Heart rate variability associates with asymptomatic coronary atherosclerosis

Simula, Sakari; Vanninen, Esko; Lehto, Seppo; Hedman, Antti; Pajunen, Pia; Syvänne, Mikko; Hartikainen, Juha

doi:10.1007/s10286-013-0220-z

Cited by 20 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Intriguingly, the association between SUA and cf-PWV was stronger among adults with higher HR (≥ 65 bpm). Several cohort studies have found that a synergistic role of high baseline HR and changes in HR during the follow-up period in accelerating increases of PWV [12][13][14]. The results of our study were in accordance with those of several investigations that have shown increased HR at rest was a significant risk factor for CVD and a marker of new onset of atherosclerosis [15].…”

supporting

confidence: 92%

Serum Uric Acid, Hemoglobin A1c, Glucose Metabolism Abnormalities and Early Stage Atherosclerosis in Chinese Adults-The Cardiometabolic Risk in Chinese (CRC) Study

Qiu¹,

Liang²

2016

J Hypertens (Los Angel)

View full text Add to dashboard Cite

Atherosclerotic cardiovascular disease has been one of the leading causes of death in modern society. Pulse wave velocity (PWV) is a gold standard for assessing arterial stiffness and widely used indicator for early atherosclerosis [1,2]. PWVs may reflect the atherosclerotic alterations at central (cf-PWV) or peripheral arteries (cd-PWV and cr-PWV). Several previous studies have shown that hyperuricemia and long-term glycemic exposure were associated with cardiovascular disease [3][4][5] and the adverse effects of serum uric acid (SUA) may occur at early stage of atherosclerosis [6][7][8]. The effects of various glucose exposures are not perfectly concordant and may be independent. However, the available data are very limited on the relationship between SUA, hemoglobin A1c, glucose metabolism abnormalities and pulse wave velocity, an index of early arterial stiffness.In the Cardiometabolic Risk in Chinese (CRC) Study, we performed a community-based health examination survey for subjects (29-79 y) who were randomly selected from residents living in the urban area of Xuzhou, China, in 2009. All subjects were successfully measured for PWVs, blood pressure, body mass index (BMI), heart rate (HR), SUA and other metabolic markers. PWV was based on the distance/time ratio (meters/second), was calculated as the path length divided by the transit time and expressed as m/s. In a cross-sectional study, it was found that SUA was independently associated with brachial ankle PWV (baPWV) in She Ethnic Minority Group of Fujian province in China [9]. However, baPWV is an index of both central and peripheral arterial stiffness index [10]. It is not clear whether SUA levels specifically affect central or peripheral arterial stiffness. In our study of a large sample of Chinese adults, we found that SUA levels were significantly related to central arterial stiffness independent of conventional risk factors, such as sex, BMI, lipids, glucose metabolism [11]. Whereas SUA levels were not associated with peripheral arterial stiffness, measured by cr-PWV and cd-PWV. Intriguingly, the association between SUA and cf-PWV was stronger among adults with higher HR (≥ 65 bpm). Several cohort studies have found that a synergistic role of high baseline HR and changes in HR during the follow-up period in accelerating increases of PWV [12][13][14]. The results of our study were in accordance with those of several investigations that have shown increased HR at rest was a significant risk factor for CVD and a marker of new onset of atherosclerosis [15]. Nevertheless, a recent study in Germany found that decreased heart rate variability correlates to increased cardiovascular risk [16]. In addition, we found significant interaction between hypertension status and SUA level in relation to cf-PWV. In a previous prospective study, it was found that that inflammatory and adiponectin-mediated proatherogenic activation are interrelated, which interact leading to a significant increase of arterial stiffness in essential hypertensive patients [17]. However, th...

show abstract

supporting

confidence: 92%

Serum Uric Acid, Hemoglobin A1c, Glucose Metabolism Abnormalities and Early Stage Atherosclerosis in Chinese Adults-The Cardiometabolic Risk in Chinese (CRC) Study

Qiu¹,

Liang²

2016

J Hypertens (Los Angel)

View full text Add to dashboard Cite

show abstract

“…Nearly all previous reports in this field compared patients with either CAD or cardiac syndrome X to healthy control subjects [12–14, 39, 40]. To our knowledge, the present study is probably the first report that explores the possible CAM differences between patients with CSX and CAD.…”

Section: Discussionmentioning

confidence: 68%

“…Likewise, same psychological stresses may provoke cardiac pain in patients with CSX [3, 11]. In both conditions, namely CSX and CAD, anxiety can reset cardiac autonomic modulations (CAM) towards predominance of sympathetic over the vagal tone, putting victims at higher risk of arrhythmia and sudden death [12–14]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anxiety Level and Cardiac Autonomic Modulations in Coronary Artery Disease and Cardiac Syndrome X Patients

Lutfi

2017

PLoS ONE

View full text Add to dashboard Cite

BackgroundAnxiety and cardiac autonomic modulations (CAM) were thoroughly investigated in coronary artery disease (CAD) and cardiac syndrome X (CSX) patients worldwide, but not among Sudanese with similar pathology.AimsTo compare levels of anxiety and CAM between Sudanese patients with CSX and CAD.Materials and MethodsAnxiety was evaluated in 51 CAD and 26 CSX patients using Taylor Manifest anxiety score (TMAS) questionnaire while heart rate variability derived indices were used to assess CAM, namely natural logarithm of low frequency (LnLF), high frequency (LnHF) and LF/HF ratio (LnLF/HF).ResultsLow anxiety levels were achieved by 6 (23.1%) and 9 (17.6%) patients with CSX and CAD respectively. High anxiety level was achieved by only one (3.8%) patient, who was suffering from CSX. TMAS was significantly higher in CSX (31.27 (21.97)) compared to CAD (21.86 (12.97), P = 0.021). However, abnormally increased anxiety was not associated with higher risk of CSX. LnLF, LnHF and LnLF/HF were comparable in CAD and CSX patients.ConclusionCSX and CAD patients showed comparable CAM. Although anxiety levels were higher in CSX compared to CAD, TMAS ≥ 35 failed to show significant association with CSX.

show abstract

“…Using HRV as a measure of VN activity, a number of studies have shown a relationship between poor VN activity and inflammatory conditions such as rheumatoid arthritis [22], atherosclerosis [23] and Crohn's disease [24]. In a study involving 1882 subjects with ages ranging 21-76 years, a decreased HRV was identified as a significant predictor for the development of diabetes, cardiovascular disease and early mortality [25].…”

Section: Decreased Parasympathetic Tone In Other Medical Conditionsmentioning

confidence: 99%

Can natural ways to stimulate the vagus nerve improve seizure control?

Yuen

Sander

2017

Epilepsy & Behavior

View full text Add to dashboard Cite

The vagus nerve (VN) is the longest cranial nerve innervating the neck, thorax and abdomen, with afferent fibres transmitting a range of interoceptive stimuli and efferent fibres to somatic structures and autonomic preganglions. Over the last few decades, electrical stimulation of the VN using implanted devices (VNS) has been developed leading to its approval for the treatment of epilepsy and depression. More recently non-invasive devices to stimulation the VN have been developed. The VN has many functions and the activity that is most amenable to assessment is its effect in controlling the cardiac rhythm. This can be easily assessed by measuring heart rate variability (HRV). Decreased HRV is a result of poorer vagal parasympathetic tone and is associated with a wide range of ill health conditions including a higher risk of early mortality. People with epilepsy, particularly those with poorly controlled seizures have been shown to have impaired parasympathetic tone. So, might natural ways to stimulate the VN, shown to improve parasympathetic tone as indicated by increased HRV, improve seizure control? There are numerous natural ways that have been shown to stimulate the VN, improving HRV and hence parasympathetic tone. These natural ways fall mainly into 3 categories -stress reduction, exercise and nutrition. Though the natural ways to stimulate the VN have been shown to increase HRV, they have not been shown to reduce seizures. The exception is listening to Mozart's music which has been shown to increase parasympathetic tone and decrease seizures. Clearly much more work is required to examine the effect of the various ways to increase HRV on seizure occurrence.

show abstract

Heart rate variability associates with asymptomatic coronary atherosclerosis

Abstract: The severity and extent of coronary atherosclerosis were related to a shift of cardiac autonomic regulation towards sympathetic predominance in asymptomatic subjects without evidence of myocardial ischemia.

Cited by 20 publications

References 25 publications

Serum Uric Acid, Hemoglobin A1c, Glucose Metabolism Abnormalities and Early Stage Atherosclerosis in Chinese Adults-The Cardiometabolic Risk in Chinese (CRC) Study

Serum Uric Acid, Hemoglobin A1c, Glucose Metabolism Abnormalities and Early Stage Atherosclerosis in Chinese Adults-The Cardiometabolic Risk in Chinese (CRC) Study

Anxiety Level and Cardiac Autonomic Modulations in Coronary Artery Disease and Cardiac Syndrome X Patients

Can natural ways to stimulate the vagus nerve improve seizure control?

Contact Info

Product

Resources

About