Heart structure and function in patients with generalized autoimmune diseases: echocardiography with tissue Doppler study

Abstract

Echocardiography with TDE reveals characteristic pathology in different forms of generalized autoimmune diseases reflecting their different pathogenetic mechanisms. Overproduction of collagen in SSc results in diastolic left ventricular dysfunction, while generalized inflammation in SLE and DPM leads mainly to pathologic changes on valvular leaflets and/or pericardium. Interestingly, right ventricular dysfunction is common in all diseases analyzed, regardless of the presence of pulmonary hypertension. Echocardiography, preferably with TDE, could add valuable information about usually asymptomatic heart pathology in an individual patient with generalized autoimmune disease.

Atrial Electromechanical Delay and Diastolic Dysfunction in Primary Sjögren Syndrome

“…Di erent diseases may act on the cardiovascular system through the activity of mediators of in ammation. [12][13][14] A similar association is also found between in ammation and supraventricular arrhythmias. [15] Although data about how cardiovascular system is a ected in SS is limited, le ventricular systolic and diastolic dysfunction, pericardial e usion, pulmonary hypertension and valvular dysfunction have all been reported in patients with SS.…”

“…Myocardial dysfunction can be a result of myocarditis, myocardial brosis, vasculitis or microvascular dysfunction in these patients, but it can also be secondary to general subclinical or clinical in ammatory status. [14,[23][24][25][26] Liang et al showed that diastolic dysfunction is much more prevelant in patients with RA and they concluded that this may potentially be due to chronic autoimmune in ammation. [27] ey found a signi cant relationship between IL-6 and le ventricular diastolic dysfunction.…”

“…20 Plazak and his collegues showed that le ventricular dysfunction may be more prevalent in a spectrum of di erent autoimmune diseases. [14] Rosato et al found regional diastolic dysfunction by tissue doppler echocardiography in patients with systemic sclerosis (SSc) and Paradisp et al showed disturbed le ventricular lling patterns in SLE patients. [21,22] It is clear that le ventricular dysfunction is relatively frequent in in ammatory autoimmmune diseases.…”

Cardiac Involvement in Adult Polymyositis or Dermatomyositis: A Systematic Review

“…Hypothesis: More attention will be focused on the heart in PM/DM as we would have wished, which contribute to improve the prognosis. Methods: All articles published in English were retrieved by searching MEDLINE via PubMed (1975-2011. After selecting eligible articles according to the predefined inclusion and exclusion criteria, a systemic review was carried out.…”

Structural and Functional Changes Evaluated by Echocardiography in Patients With Systemic Sclerosis and Heart Rate Variability

“…-у 32% больных ССД. Некоторые авторы считают, что ДД при ССД связана с гиперпродукцией коллагена [27]. M. D'Alto и соавт.…”