Heart rate recovery improves after weight loss in overweight and obese women with polycystic ovary syndrome

Thomson, Rebecca L.; Buckley, Jonathan D.; Noakes, Manny; Clifton, Peter M.; Norman, Robert J.; Brinkworth, Grant D.

doi:10.1016/j.fertnstert.2008.12.003

Cited by 20 publications

(19 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In support of our findings, women with PCOS have greater density of ovarian cathecholaminergic nerve fibers (27,53), altered catecholamine metabolism (18), and disturbed HRV (81) and abnormal heart rate recovery (HRR) after exercise test, two indirect markers of autonomic function (20,67,71). Furthermore, PCOS is associated with risk factors thought to be related to altered activity of the sympathetic nervous system, such as hyperinsulinemia, insulin resistance, obesity, and cardiovascular disease (20,31,67,72).…”

Section: Pcos Is Associated With High Sympathetic Nerve Activitysupporting

confidence: 55%

See 1 more Smart Citation

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

Stener-Victorin¹,

Jedel²,

Janson³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

150

166

View full text Add to dashboard Cite

Stener-Victorin E, Jedel E, Janson PO, Sverrisdottir YB. Lowfrequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol 297: R387-R395, 2009. First published June 3, 2009 doi:10.1152/ajpregu.00197.2009We have recently shown that polycystic ovary syndrome (PCOS) is associated with high muscle sympathetic nerve activity (MSNA). Animal studies support the concept that low-frequency electroacupuncture (EA) and physical exercise, via stimulation of ergoreceptors and somatic afferents in the muscles, may modulate the activity of the sympathetic nervous system. The aim of the present study was to investigate the effect of these interventions on sympathetic nerve activity in women with PCOS. In a randomized controlled trial, 20 women with PCOS were randomly allocated to one of three groups: low-frequency EA (n ϭ 9), physical exercise (n ϭ 5), or untreated control (n ϭ 6) during 16 wk. Direct recordings of multiunit efferent postganglionic MSNA in a muscle fascicle of the peroneal nerve before and following 16 wk of treatment. Biometric, hemodynamic, endocrine, and metabolic parameters were measured. Low-frequency EA (P ϭ 0.036) and physical exercise (P ϭ 0.030) decreased MSNA burst frequency compared with the untreated control group. The low-frequency EA group reduced sagittal diameter (P ϭ 0.001), while the physical exercise group reduced body weight (P ϭ 0.004) and body mass index (P ϭ 0.004) compared with the untreated control group. Sagittal diameter was related to MSNA burst frequency (Rs ϭ 0.58, P Ͻ 0.005) in the EA group. No correlation was found for body mass index and MSNA in the exercise group. There were no differences between the groups in hemodynamic, endocrine, and metabolic variables. For the first time we demonstrate that low-frequency EA and physical exercise lowers high sympathetic nerve activity in women with PCOS. Thus, treatment with low-frequency EA or physical exercise with the aim to reduce MSNA may be of importance for women with PCOS. polycystic ovary syndrome; sympathetic nerve activity; testosterone; insulin resistance; metabolic syndrome; cardiovascular disease POLYCYSTIC OVARY SYNDROME (PCOS) is one of the most common female endocrine disorders affecting ϳ10% of women of reproductive age, and is strongly associated with hyperandrogenism and ovulatory dysfunction (8,46). PCOS increases the risk of metabolic disturbances such as abdominal obesity, hyperinsulinaemia, and insulin resistance, which can lead to type 2 diabetes, and dyslipidemia (8, 46), as well as hypertension which may lead to the development of other cardiovascular diseases (35).Despite extensive research, the primary etiology remains unknown, although both environmental and genetic factors are implicated (17). Existing evidence suggests the ovarian theca cells, the major source of androgen production and secretion (22) to play a key role in the etiology. Also, the hypothalamicpituitary axis (50) and defective insulin a...

show abstract

Section: Pcos Is Associated With High Sympathetic Nerve Activitysupporting

confidence: 55%

“…However, in a recent study HRR was shown to be improved after body weight loss in women with PCOS (71).…”

Section: Low-frequency Ea and Physical Exercise Decrease Sympathetic mentioning

confidence: 89%

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

Stener-Victorin¹,

Jedel²,

Janson³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

150

166

View full text Add to dashboard Cite

show abstract

“…Blunted HRR after exercise, a sign of autonomic dysfunction, has been demonstrated to be a strong predictor of all-cause mortality in several studies (Imai et al 1994;Lind and Andren 1999). Moreover, patients with MS and several of its components have been shown to have blunted HRR (Thomson et al 2010). Cardiac autonomic dysfunction and blunted HRR may partly explain increased cardiovascular risk related to the MS.…”

Section: Discussionmentioning

confidence: 98%

The Association of Epicardial Fat Thickness with Blunted Heart Rate Recovery in Patients with Metabolic Syndrome

Şengül¹,

Duman

2011

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Epicardial fat tissue has unique endocrine and paracrine functions that affect the cardiac autonomic system. Epicardial fat thickness (EFT) and blunted heart rate recovery (HRR) are newly identified cardiovascular risk factors in patients with metabolic syndrome (MS). The objective of this study is to evaluate the association between EFT and HRR in patients with MS. Forty patients with MS and 36 healthy controls were included in the study. Echocardiographic EFT and HRR at 1min after exercise termination (HRR-1) are measured and compared between the two groups. HRR-1 equal to or lower than 18 beats is considered as blunted HRR. EFT was increased (7.2 ± 2 vs. 5.6 ± 1.8 mm; p = 0.001) and HRR-1 was significantly reduced in patients with MS compared to control group (21 ± 8 vs. 26 ± 9; p = 0.006). Among the MS patients, subjects with blunted HRR had increased EFT compared to patients without blunted HRR (8.5 ± 2.0 vs. 5.9 ± 1.1 mm, p < 0.001). In multivariate analysis, EFT was the only independent predictor of blunted HRR in patients with MS (95% confidence interval = 1.42-3.87, OR = 2.34, p = 0.001). Furthermore, EFT of equal to or thicker than 5.5 mm was associated with the blunted HRR with 84% sensitivity and 52% specificity (ROC area under curve: 0.84, 95% confidence interval = 0.70-0.96, p < 0.001). In conclusion, EFT is an independent predictor of blunted HRR, a novel cardiovascular risk factor, in patients with MS.

show abstract

“…Studies have shown improvements for women with PCOS in insulin resistance 19, 20, 36, 37 , serum lipids 36, 38 , and cardiovascular disease risk 19, 20, 36, 39 . Additionally, menstrual cycle improvements have been shown following exercise intervention in women with PCOS 19, 36, 40 .…”

Section: Discussionmentioning

confidence: 99%

Potential effects of aerobic exercise on the expression of perilipin 3 in the adipose tissue of women with polycystic ovary syndrome: a pilot study

Covington

Bajpeyi

Moro

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective Polycystic Ovary Syndrome (PCOS) is associated with reduced adipose tissue lipolysis that can be rescued by aerobic exercise. We aimed to identify differences in gene expression of perilipins and associated targets in adipose tissue in women with PCOS before and after exercise. Design and Methods We conducted a cross-sectional study in 8 women with PCOS and 8 women matched for BMI and age with normal cycles. Women with PCOS also completed a 16-week prospective aerobic exercise-training study. Abdominal subcutaneous adipose tissue biopsies were collected, and primary adipose-derived stromal/stem cell cultures were established from women with PCOS before 16 weeks of aerobic exercise training (n=5) and controls (n=5). Gene expression was measured using real time PCR, in vitro lipolysis was measured using radiolabeled oleate, and PLIN3 protein content was measured by western blotting. Results The expression of PLIN1, PLIN3, and PLIN5, along with coatomers ARF1, ARFRP1, and βCOP were ~80% lower in women with PCOS (all p<0.05). Following exercise training, PLIN3 was the only perilipin to increase significantly (p<0.05), along with coatomers ARF1, ARFRP1, βCOP, and Sec23a (all p<0.05). Furthermore, PLIN3 protein expression was undetectable in the cell cultures from women with PCOS vs. controls. Following exercise training, in vitro adipose oleate oxidation, glycerol secretion, and PLIN3 protein expression were increased, along with reductions in triglyceride content and absence of large lipid droplet morphology. Conclusions These findings suggest that PLIN3 and coatomer GTPases are important regulators of lipolysis and triglyceride storage in the adipose tissue of women with PCOS.

show abstract

Heart rate recovery improves after weight loss in overweight and obese women with polycystic ovary syndrome

Abstract: Weight loss in overweight and obese women with PCOS is associated with improvements in HRR, which suggests improved autonomic function. This highlights the importance of weight loss to reduce the cardiovascular disease risk in these women.

Cited by 20 publications

References 55 publications

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

The Association of Epicardial Fat Thickness with Blunted Heart Rate Recovery in Patients with Metabolic Syndrome

Potential effects of aerobic exercise on the expression of perilipin 3 in the adipose tissue of women with polycystic ovary syndrome: a pilot study

Contact Info

Product

Resources

About