Heart Rate Variability as a Biomarker of Neurocardiogenic Injury After Subarachnoid Hemorrhage

Megjhani, Murad; Kaffashi, Farhad; Terilli, Kalijah; Alkhachroum, Ayham; Esmaeili, Behnaz; Doyle, Kevin; Murthy, Santosh B.; Velázquez, Ángela; Connolly, E. Sander; Roh, David; Agarwal, Sachin; Loparo, Ken A.; Claassen, Jan; Boehme, Amelia K; Park, Soo‐Jin

doi:10.1007/s12028-019-00734-3

Cited by 29 publications

(22 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have explored the association of these findings with complications and outcome 3 , 5 , 6 . RWMAs, elevated NT-proBNP levels as well as some ECG changes, for example ST-segment depression, were significantly associated with an increased risk of death 7 .…”

Section: Introductionmentioning

confidence: 99%

Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage

Anetsberger

Jungwirth

Blobner

et al. 2021

Sci Rep

View full text Add to dashboard Cite

TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1–3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage

Anetsberger

Jungwirth

Blobner

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“… Megjhani et al (2020) analyzed 5-min ECG recordings of 326 patients with SAH. Fifty-six patients developed neurocardiogenic injury within the first 3 days after stroke.…”

Section: Resultsmentioning

confidence: 99%

Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review

et al. 2023

View full text Add to dashboard Cite

Background: Heart rate variability (HRV) is a non-invasive marker of autonomic nervous system function that is based on the analysis of length differences between subsequent RR intervals of the electrocardiogram. The aim of this systematic review was to assess the current knowledge gap in the utility of HRV parameters and their value as predictors of the acute stroke course.Methods: A systematic review was performed in accordance with the PRISMA guidelines. Relevant articles published between 1 January 2016 and 1 November 2022 available in the PubMed, Web of Science, Scopus, and Cochrane Library databases were obtained using a systematic search strategy. The following keywords were used to screen the publications: “heart rate variability” AND/OR “HRV” AND “stroke.” The eligibility criteria that clearly identified and described outcomes and outlined restrictions on HRV measurement were pre-established by the authors. Articles assessing the relationship between HRV measured in the acute phase of stroke and at least one stroke outcome were considered. The observation period did not exceed 12 months. Studies that included patients with medical conditions influencing HRV with no established stroke etiology and non-human subjects were excluded from the analysis. To minimize the risk of bias, disagreements throughout the search and analysis were resolved by two independent supervisors.Results: Of the 1,305 records obtained from the systematic search based on keywords, 36 were included in the final review. These publications provided insight into the usability of linear and non-linear HRV analysis in predicting the course, complications, and mortality of stroke. Furthermore, some modern techniques, such as HRV biofeedback, for the improvement of cognition performance after a stroke are discussed.Discussion: The present study showed that HRV could be considered a promising biomarker of a stroke outcome and its complications. However, further research is needed to establish a methodology for appropriate quantification and interpretation of HRV-derived parameters.

show abstract

“…Hospitalized patients with COVID-19 who experienced SCD had lower parasympathetic activity (RMSSD) and smaller sized adrenal glands. Lower RMSSD has been associated with sudden unexplained death in epilepsy (SUDEP) [ 6 ], SCD in congenital cardiac disease [ 7 ], neurocardiogenic injury in patients with subarachnoid hemorrhage [ 8 ], and stress cardiomyopathy [ 4 ]. Additionally, COVID-19 patients admitted to the ICU have been shown to have lower RMSSD compared to sepsis patients without COVID-19 admitted to the ICU [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Heart rate variability and adrenal size provide clues to sudden cardiac death in hospitalized COVID-19 patients

Ranard

Megjhani²,

Terilli³

et al. 2022

Journal of Critical Care

Self Cite

View full text Add to dashboard Cite

Heart Rate Variability as a Biomarker of Neurocardiogenic Injury After Subarachnoid Hemorrhage

Cited by 29 publications

References 69 publications

Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage

Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage

Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review

Heart rate variability and adrenal size provide clues to sudden cardiac death in hospitalized COVID-19 patients

Contact Info

Product

Resources

About