Heart rate turbulence after ventricular premature beats in healthy Doberman pinschers and those with dilated cardiomyopathy

Harris, Joanne; Little, Colin; Dennis, John; Patteson, Mark

doi:10.1016/j.jvc.2017.08.005

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…As recording duration all studies regarding dogs used 24 h (Harris et al 2017, Noszczyk 2012a, Noszczyk-Nowak 2012b and the studies regarding mice 24 h (Mersmann et al 2010), 8 h (Stöckigt et al 2015, Stöckigt et al 2014 or 6 h (Petric et al 2012). Three articles with mice (Stöckigt et al 2014, Stöckigt et al 2015, Petric et al 2012 and the article with swines (Wang et al 2011) used induced VPCs.…”

Section: Hrt In Animalsmentioning

confidence: 99%

“…Petric et al calculated TO as the difference of the two intervals before and any two consecutive intervals after the VPC up to the sixth and seventh interval after the VPCIs (Petric et al 2012). As in some studies focusing on humans, two of three studies regarding dogs calculated individual TS values before averaging (Harris et al 2017, Noszczyk-Nowak 2012b, while the third article does not describe the exact methodology (Noszczyk 2012a). Harris et al used the HRT View program and adapted it to dogs, but without further explanation on the nature of the adaption (Harris et al 2017).…”

Section: Hrt In Animalsmentioning

confidence: 99%

“…As in some studies focusing on humans, two of three studies regarding dogs calculated individual TS values before averaging (Harris et al 2017, Noszczyk-Nowak 2012b, while the third article does not describe the exact methodology (Noszczyk 2012a). Harris et al used the HRT View program and adapted it to dogs, but without further explanation on the nature of the adaption (Harris et al 2017).…”

Section: Hrt In Animalsmentioning

confidence: 99%

“…The usage of HRT in animals is similar to HRT in humans. HRT was used as a cardiac marker for the description of implantable cardioverter defibrillator therapy (Wang et al 2011), for comparison between healthy dogs and dogs with DCM (Harris et al 2017, Noszczyk-Nowak 2012b or subaortic stenosis (Noszczyk 2012a). Furthermore, it was used for comparison between healthy mice and mice with heart disease, precisely transverse aortic constriction or myocardial cryoinfarction (Stöckigt et al 2015), and for comparison of wildtypes and mutants (Mersmann et al 2010, Petric et al 2012.…”

Section: Hrt In Animalsmentioning

confidence: 99%

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HRT assessment reviewed: a systematic review of heart rate turbulence methodology

et al. 2020

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Heart rate turbulence (HRT) is a biphasic reaction to a ventricular premature contraction (VPC) mainly mediated by the baroreflex. It can be used for risk stratification in different disease patterns. Despite existing standards there is a lot of variation in terms of measuring and calculating HRT, which complicates research and application. Objective: This systematic review outlines and evaluates the methodological spectrum of HRT research, especially filtering criteria, parameter calculation and thresholds. Approach: The analysis includes all research papers written in English that have been published before 12.10.2018, are listed on PubMed and involve calculation of HRT parameter values. Main results: HRT assessment is still being performed in various ways and important specifications of the methodology are not given in many articles. Nevertheless, some suggestions regarding HRT methodology can be made: a normalised turbulence slope should be used to uncouple the parameter from heart rate and frequency of extrasystoles. Filtering criteria as formerly reviewed in the guidelines should be met and mentioned. The minimal number of VPC snippets (VPCSs) as well as new cut-off values for different risks need to be further evaluated. Most importantly, the exact and complete methodology must be described to ensure reproducibility and comparability. Significance: Methodical variation hinders comparability of research and medical application. Our continuing questions help to further standardise the measurement and calculation of HRT and increase its value for medical risk stratification.

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Section: Hrt In Animalsmentioning

confidence: 99%

Section: Hrt In Animalsmentioning

confidence: 99%

Section: Hrt In Animalsmentioning

confidence: 99%

Section: Hrt In Animalsmentioning

confidence: 99%

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HRT assessment reviewed: a systematic review of heart rate turbulence methodology

et al. 2020

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“…These include the Frank–Starling mechanism, adrenal glands, sympathetic nervous system, renin-angiotensin-aldosterone system, antidiuretic hormone production, and the reticuloendothelial system [8,30]. An increase in the expression of aldosterone receptors in the myocardium of dogs plays an important role in the progression of dilated cardiomyopathy [31-33]. In dogs with dilated cardiomyopathy, increases in the activities of renin and aldosterone, atrial natriuretic peptide, vasopressin, cortisol, catecholamines, nitrates, and nitrites, which are the end products of nitric oxide, are seen.…”

Section: Discussionmentioning

confidence: 99%

Immune-inflammatory concept of the pathogenesis of chronic heart failure in dogs with dilated cardiomyopathy

et al. 2019

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Background: Dilated cardiomyopathy is common in dogs. This form of cardiomyopathy is the main cause of death due to heart disease in dogs. Death can occur suddenly in clinically normal animals as a result of the progression of congestive heart failure (CHF). The pathogenesis of heart failure syndrome in dogs with dilated cardiomyopathy involves activation of the neurohumoral system and immune-mediated inflammation, which leads to further progression of the condition. Heart failure syndrome in dogs with dilated cardiomyopathy is caused by the progressive loss of cardiomyocytes, apoptosis, remodeling of the left ventricle, systolic and diastolic dysfunction, arrhythmias, reduced cerebral blood flow, the involvement of other key internal organs, and intestinal dysbiosis. Aim: This study aimed to determine the immunological and inflammatory mechanisms surrounding the development of heart failure syndrome in dogs with dilated cardiomyopathy. Materials and Methods: The subjects of this study were dogs with a dilated form of cardiomyopathy (n=159), complicated by various functional classes of heart failure syndrome. Evaluation of myocardial remodeling, systolic function, and systemic hemodynamics was performed using EMP-860 Vet and PU-2200V ultrasound scanners according to the standard technique. Electrocardiography was performed with all dogs in right lateral recumbency using the EK1T-04 Midas electrocardiograph (50 mm/s speed and 1 mV gain = 1 cm). Results: In some affected animals, especially in cases of compensated dilated cardiomyopathy, leukocytosis was noted. In patients with dilated cardiomyopathy complicated by heart failure syndrome of various functional classes, the number of neutrophils was significantly increased, and the number of lymphocytes was decreased by 1.9-2.1 times when compared with those in clinically normal animals. In dogs with dilated cardiomyopathy, neutrophilic leukocytosis develops with a simple regenerative shift to the left. The results of immunological studies indicate that dogs with dilated cardiomyopathy develop T lymphocytopenia as compared with clinically normal animals. Conclusion: The central component of heart failure syndrome in dogs with dilated cardiomyopathy is the activation of the neurohumoral system and immune-mediated inflammation. The development of CHF in dogs with dilated cardiomyopathy is caused by the progressive loss of cardiomyocytes, apoptosis, remodeling of the left ventricle, systolic and diastolic dysfunction, arrhythmias, reduced cerebral blood flow, involvement of other key internal organs, and intestinal dysbiosis.

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Inherited cardiomyopathies in veterinary medicine

Stern

Ueda

2018

Pflugers Arch - Eur J Physiol

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Heart rate turbulence after ventricular premature beats in healthy Doberman pinschers and those with dilated cardiomyopathy

Cited by 7 publications

References 41 publications

HRT assessment reviewed: a systematic review of heart rate turbulence methodology

HRT assessment reviewed: a systematic review of heart rate turbulence methodology

Immune-inflammatory concept of the pathogenesis of chronic heart failure in dogs with dilated cardiomyopathy

Inherited cardiomyopathies in veterinary medicine

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