Heat Shock Proteins and Periodontitis – Cross-Reaction Between Bacterial and Human HSP in Periodontal Infection Linking with Cardiovascular Diseases

Yamamoto, Tadashi; Eguchi, Takanori

doi:10.1007/7515_2020_24

Cited by 4 publications

(4 citation statements)

References 54 publications

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“…DnaK has previously been implicated in molecular mimicry of other pathogenic bacteria like Streptococcus pneumoniae [ 16 ] and Salmonella typhi [ 15 ]. DnaK and other molecular chaperones like GroEL have been implicated in multiple autoimmune disorders [ 116 , 146 , 147 , 148 , 149 , 150 , 151 ]. DnaK has been associated with autoimmune atrophic gastritis caused by H. pylori [ 152 ], while Qeshmi et al have reported its presence in multiple sclerosis as well [ 153 ].…”

Section: Discussionmentioning

confidence: 99%

Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach

Alshamrani,

Mashraqi,

Alzamami

et al. 2023

Microorganisms

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Molecular mimicry, a phenomenon in which microbial or environmental antigens resemble host antigens, has been proposed as a potential trigger for autoimmune responses. In this study, we employed a bioinformatics approach to investigate the role of molecular mimicry in Clostridioides difficile-caused infections and the induction of autoimmune disorders due to this phenomenon. Comparing proteomes of host and pathogen, we identified 23 proteins that exhibited significant sequence homology and were linked to autoimmune disorders. The disorders included rheumatoid arthritis, psoriasis, Alzheimer’s disease, etc., while infections included viral and bacterial infections like HIV, HCV, and tuberculosis. The structure of the homologous proteins was superposed, and RMSD was calculated to find the maximum deviation, while accounting for rigid and flexible regions. Two sequence mimics (antigenic, non-allergenic, and immunogenic) of ≥10 amino acids from these proteins were used to design a vaccine construct to explore the possibility of eliciting an immune response. Docking analysis of the top vaccine construct C2 showed favorable interactions with HLA and TLR-4 receptor, indicating potential efficacy. The B-cell and T-helper cell activity was also simulated, showing promising results for effective immunization against C. difficile infections. This study highlights the potential of C. difficile to trigger autoimmunity through molecular mimicry and vaccine design based on sequence mimics that trigger a defensive response.

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Section: Discussionmentioning

confidence: 99%

Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach

Alshamrani,

Mashraqi,

Alzamami

et al. 2023

Microorganisms

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“…The cytokine theory is based on the fact of host–parasite interaction due to which cells of the immune system release inflammatory mediators and these mediators have a key role in vascular endothelium wall damage [ 23 ]. Next is the theory of auto immunization that emphasizes the importance of heat shock proteins (HSP65) expressed on the periodontal pathogens such as Porphyromonas gingivalis , Actinobacillus actinomycetemcomitans , and Prevotella intermedia [ 24 ]. Bacterial lipopolysaccharides from the periodontal regions pass into the bloodstream and initiate the genesis of acute-phase proteins such as the C-reaction protein (CRP) in a patient of periodontitis-type chronic infection.…”

Section: Periodontitis and Systemic Complicationsmentioning

confidence: 99%

“…In-vitro studies of nanofibrous films cut into 10 × 10 mm 2 samples showed that the addition of HANPs improved the cell viability by about 50 and AgNPs provided sustained antibacterial activity (40 mm zone of inhibition diameter) for 32 days. Additionally, the nanofibrous scaffolds offer optimum mechanical properties, tensile modulus (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38), and a desirable degradation profile (40-70% of its mass in eight weeks).…”

Section: Current Treatment Modalities and Advanced Pharmaceutical Approachmentioning

confidence: 99%

Periodontitis and Systemic Disorder—An Overview of Relation and Novel Treatment Modalities

et al. 2021

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Periodontitis, a major oral disease, affects a vast majority of the population but has been often ignored without realizing its long-fetched effects on overall human health. A realization in recent years of its association with severe diseases such as carditis, low birth weight babies, and preeclampsia has instigated dedicated research in this area. In the arena of periodontal medicines, the studies of past decades suggest a link between human periodontal afflictions and certain systemic disorders such as cardiovascular diseases, diabetes mellitus, respiratory disorders, preterm birth, autoimmune disorders, and cancer. Although, the disease appears as a locoregional infection, the periodontal pathogens, in addition their metabolic products and systemic mediators, receive access to the bloodstream, thereby contributing to the development of systemic disorders. Mechanism-based insights into the disease pathogenesis and association are highly relevant and shall be useful in avoiding any systemic complications. This review presents an update of the mechanisms and relationships between chronic periodontal infection and systemic disorders. Attention is also given to highlighting the incidence in support of this relationship. In addition, an attempt is made to propose the various periodonto-therapeutic tools to apprise the readers about the availability of appropriate treatment for the disease at the earliest stage without allowing it to progress and cause systemic adverse effects.

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“…They act as chaperones and play roles in protein maturation, aid in conformational folding and assembly of newly synthesized proteins, refolding of denatured proteins and assist in the degradation of irreparable proteins and toxins and protect against their accumulation. Therefore their overexpression before an injury has protective effects (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). HSP90 has three structural domains: 1) an N-terminal nucleotide-binding domain (NBD) that also binds HSP90 inhibitors and may bind peptides, 2) a middle segment that interacts with client proteins; and 3) the C terminus, which is implicated in homodimerization.…”

Section: Introductionmentioning

confidence: 99%

Role Of Heat Shock Proteins in Various Diseases with Special Emphasis on Periodontal Inflammation - A Review.

2022

pnr

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Heat shock proteins (HSPs) behave as molecular chaperones of cell protection, immediately after exposure to external shock/stress. It is responsible for cellular homeostasis and repair. Various forms of HSPs are correlated with inflammation and neoplasia. HSP70 is a key molecule that is shown to increase in gingivitis and periodontitis. It is also expressed in gingival crevicular fluids and could be a potential marker for severity of periodontal disease.

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Heat Shock Proteins and Periodontitis – Cross-Reaction Between Bacterial and Human HSP in Periodontal Infection Linking with Cardiovascular Diseases

Cited by 4 publications

References 54 publications

Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach

Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach

Periodontitis and Systemic Disorder—An Overview of Relation and Novel Treatment Modalities

Role Of Heat Shock Proteins in Various Diseases with Special Emphasis on Periodontal Inflammation - A Review.

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