Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

Huang, Qiuyuan; Ye, Jianxin; Huang, Qingling; Chen, Wan-Nan; Wang, Lin; Lin, Wei; Lin, Jianghai; Lin, Xu

doi:10.1515/cclm.2010.043

Cited by 54 publications

(43 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Circulating sHsp27 levels were significantly higher in patients with HCC than in healthy control subjects. Previous studies have reported elevated sHsp27 levels in patients with breast cancer (Fanelli et al 1998;Banerjee et al 2011), non-small cell lung cancer (Zimmermann et al 2012) and both pancreatic and gastric adenocarcinoma (Melle et al 2007;Huang et al 2010); however, this is the first report of a rise in circulating sHsp27 levels in patients with HCC.…”

Section: Discussionmentioning

confidence: 56%

Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

Gruden

Carucci

Lolli

et al. 2013

Cell Stress and Chaperones

View full text Add to dashboard Cite

Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p<0.001) higher in patients with HCC than in the other groups, particularly in those with hepatitis C virus (HCV)-related disease. In HCC patients, sHsp27 levels were not associated with prognostic risk factors, such as size/ multiplicity of nodules and stage. In logistic regression analysis, performed in patients with liver disease, logsHsp27 was associated with a significant age-adjusted 2.5-fold increased odds ratio of HCC and with a significant 4.4-fold higher odds ratio of HCC in the subgroup with HCVrelated liver disease. In receiver operating characteristic curve analysis, sensitivity and specificity of the best sHsp27 cut-off value (456.5 pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73 %, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC.

show abstract

Section: Discussionmentioning

confidence: 56%

Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

Gruden

Carucci

Lolli

et al. 2013

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

“…The role of miR-145 in the maintenance of high level of Hsp-27 was not through direct gene targeting but stabilization of Hsp-27. Although the role and clinical outcome of Hsp-27 in primary tumors has been well studied and documented [33], its function in metastasis invasion is still unclear. Further investigations to identify the mechanism of Hsp-27 involved in CRC metastasis will further enrich our understanding on the up-regulation of miR-145 in CRC.…”

Section: Discussionmentioning

confidence: 99%

Up-Regulation of MicroRNA-145 Associates with Lymph Node Metastasis in Colorectal Cancer

et al. 2014

View full text Add to dashboard Cite

Metastasis is the main cause of mortality in patients with solid tumours. Identifying the exact molecules associated with CRC metastasis may be crucial to understand the process, which might also be translated to the diagnosis and treatment of CRC. In this study, we investigate the association of microRNA expression patterns with the lymph node metastasis of colorectal cancer. Among these candidate miRNAs, the expression of miRNA-145 was significantly related to lymph node metastasis of CRC. Both in vitro and in vivo study demonstrated that up-regulation of miR-145 could improve the ability of migration and invasion of colorectal cancer cell, while no effect on proliferation was observed. The mechanism of this promotion is associated with the stabilization of Hsp-27, a protein which plays an important role in the promotion of metastasis. These results may be crucial to understanding CRC metastasis and may be translated to the diagnosis and treatment of CRC.

show abstract

“…HSPB1 is another chaperone secreted by cells in a non-classical pathway [94] associated to exosomes [93]. In vivo, serum HSPB1 was observed increased in pancreatic carcinoma [95], hepatocellular carcinoma [96], breast cancer [97] and gastric adenocarcinoma patients [98]. …”

Section: Unconventional Mechanisms Of Hsp Secretionmentioning

confidence: 99%

Unconventional Secretion of Heat Shock Proteins in Cancer

Santos

Martins

Hajj

2017

IJMS

View full text Add to dashboard Cite

Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu. HSPs do not possess secretion signal peptides, and their secretion was subject to widespread skepticism until the demonstration of the role of unconventional secretion forms such as exosomes. Secretion of HSPs may confer immune system modulation and be a cell-to-cell mediated form of increasing stress resistance. Thus, there is a wide potential for secreted HSPs in resistance of cancer therapy and in the development new therapeutic strategies.

show abstract

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

Cited by 54 publications

References 38 publications

Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

Up-Regulation of MicroRNA-145 Associates with Lymph Node Metastasis in Colorectal Cancer

Unconventional Secretion of Heat Shock Proteins in Cancer

Contact Info

Product

Resources

About