Heart microvessels and aortic endothelial cells express the 15 kDa heart-type fatty acid-binding proteins

Antohe, Felicia; Popov, Doina; Rădulescu, Luminiţa; Simiónescu, N; Börchers, Torsten; Spener, Friedrich; Simionescu, Maya

doi:10.1016/s0171-9335(98)80022-8

Cited by 24 publications

(18 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite recent advances in understanding LCFA transport, the route and detailed mechanisms of how FA transport through the endothelium is conferred remains unresolved (FIGURE 3) (114, 115). In addition to the earlier mentioned FATP3 and FATP4, also CD36, FABP3, FABP4, FABP5, and FABP PM are expressed by the vascular endothelium (4,17,30,43,82,118). …”

Section: Lcfa Transport Proteinsmentioning

confidence: 83%

“…They are expressed in numerous tissues, with a direct positive correlation to the lipid metabolizing capacity of the tissue. To date, three FABPs have been shown to be expressed by ECs: the heart-type Fabp3 (also known as H-FABP and Mdgi), the adipose-type Fabp4 (also known as A-FABP and aP2), and epidermaltype Fabp5 (also known as E-FABP and mal1) (4,30,82,118). Fabp3 is expressed by a wide range of cells, including cardiomyocytes, ECs, renal epithelial Signalling: To ECs in heart, muscle, BAT, pancreas, WAT and kidney, as well as to neurons in brain Induced deletion of endothelial NRP1 expression: Lower FATP expression and less FA-uptake in heart and muscle.…”

Section: The Fabpsmentioning

confidence: 99%

“…Fabp5 is expressed in the endothelium of placenta, heart, skeletal muscle, small intestine, lung, and renal medulla, in the epidermis of lung, as well as by tissue cells of several organs such as heart, skeletal muscle, and lung (82,107). The specific endothelial role of FABPs in FA trafficking is difficult to determine due to the overlapping expression pattern of the FABP family members (4,30,82,107).…”

Section: The Fabpsmentioning

confidence: 99%

“…FABP PM is larger (ϳ40 kDa) than the small cytosolic FABPs and is associated with biological membranes found both in mitochondria and on the extracellular side of cardiomyocytes, myocytes, hepatocytes, adipocytes, and ECs (4,17,41). FABP PM at the PM associates with CD36, where its primary role seems to be to assist CD36 in the binding and transport of FAs (41).…”

Section: Fapb Pmmentioning

confidence: 99%

See 3 more Smart Citations

Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

et al. 2013

View full text Add to dashboard Cite

Dietary lipids present in the circulation have to be transported through the vascular endothelium to be utilized by tissue cells, a vital mechanism that is still poorly understood. Vascular endothelial growth factor B (VEGF-B) regulates this process by controlling the expression of endothelial fatty acid transporter proteins (FATPs). Here, we summarize research on the role of the vascular endothelium in nutrient transport, with emphasis on VEGF-B signaling.

show abstract

Section: Lcfa Transport Proteinsmentioning

confidence: 83%

Section: The Fabpsmentioning

confidence: 99%

Section: The Fabpsmentioning

confidence: 99%

Section: Fapb Pmmentioning

confidence: 99%

See 2 more Smart Citations

Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

et al. 2013

View full text Add to dashboard Cite

show abstract

“…We also speculate that serum H-FABP is possibly derived from the aortic wall, based upon our present results and a previous report that demonstrated the existence of H-FABP in the murine aorta. 13 Previous reports have demonstrated the effectiveness of the myoglobin/H-FABP ratio in discriminating between damaged cardiac and skeletal muscle. 12,14 Furthermore, Van Nieuwenhoven et al reported that the myoglobin/H-FABP ratio in the heart was appropriately 4.5 compared with between 22 and 73 in skeletal muscle, depending on the type of skeletal muscle tissue.…”

Section: Discussionmentioning

confidence: 99%

Serum Heart-Type Fatty Acid-Binding Protein Concentration Positively Correlates With the Length of Aortic Dissection

Hara

Negoro

Nishimoto

et al. 2005

Circ J

View full text Add to dashboard Cite

Inversely related expression of epidermal- and heart-type fatty acid binding proteins during myogenic differentiation of C2C12 myoblasts

Bleck

Buhlmann

Hohoff

et al. 2002

Eur. J. Lipid Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Inversely related expression of epidermal-and heart-type fatty acid binding proteins during myogenic differentiation of C2C12 myoblastsFollowing our report that heart-type (H-) fatty acid binding protein (FABP) was strongly up-regulated in differentiating myotubes, we examined the role of FABP and their effect on oleic acid uptake in the differentiation of mouse C2C12 myoblasts to myotubes in vitro. A second epidermal-type (E-) FABP is already expressed in the myoblast stage and is down-regulated at the onset of myogenic differentiation. This down-regulation is paralleled by that of β-actin, whereas mRNA expression of myogenic transcription factors and of H-FABP increases. These findings were verified at the protein level, which indicated that a basal level of FABPs, independent of the type, is always present during differentiation. Both FABPs were identified by their intracellular binding of oleic acid. This may explain that the change in oleic acid uptake into C2C12 cells at different stages of differentiation was negligible. Yet, the transition from E-FABP expressing myoblasts to H-FABP expressing myotubes was accompanied by a shift in preferential incorporation of oleic acid from triacylglycerols to phospholipids, perhaps necessary for terminal differentiation. The comparison of the expression of H-FABP with that of master myogenic transcription factors demonstrates that this fatty acid binding protein is not involved in the initiation of differentiation. The combination of a particular FABP and the cell in which it is expressed determines the fatty acid uptake.

show abstract

Heart microvessels and aortic endothelial cells express the 15 kDa heart-type fatty acid-binding proteins

Cited by 24 publications

References 36 publications

Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

Serum Heart-Type Fatty Acid-Binding Protein Concentration Positively Correlates With the Length of Aortic Dissection

Inversely related expression of epidermal- and heart-type fatty acid binding proteins during myogenic differentiation of C2C12 myoblasts

Contact Info

Product

Resources

About