Heart Failure in NCVC Jakarta and 5 hospitals in Indonesia

Siswanto, Bambang Budi; Radi, Basuni; Kalim, Harmani; Santoso, Anwar; Suryawan, Rurus; Erwinanto,; Antono, Eko; Santoso, Teguh

doi:10.1016/j.cvdpc.2010.03.005

Cited by 25 publications

(35 citation statements)

References 7 publications

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“…In contrast, amiodarone and heparin are administered parenterally and mostly used in patients with severe conditions. However, the rate of overall use of ACEIs or ARBs found in this study at 75 % is higher compared to the rate reported by Callender et al [ 21 ] in their systematic review on HF in low-middle income countries and Siswanto et al [ 22 ] in their study on HF in Indonesia, 57 % and 68 %, respectively.…”

Section: Discussioncontrasting

confidence: 85%

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Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure

Saepudin

Ball

Morrissey

2015

BMC Cardiovasc Disord

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BackgroundTo date, the majority of studies on hyponatremia focussed on hyponatremia at admission, and came from developed countries. This study aimed to identify the prevalence of hyponatremia during hospitalization in patients hospitalized for HF and its association with in-hospital mortality.MethodsThis was an observational study using retrospective data from patients’ records between 2010–2013. It focused on those patients carrying an ICD-10 code of 150.0(Congestive Heart Failure) as their primary diagnosis.Hyponatremia during hospitalization was defined as serum sodium level lower than 135 mEq/L obtained from a blood chemistry measurement on the next days after admission. Patients’ characteristics were examined and the association between hyponatremia during hospitalization and in-hospital mortality was analyzed.ResultsAmong 464 patients hospitalized for HF, hyponatremia during hospitalization was observed in 22 % of patients with 44 % of this group had normal serum sodium level on admission.Hyponatremia during hospitalization was associated with lower blood pressure on admission, both systolic and diastolic, peripheral oedema, ascites and fatigue. Patients having history of hospitalization for cardiac diseases and renal failure were higher in patients developing hyponatremia during hospitalization. In this group, amiodarone, heparin, insulin and antibiotics were administered more frequently. Factors potentially increase the risk of hyponatremia during hospitalization include history of fatigue (OR = 3.23, 95 % CI 1.79–5.82), presence of ascites (4.14, 1.84–9.31), and administration of heparin (3.85, 1.78–8.31) and antibiotics (3.08, 1.71–5.53). Length of hospital stay was significantly longer in patients with hyponatremia during hospitalization and in-hospital mortality was also higher compared to non-hyponatremic patients, 7.7 % and 29.1 %, respectively.ConclusionThis study found that the prevalence of hyponatremia during hospitalization in patients hospitalized for HF was almost the same as hyponatremia on admission and administration of heparin and antibiotics can potentially worsen hyponatremia during hospitalization. In this study population, hyponatremia during hospitalization was found to be associated with in-hospital mortality.

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Section: Discussioncontrasting

confidence: 85%

“…The overall in-hospital mortality rate found in this study is 11 % and this is higher than the average of in-hospital mortality rates reported by Siswanto, et al in their report on behalf of The Acute Decompensated Heart Failure National Registry (ADHERE) research team in Indonesia at 6.7 % [ 22 ].…”

Section: Discussioncontrasting

confidence: 56%

Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure

Saepudin

Ball

Morrissey

2015

BMC Cardiovasc Disord

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“…2 Di Indonesia sendiri berdasarkan studi Acute Decompensated Heart Failure Registry (ADHERE) yang mengikutsertakan 5 rumah sakit rujukan nasional ditemukan 1687 orang yang dirawat dengan gagal jantung akut pada tahun 2006 dengan angka kematian di rumah sakit sebesar 6,7%. 3 Gagal jantung akut berasal dari gangguan kardiak akut ataupun subakut yang mengakibatkan kongesti pulmoner. Gagal jantung akut dapat berupa gagal jantung awitan baru (de novo) ataupum konsekuensi dari dekompensasi akut gagal jantung kronik yang biasanya dipresipitasi oleh beberapa faktor seperti infeksi, hipertensi tak terkontrol, gangguan irama atau ketidakpatuhan terhadap obat.…”

Section: Pendahuluanunclassified

Disfungsi Mitokondria pada Gagal Jantung Akut

Ilhami

2020

JKK

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AbstrakMitokondria merupakan organel penting yang bermanfaat dalam homeostasis tubuh tidak hanya pada pembentukan ATP saja tetapi juga memiliki fungsi lain seperti mengatur pensinyalan sel dengan memodulasi keadaan redoks, memberikan cofactor untuk reaksi biokimia dan menghasilkan ligand untuk transduksi sinyal. Pada keadaan gagal jantung terjadi gangguan mitokondria yang diakibatkan oleh berbagai mekanisme meliputi hiperasetilasi protein, gangguan homeostasis kalsium, pembentukan spesies oksigen reaktif dan peningkatan respons inflamasi. Kata kunci: mitokondria, gagal jantung, mekanisme gangguan mitokondria Kata kunci : mitokondria, gagal jantung akut AbstractMitochondria are important organelles that are useful in body homeostasis not only in the formation of ATP but also have other functions such as regulating cell signaling by modulating the redox state, providing cofactors for biochemical reactions and producing ligands for signal transduction. In conditions of heart failure mitochondrial disorders are caused by various mechanisms including protein hyperacetylation, disorders of calcium homeostasis, formation of reactive oxygen species and increased inflammatory response Keyword: mitochondria, heart failure, mechanism of mitochondrial dysfunction

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“…In the developing world, 1 in 5 people are expected to develop HF [1]. About 17–45% of individuals admitted to the hospital with HF die within 1 year, and most within 5 years [2-4]. Thus, it is paramount to address prevention and risk factors to decrease the risk of incident HF.…”

Section: Introductionmentioning

confidence: 99%

Statin Lipophilicity and the Risk of Incident Heart Failure

et al. 2020

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Background: To compare the risk of incident heart failure (HF) between initiators of hydrophilic and lipophilic statins. Methods: Using claims data for commercial health insurance program enrollees in the USA (2005–2014), we identified new initiators of hydrophilic or lipophilic statins. Follow-up for the primary outcome of incident HF began after a lag period of 1 year after statin initiation. The outcome was defined as 1 inpatient or 2 outpatient diagnosis codes for HF and the use of loop diuretics. Propensity scores (PS) were used to account for confounding. Hazard ratios (HR) for incident HF were computed separately for low and high-intensity statin users, and then pooled to provide dose-adjusted effect estimates. Results: A total of 7,820,204 patients met all our inclusion criteria for statin initiation (hydrophilic and lipophilic statins). Mean age was 58 years, 40% had hypertension, and 23% had diabetes mellitus. After PS matching, there were 691,584 patients in the low-intensity statin group and 807,370 patients in the high-intensity statin group. After a median follow-up of 725 days (IQR 500–1,153),there were 8,389 cases of incident HF (incidence rate 4.5/1,000 person years, 95% confidence interval [CI] 4.4–4.6). The unadjusted HR for the risk of HF was 0.77 (95% CI 0.76–0.79) and the pooled adjusted HR for incident HF after PS matching was 0.94 (95% CI 0.90–0.98) for hydrophilic versus lipophilic statins. The HR for incident HF was 1.06 (95% CI 1.00–1.12) for hydrophilic versus lipophilic statins for the low-intensity statin group and 0.82 (95% CI 0.78–0.87) for the high-intensity statin group. In subgroup analyses, a similar trend persisted for those younger and older than 65 years and when comparing rosuvastatin with atorvastatin. Conclusion: In this observational cohort study, hydrophilic statins were associated with a modest risk reduction in incident HF as compared to lipophilic statins. Future research replicating these findings in different populations is recommended.

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Heart Failure in NCVC Jakarta and 5 hospitals in Indonesia

Cited by 25 publications

References 7 publications

Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure

Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure

Disfungsi Mitokondria pada Gagal Jantung Akut

Statin Lipophilicity and the Risk of Incident Heart Failure

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