Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia

Kang, Jin Ho; Kim, JongKyu; Hong, Seok Hyun; Lee, Young Moo; Choi, Byung Yong

doi:10.5535/arm.2016.40.2.301

Cited by 55 publications

(49 citation statements)

References 35 publications

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“…The COMPASS 31 has already been reported as a useful tool for the evaluation of autonomic dysfunction in various neurologic diseases such as multiple sclerosis, polyneuropathy, and fibromyalgia [10–12]. However, only one previous study has used the COMPASS 31 in MSA and PD patients [7].…”

Section: Introductionmentioning

confidence: 99%

The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism

et al. 2017

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Differentiation of multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD) is important, but an effective tool for differentiation has not been identified. We investigated the efficacy of the composite autonomic symptom scale 31 (COMPASS 31) questionnaire as a tool for evaluating autonomic function in parkinsonism patients. In this study, we enrolled drug-naïve patients with MSA-P and PD, and administered the COMPASS-31 and an objective autonomic dysfunction test (AFT). Demographic and clinical data, including parkinsonism and autonomic dysfunction, were compared between the two groups. Additionally, we determined the optimal COMPASS 31 cut-off score to differentiate MSA-P from PD for use as a screening tool. In this study, 27 MSA-P patients and 41 PD patients were recruited. The total COMPASS 31 score was well correlated with the objective AFT results. When we compared the COMPASS 31 score between the two groups, MSA-P patients showed higher total scores and sub-scores in the orthostatic intolerance, gastrointestinal, and bladder domains compared with PD patients. Similarly, MSA-P patients had more abnormalities in expiration to inspiration ratio, Valsalva ratio and pressure recovery time than PD patients in objective AFT. With 13.25 as the cut-off score for diagnosis of MSA-P, the total COMPASS-31 score demonstrated high sensitivity (92.6%) and moderate specificity (51.2%) with an area under the curve of 0.765. Based on our results, the COMPASS 31 is an effective tool for evaluation of autonomic function in patients with parkinsonism. The COMPASS-31 could be used as a sensitive and convenient screening tool, especially for the differentiation between MSA-P and PD.

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Section: Introductionmentioning

confidence: 99%

The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism

et al. 2017

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“…2,18,19,24,26 En lo referente a las alteraciones a nivel del SNA, hay evidencia de respuesta simpática anormal ante el estrés con repercusión directa en la frecuencia cardiaca, disminución de la variabilidad cardiaca y pérdida de la variación del balance simpático-vagal circadiano, con hiperactividad simpática nocturna, predisponiendo a un riesgo mayor de muerte súbi-ta. 2,20,23,29 Finalmente, en cuanto a las alteraciones del sistema neuroendocrino, se han documentado cambios en el eje hipotálamo-pituitario-adrenal dados por disminución de cortisol en orina en 24 horas y aumento de la hormona …”

Section: Etiopatogeniaunclassified

“…2,17,27,14 Por otro lado, hay evidencia de disminución de la variabilidad cardiaca con aumento del tono simpático. 2,23,19,29 Finalmente, se ha documentado alteraciones en la marcha con repercusión directa sobre la variabilidad de la misma, velocidad del paso, aumento del consumo energético y alteraciones del balance, relacionados con dolor cróni-co, fatiga y alteraciones cognitivas. 32,33,34,35 …”

Section: Manifestaciones Clínicasunclassified

Visión desde la rehabilitación del paciente con fibromialgia

Árias

Varona

2017

Rev Col Med Fis Reh

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RESUMENLa fibromialgia (FM) es una de las causas más frecuentes de dolor crónico musculoesquelético difuso, no inflamatorio, no oncológico. Por lo general se encuentra asociada a trastornos afectivos como depresión y ansiedad, alteraciones del sueño, deterioro cognitivo y múltiples síntomas somáticos inespecíficos, que afectan la funcionalidad y la participación de los individuos en la esfera biopsicosocial, así como la calidad de vida. Por este motivo, es importante realizar, desde la visión de la rehabilitación, un abordaje integral del paciente con FM desde su diagnóstico, hasta su tratamiento, rehabilitación y seguimiento; brindar estrategias con las cuales se pueda disminuir y controlar al máximo la sintomatología, con el fin de mejorar la calidad de vida, la funcionalidad y la independencia de los pacientes. Palabras clave: fibromialgia, dolor crónico, rehabilitación, calidad de vida. DOI: 10.28957/rcmfr.v27n2a1 ABSTRACT Fibromyalgia (FM) is one of the most frequent causes of diffuse, non-inflammatory, nononcologic chronic musculoskeletal pain. It is usually associated with affective disorders such as depression, anxiety, sleep disturbances, cognitive impairment, and multiple nonspecific somatic symptoms that affect the functionality and participation of individuals in the biopsychosocial sphere, as well as quality of life. For this reason, it is important from the vision of rehabilitation to perform an integral approach of the patient with FM from its diagnosis, to its treatment, rehabilitation and follow-up; Provide strategies to reduce and control symptomatology to the maximum, in order to improve the quality of life, functionality and independence of patients.

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“…Heart rate variability (HRV) is a commonly used method for assessment of autonomic dysfunction [4][5][6]. Manzano et al established that smoking leads to an acute alteration in the autonomic control, associated with sympathetic overactivation and diminished vagal activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young “Healthy” Smokers Measured by Heart Rate Variability

Taralov¹,

Dimov²,

Terziyski³

et al. 2018

Preprint

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Background and objectives: Smoking leads to autonomic dysfunction. However, the clinical methods for diagnosing this dysfunction are not sufficient. Since exogenous hypoxia leads to changes in the autonomic cardiac control, the aim of our study was to compare the activity of the autonomic nervous system via heart rate variability (HRV) in young “healthy” smokers and non-smokers before, during and after a short-term exogenous hypoxic exposure. Methods: Twenty-one healthy non-smoking males aged 28.0±7.4 (mean±SD) and fourteen healthy smoking males aged 28.1±4.3 with 9.2±5.6 pack-years were subjected to one-hour hypoxic exposure (FiО2=12.3±1.5%) via hypoxicator (AltiPro 8850 Summit+, Altitude Tech, Canada) with simultaneous recording of electrocardiography and pulse oximetry. HRV data was derived via specific software (Kubios HRV, Finland) by analyzing the pre-hypoxic, hypoxic and post-hypoxic periods. Results: Standard deviation of the intervals between normal beats (SDNN) was higher in non-smokers in the pre-hypoxic period (62.0±32.1 vs 40.3±16.2, p=0.013) but not in hypoxia (75.7±34.8 vs 57.9±18.3, p=0.167). When comparing intragroup HRV changes of shifting from hypoxic to post-hypoxic (normoxic) conditions we found that there is a significant increase in the root mean square of successive RR interval differences (RMSSD) (65.9±40.2 vs 75.1±45.9, p=0.011) and in the high frequency (lnHF) (6.8±1.4 vs 7.2±1.3, p=0.014) and a decrease in LF/HF (3.0±2.3 vs 1.9±1.5, p<0.001), but these changes were observed only in the group of non-smokers. Conclusions: Smoking likely impairs autonomic regulation in young healthy males and may lead to a decreased HRV even before subjective clinical signs and symptoms. Hypoxic exposure test could be applied in clinical practice for early detection of autonomic dysfunction in smokers, because their parasympathetic reactivation is blunted when shifting from hypoxic to normoxic ambient conditions measured by HRV.

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Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia

Cited by 55 publications

References 35 publications

The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism

The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism

Visión desde la rehabilitación del paciente con fibromialgia

Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young “Healthy” Smokers Measured by Heart Rate Variability

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Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia

Cited by 55 publications

References 35 publications

The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism

The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism

Visión desde la rehabilitación del paciente con fibromialgia

Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young &ldquo;Healthy&rdquo; Smokers Measured by Heart Rate Variability

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Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young “Healthy” Smokers Measured by Heart Rate Variability