Heart Failure Prevalence, Incidence, and Mortality in the Elderly With Diabetes

Abstract

OBJECTIVE—The goal of this study was to determine heart failure prevalence and incidence rates, subsequent mortality, and risk factors for heart failure among older populations in Medicare with diabetes. RESEARCH DESIGN AND METHODS—We used a national 5% sample of Medicare claims from 1994 to 1999 to perform a population-based, nonconcurrent cohort study in 151,738 beneficiaries with diabetes who were age ≥65 years, not in managed care, and were alive on 1 January 1995. Prevalent heart failure was defined as a diagnosis of heart failure in 1994; incident heart failure was defined as a new diagnosis in 1995–1999 among those without prevalent heart failure. Mortality was assessed through 31 December 1999. RESULTS—Heart failure was prevalent in 22.3% in 1994. Among individuals without heart failure in 1994, the heart failure incidence rate was 12.6 per 100 person-years (95% CI 12.5–12.7 per 100 person-years). Incidence was similar by sex and race and increased significantly with age and diabetes-related comorbidities. The adjusted hazard of incident heart failure increased for individuals with the following: metabolic complications of diabetes (a proxy for poor control and/or severity) (hazards ratio 1.23, 95% CI 1.18–1.29), ischemic heart disease (1.74, 1.70–1.79), nephropathy (1.55, 1.45–1.67), and peripheral vascular disease (1.35, 1.31–1.39). Over 60 months, incident heart failure among older adults with diabetes was associated with high mortality—32.7 per 100 person-years compared with 3.7 per 100 person-years among those with diabetes who remained heart failure free. CONCLUSIONS—These data demonstrate alarmingly high prevalence, incidence, and mortality for heart failure in individuals with diabetes. Prevention of heart failure should be a research and clinical priority.

MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice

“…Heart failure in diabetic individuals has an alarmingly high prevalence, incidence and mortality, yet the underlying pathogenesis of DCM remains unclear [3][4][5]16]. The major findings from our current study revealed decreased myocardial glucose uptake and impaired cardiac diastolic and systolic function in diabetic mice.…”

Calcium, Phosphorus, Parathyroid Hormone, and Cardiovascular Disease in Hemodialysis Patients: The USRDS Waves 1, 3, and 4 Study

“…Nonfatal and fatal cardiovascular events were studied, as opposed to purely cause-specific mortality, because the latter has been found to be relatively inaccurate in other studies (25). Several studies have found high specificity but low sensitivity for claims data for many diagnoses, including ischemic heart disease and stroke (26,27), so true event rates are likely to be underestimated. If one hypothesizes that abnormalities of calcium-phosphorus homeostasis cause death via cardiovascular mechanisms alone, all-cause mortality may also underestimate event rates.…”

ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD – Summary

“…Studies in heart failure populations reveal a prevalence of T2DM from 12-30%, rising with age. 270,271 In the Framingham study, the age-adjusted relative risk of heart failure in patients with T2DM (age 45-74 years) was 2.2 for men and 5.3 for women. 272 The high incidence of heart failure in patients with T2DM was confirmed in the National Health and Nutrition Examination Survey, with an HR of 1.85 (95% CI 1.51-2.28) in T2DM compared with non-DM.…”