Heart Rate Response to Exercise and Recovery

Tabachnikov, Vsevolod; Saliba, Walid; Aker, Amir; Zafrir, Barak

doi:10.1097/hcr.0000000000000679

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…In addition, exercise-induced accumulation of muscle metabolites and uncontrolled thermoregulation can mediate cardiac sympathetic nerve activity disturbances, ultimately leading to HRR abnormalities (13, 21). However, a recent study found that the predictive value of HRR2 was independent of METs (9), which is consistent with our findings. Therefore, it is more reasonable to explore the optimal time point for HRR to predict endpoint events, considering the study protocol, population, and other conditions.…”

Section: Discussionsupporting

confidence: 93%

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The incremental significance of heart rate recovery as a predictor during exercise-stress myocardial perfusion SPECT imaging in individuals with suspected coronary artery disease

Yang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundMajor adverse cardiac events (MACE) are more likely to occur when abnormal heart rate recovery (HRR). This study aimed to assess the incremental predictive significance of HRR over exercise stress myocardial perfusion single-photon emission computed tomography (MPS) results for MACE in individuals with suspected coronary artery disease (CAD).MethodsBetween January 2014 and December 2017, we continually gathered data on 595 patients with suspected CAD who received cycling exercise stress MPS. HRR at 1, 2, 3, and 4 min were used as study variables to obtain the optimal cut-off values of HRR for MACE. The difference between the peak heart rate achieved during exercise and the heart rate at 1, 2, 3, and 4 min was used to calculate the HRR, as shown in HRR3. Heart rate variations between two locations in time, such as HRR2 min−1 min, were used to establish the slope of HRR. All patients were followed for a minimum of 4 years, with MACE as the follow-up goal. The associations between HRR and MACE were assessed using Cox proportional hazards analyses.ResultsPatients with MACE were older (P = 0.001), and they also had higher rates of hypertension, dyslipidemia, diabetes, abnormal MPS findings (SSS ≥ 5%), medication history (all P < 0.001), and lower HRR values (all P < 0.01). Patients with and without MACE did not significantly vary in their HRR4 min−3 min. The optimal cut-off of HRR1, 2, and 3 combined with SSS can stratify the risk of MACE in people with suspected CAD (all P < 0.001). HRR 1, 2, and 3 and its slope were linked to MACE in multivariate analysis, where HRR3 was the most significant risk predictor. With a global X2 increase from 101 to 126 (P < 0.0001), HRR3 demonstrated the greatest improvement in the model's predictive capacity, incorporating clinical data and MPS outcomes.ConclusionsHRR at 3 min has a more excellent incremental prognostic value for predicting MACE in patients with suspected CAD following cycling exercise stress MPS. Therefore, incorporating HRR at 3 min into known predictive models may further improve the risk stratification of the patients.

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Section: Discussionsupporting

confidence: 93%

“…Heart rate recovery (HRR) represents the balance between parasympathetic reactivation and sympathetic regression based on exercise stress testing (ET) (4,5). The correlation between aberrant HRR and the incidence of MACE in individuals with suspected CAD has been supported by several research (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

The incremental significance of heart rate recovery as a predictor during exercise-stress myocardial perfusion SPECT imaging in individuals with suspected coronary artery disease

Yang

et al. 2023

Front. Cardiovasc. Med.

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“…It is common to observe changes in the central nervous system, such as chronotropic incompetence (CI) and a slower heart rate recovery after exercise [3,4]. Since the autonomic nervous system plays a crucial role in heart rate (HR) recovery after exercise, a delay in this response may indicate autonomic dysfunction, which can be a predictor of disease development and progression [5]. CI has multifactorial origins, but adopting an active lifestyle has been suggested as a safe and effective approach to prevent or reduce changes in insulin and cardiac autonomic neuropathy in individuals with T2DM [6-8], resulting in signi cant improvements in quality of life.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sodium Bicarbonate Supplementation on Physical Performance and Cardiovascular Variables in Middle-aged and Elderly Adults With Type 2 Diabetes Mellitus

Antunes,

Rios,

Sochodolak

et al. 2024

Preprint

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The global epidemic of diabetes mellitus (DM) presents a significant health challenge. Physical exercise is crucial in preventing and treating type 2 DM (T2DM). Supplementation with sodium bicarbonate (SB) may enhance physical performance in T2DM individuals during high-intensity protocols. This study aimed to analyze physical performance, blood glucose, and cardiovascular parameters following acute SB supplementation in middle-aged and elderly adults with T2DM. Thirteen individuals (mean age: 62.15 ± 6.90 years, BMI: 29.14 ± 4.49 kg/m2) with an average disease duration of 5.03 ± 6.64 years participated. They underwent a maximal incremental test (MIT) with either SB or a placebo, administered 60 minutes before the test. Blood pressure (BP), heart rate (HR), and capillary blood glucose were monitored pre- and post-test. Results showed significant differences in MIT duration between the SB and placebo conditions (SB: 481 ± 116.97 seconds, placebo: 439 ± 99.92 seconds, p = 0.005), and in blood glucose levels (p = 0.0001). No significant differences were found in BP, HR, or other cardiovascular variables (p > 0.05). SB supplementation was associated with increased test duration and reduced blood glucose levels, indicating improved physical performance and fatigue reduction. These findings suggest that SB supplementation may be a safe and effective strategy for enhancing physical performance in individuals with T2DM.

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Correlation between Heart rate recovery and Left Atrial phasic functions evaluated by 2D speckle-tracking Echocardiography after Acute Myocardial infarction

Mashayekhi

Mohseni-Badalabadi

Hosseinsabet

et al. 2023

BMC Cardiovasc Disord

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Background Heart rate recovery (HRR) in the exercise test is the index of cardiac autonomic system function and sympathovagal balance impaired in patients with myocardial infarction (MI). An instance is left atrial (LA) phasic function, which is impaired in such patients. In this study, we investigated the role of HRR in predicting LA phasic functions in patients with MI. Methods The present study recruited 144 consecutive patients with ST-elevation MI. A symptom-limited exercise test was performed about 5 weeks after MI, with echocardiography conducted just before the exercise test. The patients were divided into abnormal and normal HRR at 60 s (HRR60) and again into abnormal and normal HRR at 120 s (HRR120) after the exercise test. LA phasic functions, evaluated by 2D speckle-tracking echocardiography, were compared between the 2 groups. Results Patients with abnormal HRR120 had lower LA strain values and strain rates during the reservoir, conduit, and contraction phases, while those with abnormal HRR60 had lower LA strain values and strain rates during the reservoir and conduit phases. The differences were lost after adjustments for possible confounders, except for LA strain and strain rate during the conduit phase, in patients with abnormal HRR120. Conclusions Abnormal HRR120 in the exercise test can independently predict decreased LA conduit function in patients with ST-elevation MI.

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Heart Rate Response to Exercise and Recovery

Cited by 3 publications

References 40 publications

The incremental significance of heart rate recovery as a predictor during exercise-stress myocardial perfusion SPECT imaging in individuals with suspected coronary artery disease

The incremental significance of heart rate recovery as a predictor during exercise-stress myocardial perfusion SPECT imaging in individuals with suspected coronary artery disease

Effects of Sodium Bicarbonate Supplementation on Physical Performance and Cardiovascular Variables in Middle-aged and Elderly Adults With Type 2 Diabetes Mellitus

Correlation between Heart rate recovery and Left Atrial phasic functions evaluated by 2D speckle-tracking Echocardiography after Acute Myocardial infarction

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