Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise

Negishi-Oshino, Reina; Ohgami, Nobutaka; He, Tao; Li, Xiang; Kato, Masashi; Kobayashi, Masayoshi; Gu, Yishuo; Komuro, Kanako; Angelidis, Charalampos

doi:10.1007/s00204-019-02587-3

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…This can lead to the absorption of K + through top channels of the cilia, depolarizing the membrane of HCs. This depolarization can cause calcium influx by opening voltage-dependent calcium channels at the bases of HCs, stimulating the release of neurotransmitters to increase the firing frequency of nerve fibers (Negishi-Oshino et al 2019 ).…”

Section: Structural and Functional Features Of Vestibular Hair Cellsmentioning

confidence: 99%

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Progress in protecting vestibular hair cells

Jiang

Zheng

2021

Arch Toxicol

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Vestibular hair cells are mechanosensory receptors that are capable of detecting changes in head position and thereby allow animals to maintain their posture and coordinate their movement. Vestibular hair cells are susceptible to ototoxic drugs, aging, and genetic factors that can lead to permanent vestibular dysfunction. Vestibular dysfunction mainly results from the injury of hair cells, which are located in the vestibular sensory epithelium. This review summarizes the mechanisms of different factors causing vestibular hair cell damage and therapeutic strategies to protect vestibular hair cells.

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Section: Structural and Functional Features Of Vestibular Hair Cellsmentioning

confidence: 99%

“…In the US, about 18% of the population aged 40–49 years, and 49% of the population aged 60–69 years suffer from vestibular dysfunction. The morbidity of this disorder arrives at 80% among people over 80 years old in the US (Negishi-Oshino et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Progress in protecting vestibular hair cells

Jiang

Zheng

2021

Arch Toxicol

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“…For determination of significant differences among more than three groups for parametric data, one-way ANOVA followed by Tukey's post hoc multiple comparison test was used. For nonparametric data, the Mann-Whitney U test and the Steel-Dwass test with the alpha level set to 0.05 were used as previously reported (44). Values of p < 0.05 were considered to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Cerebellar hypoplasia in mice was assessed by performance on a rotarod analysis with a rotating rod treadmill (Ugo Basile; Stoelting Co) and by a footprint test as previously reported (42)(43)(44). For the rotarod test, the performance of mice at P21 on the rod until a maximum retention time of 120 s per trial was assessed.…”

Section: Behavior Analysesmentioning

confidence: 99%

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Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome

Ohgami

Iizuka

Hirai

et al. 2021

Journal of Biological Chemistry

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The c- RET proto-oncogene encodes a receptor-tyrosine kinase. Loss-of-function mutations of RET have been shown to be associated with Hirschsprung disease and Down's syndrome (HSCR-DS) in humans. DS is known to involve cerebellar hypoplasia, which is characterized by reduced cerebellar size. Despite the fact that c-Ret has been shown to be associated with HSCR-DS in humans and to be expressed in Purkinje cells (PCs) in experimental animals, there is limited information about the role of activity of c-Ret/c-RET kinase in cerebellar hypoplasia. We found that a loss-of-function mutation of c-Ret Y1062 in PCs causes cerebellar hypoplasia in c-Ret mutant mice. Wild-type mice had increased phosphorylation of c-Ret in PCs during postnatal development, while c-Ret mutant mice had postnatal hypoplasia of the cerebellum with immature neurite outgrowth in PCs and granule cells (GCs). c-Ret mutant mice also showed decreased numbers of glial fibers and mitogenic sonic hedgehog (Shh)-positive vesicles in the external germinal layer of PCs. c-Ret-mediated cerebellar hypoplasia was rescued by subcutaneous injection of a smoothened agonist (SAG) as well as by reduced expression of Patched1 , a negative regulator for Shh. Our results suggest that the loss-of-function mutation of c-Ret Y1062 results in the development of cerebellar hypoplasia via impairment of the Shh-mediated development of GCs and glial fibers in mice with HSCR-DS.

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Decreased hearing levels at frequencies for understanding speech in tannery workers exposed to a high level of trivalent chromium in Bangladesh

Ohgami

Hossain

et al. 2022

Chemosphere

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Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise

Cited by 6 publications

References 39 publications

Progress in protecting vestibular hair cells

Progress in protecting vestibular hair cells

Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome

Decreased hearing levels at frequencies for understanding speech in tannery workers exposed to a high level of trivalent chromium in Bangladesh

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