Heart-rate effects on canine left-ventricular end-diastolic compliance measured by two-dimensional ultrasound

Haasler, George B.; Rodigas, Paul C.; Wei, Jeng; Spotnitz, Henry M.

doi:10.1016/0022-4804(84)90089-1

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…Among these, heart rate did not change significantly after CPB; our data indicate minor effects of heart rate variability on diastolic properties. 21 A limited and inconsistent range of EDP for our patients limited comparisons across the group and dictated use of a simple exponential equation for curve-fitting. Our study is also not large enough to identify differences among subgroups (dominant ventricle, specific diagnoses, etc), or to perform multivariate analysis incorporating other potential risk factors for prolonged pleural effusions.…”

Section: Discussionmentioning

confidence: 99%

Ventricular Diastolic Stiffness Predicts Perioperative Morbidity and Duration of Pleural Effusions After the Fontan Operation

et al. 2006

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Background-We validated the clinical relevance of ventricular stiffness by examining surgical morbidity in children with univentricular hearts undergoing Fontan operation. We hypothesized that ventricular stiffness affects Fontan morbidity, particularly duration of pleural effusions. Methods and Results-Sixteen children with right ventricular (RV) (n ϭ11) or left ventricular (LV) (n ϭ5) dominance were studied intraoperatively at a median age of 3.3 years (1.8 to 5.1). Transesophageal long-axis echocardiograms and ventricular pressure by micromanometer provided end-diastolic pressure (P) area (A) relations during initiation and conclusion of cardiopulmonary bypass. Curve fitting to the equation Pϭ␣e ␤A defined the ventricular stiffness constant, ␤. Changes in ␤ and clinical correlations were examined. Ventricular stiffness increased after bypass in patients with complete pre-bypass and post-bypass data (n ϭ11, Pϭ0.023, mixed models methodology). Pre-bypass ␤ correlated well with duration of chest tube (CT) drainage (rϭ0.90, n ϭ16), net perioperative fluid balance (rϭ0.71, nϭ14), and length of stay (LOS) (rϭ0.81, n ϭ16). CT duration and LOS also correlated significantly with post-bypass ␤ (rϭ0.77 for both, nϭ11), but insignificantly with preoperative catheterization pressures. Conclusions-Intraoperative

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Section: Discussionmentioning

confidence: 99%

Ventricular Diastolic Stiffness Predicts Perioperative Morbidity and Duration of Pleural Effusions After the Fontan Operation

et al. 2006

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“…This increase in mean HR is still within the physiologic range, as we excluded data at time points when the HR is greater than 100 beats per minute by design. It has been shown that modest increase in HR in animals and humans is only associated with a minor change in LV compliance 22,23 . It is unlikely that the physiologic increase in HR over time in our study would have affected our echocardiographic assessment of LV compliance significantly.…”

Section: Discussionmentioning

confidence: 74%

Diastolic Dysfunction After Coronary Artery Bypass Grafting?The Effect of Glucose-Insulin-Potassium Infusion

Tsang

Davidoff

Korach³

et al. 2007

J Cardiac Surgery

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“…Calculations improved with image quality as well as better algorithms for LV end‐diastolic volume (EDV), LVM, and geometry in dogs. Multiple observers blinded to the conditions under which 2‐DE was done validated our calculations [1, 2, 40–48]. LVM measurements proved more accurate and reproducible than measurements of LVEDV despite the fact that LVM is defined by the mathematic difference of calculations of the epicardial and endocardial shells.…”

Section: Myocardial Water Content and LV Massmentioning

confidence: 88%

“…LVM measurements proved more accurate and reproducible than measurements of LVEDV despite the fact that LVM is defined by the mathematic difference of calculations of the epicardial and endocardial shells. The LVM algorithm we developed was also volume‐dependent; LVM increased artifactually with increasing LVEDV [2, 44, 45, 49]. Although the magnitude of this change was relatively small, accuracy was promoted by correcting for differences in LVEDV [49] or by comparing echocardiograms obtained at matched LVEDV [2].…”

Section: Myocardial Water Content and LV Massmentioning

confidence: 99%

Ventricular Function in Surgery for Congenital Heart Disease

Spotnitz

2009

World j. surg.

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BACKGROUND The history of measuring myocardial edema by two-dimensional echocardiography and the pathophysiology of myocardial edema are reviewed. METHODS The relevance of this subject to management of children undergoing corrective surgery for single ventricle physiology and tetralogy of Fallot is reviewed. RESULTS Evidence is presented that myocardial edema is an ongoing clinical problem with relevance to management and outcomes. Methods for measuring mass increases noninvasively in the range of 10-25% with increases in myocardial water content on the order of 2-4% are now well established. CONCLUSIONS These methods and advanced animal models replicating conditions of surgery for cyanotic congenital heart disease set the stage for clinical advances in this important area.

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Heart-rate effects on canine left-ventricular end-diastolic compliance measured by two-dimensional ultrasound

Cited by 12 publications

References 31 publications

Ventricular Diastolic Stiffness Predicts Perioperative Morbidity and Duration of Pleural Effusions After the Fontan Operation

Ventricular Diastolic Stiffness Predicts Perioperative Morbidity and Duration of Pleural Effusions After the Fontan Operation

Diastolic Dysfunction After Coronary Artery Bypass Grafting?The Effect of Glucose-Insulin-Potassium Infusion

Ventricular Function in Surgery for Congenital Heart Disease

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