; Bai, Xiaochen; Ma, Yuanyuan; Huang, Fang; Zou, Yunzeng; Ge, Junbo

doi:10.1016/j.ijcard.2014.09.157

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…Dopamine and DOPAC levels were assessed with the Agilent 1200 series neurotransmitter analyzer (Agilent Technologies, Santa Clara, CA, USA) consisting of a G1367B autosampler, a G1312A binary pump, a G1322A degasser, the ANTEC DECRARD SDC electrochemical detector (Antec, Zoeterwoude, The Netherlands) equipped with a Sencell with a 2-mm glassy carbon working electrode, and an Acclaim C18 column (2.2 lm, 2.1 3 100 mm; Thermo Fisher Scientific, Waltham, MA, USA). This system has worked very well with high reliability, as demonstrated by previous studies, [55][56][57] and is sensitive enough to detect significant changes in mouse retinal DA/DOPAC levels. Separations were performed at a flow rate of 0.2 mL/min using a mobile phase of PB, containing (in mM) 0.05 EDTA, 1.7 orthosilicic acid (OSA), 90.0 Na 2 HPO 4 , 50.0 citric acid, and 5% acetonitrile, with the detection cells set at þ700 mV.…”

Section: Analysis By Hplcmentioning

confidence: 68%

The Role of Retinal Dopamine in C57BL/6 Mouse Refractive Development as Revealed by Intravitreal Administration of 6-Hydroxydopamine

Qian

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Section: Analysis By Hplcmentioning

confidence: 68%

The Role of Retinal Dopamine in C57BL/6 Mouse Refractive Development as Revealed by Intravitreal Administration of 6-Hydroxydopamine

Qian

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…At this time point, MPTP induces widespread microglial activation in the nigrostriatal pathway, as indicated by an increase in the number and size of Iba1 + microglial cells and morphological changes, such as hypertrophy [ 50 , 59 ]. At 7 days after injection, a remarkable number of microglial cells were still activated in the SN of young [ 35 , 57 ] and old mice [ 60 ]. One day after MPTP treatment, the striatal levels of the GFAP protein did not change, suggesting the astrocytes might still be at the resting state [ 58 ].…”

Section: Early Effects Of Mptp On the Nigrostriatal Pathwaymentioning

confidence: 99%

Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease

Huang

Wang

et al. 2017

Parkinson's Disease

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The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's disease (PD) are well established. However, the details regarding the causes of the disease and its course are much less clear. Animal models have significantly enriched our current understanding of the progression of this disease. Among various neurotoxin-based models of PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model is the most commonly studied model. Here, we provide an overview of the dynamic changes in the nigrostriatal pathway in the MPTP mouse model of PD. Pathophysiological events, such as reductions in the striatal dopamine (DA) concentrations and levels of the tyrosine hydroxylase (TH) protein, depletion of TH-positive nerve fibers, a decrease in the number of TH-positive neurons in the substantia nigra pars compacta (SNpc), and glial activation, are addressed. This article will assist with the development of interventions or therapeutic strategies for PD.

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“…The MI operation was performed in the mice according to the established protocol . In brief, the mice were anesthetized with isoflurane, intubated, and cannulated to a rodent ventilator (Type 7025; Harvard Apparatus, March‐Hugstetten, Germany).…”

Section: Methodsmentioning

confidence: 99%

Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression

Wang

et al. 2019

The FEBS Journal

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Epidemiological and clinicopathological studies indicate that there is a high risk for chronic heart failure (CHF) in patients suffering from neuropsychiatric disorders, such as depression. However, it is unclear whether CHF causes depression, and the underlying mechanisms of this association remain largely unknown. In this study, mice with myocardial infarction and CHF were used to investigate behavioral alterations as well as changes in the brain‐heart axis. During the first 6 months, abnormalities in neuropsychiatric behaviors were detected in mice with CHF. Using the sucrose preference test, a 9 months course of CHF resulted in two subgroups: mice with a significant decrease in sucrose preference, defined herein as “susceptible” (Sus), and mice with a normal sucrose preference, defined herein as “resilient.” Compared to the resilient and sham‐operated animals, the Sus mice displayed imbalances in glutamate transmission and hypothalamic–pituitary–adrenal axis activation, abnormal synaptic plasticity, and increased inflammatory responses. Furthermore, abnormal kynurenine metabolism was detected in Sus mice. Our results suggest that long‐term CHF increases inflammatory responses in the central nervous system and leads to depression in Sus mice.

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Heart failure having little effect on the progression of Parkinson's disease: Direct evidence from mouse model

Cited by 7 publications

References 10 publications

The Role of Retinal Dopamine in C57BL/6 Mouse Refractive Development as Revealed by Intravitreal Administration of 6-Hydroxydopamine

The Role of Retinal Dopamine in C57BL/6 Mouse Refractive Development as Revealed by Intravitreal Administration of 6-Hydroxydopamine

Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease

Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression

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