Heat Shock Proteins in Oxidative and Nitrosative Stress

Kattaia, Asmaa A. A.; El-Baset, Samia A. Abd; Mohamed, Eman M.

doi:10.1007/978-3-319-90725-3_7

Cited by 5 publications

(4 citation statements)

References 66 publications

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“…Heat shock protein 70 (HSP70) is one of the most important proteins in the heat shock protein (HSP) family [8,9]. The level of HSP70 is very low under non-stress condition, and the heat stress transcription factor (HSF) exists in the cytoplasm in the form of monomers.…”

Section: Introductionmentioning

confidence: 99%

Effect of Glutamine on Antioxidant Capacity and Lipid Peroxidation in the Breast Muscle of Heat-stressed Broilers via Antioxidant Genes and HSP70 Pathway

Chen

Dai

et al. 2020

Animals

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This study investigated whether Glutamine (Gln) could be used as an additive to improve antioxidant capacity in the breast muscle of heat-stressed broilers. Two hundred and forty 22-day-old Arbor Acres broilers in the G1, G2, G3, and G4 groups (n = 60 each) were housed in a cyclic hot environment and fed the basal diet with 0%, 0.5%, 1.0%, and 1.5% Gln, respectively. Compared with the G1 group, dietary 1.5% Gln increased (p < 0.05) pH and b* values, but decreased (p < 0.05) L* cooking loss, drip loss, and water loss rate in breast meat of heat-stressed broilers. Malondialdehyde levels in the breast muscle were lower (p < 0.05) in 1.0% and 1.5% Gln groups than that of the heat-stress group. Compared with the G1 group, dietary 1.5% Gln increased (p < 0.05) catalase (CAT), glutathione, glutathione peroxidase (GSH-Px,) and total antioxidant capacity in the breast muscle of heat-stressed broilers. Furthermore, the CAT, GSH-Px, HSP70 mRNA expression levels, and HSP70 protein expression levels were increased (p < 0.05) in the G3 and G4 groups compared with the G1 group. In sum, Gln alleviated antioxidant capacity and lipid peroxidation in the breast muscle of heat-stressed broilers through antioxidant genes and HSP70 pathways.

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Section: Introductionmentioning

confidence: 99%

Effect of Glutamine on Antioxidant Capacity and Lipid Peroxidation in the Breast Muscle of Heat-stressed Broilers via Antioxidant Genes and HSP70 Pathway

Chen

Dai

et al. 2020

Animals

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“…Heat shock proteins are a family of proteins produced following exposure to stressful circumstances e.g. heat, blood loss, hypoxia, injury by ischemia–reperfusion and other surgeries 54 , 57 . HSP70 maintains cellular homeostasis and directs the cellular redox status by regulating glutathione-associated enzymes 58 .…”

Section: Discussionmentioning

confidence: 99%

Mesna ameliorates acute lung injury induced by intestinal ischemia–reperfusion in rats

El-Baset

El-Haleem

Abdul-Maksoud

et al. 2021

Sci Rep

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The lung is severely affected by intestinal ischemia–reperfusion (I–R) injury. Mesna, a thiol compound, possess anti-inflammatory and antioxidant properties. We aimed in the present work to explore the potential beneficial effects of Mesna on the acute lung damage mediated by intestinal I–R in a rat model. Forty male adult albino rats were randomly separated into; control, intestinal I–R, Mesna I and Mesna II groups. Mesna was administered by intraperitoneal injection at a dose of 100 mg/kg, 60 min before ischemia (Mesna I) and after reperfusion (Mesna II). Arterial blood gases and total proteins in bronchoalveolar lavage (BAL) were measured. Lung tissue homogenates were utilized for biochemical assays of proinflammatory cytokines and oxidative stress markers. Lung specimens were managed for examination by light and electron microscopy. Our results revealed that Mesna attenuated the histopathological changes and apoptosis of the lung following intestinal I–R. Mesna also recovered systemic oxygenation. Mesna suppressed neutrophil infiltration (as endorsed by the reduction in MPO level), reduced ICAM-1 mRNA expression, inhibited NF-κB pathway and reduced the proinflammatory cytokines (TNF-α, IL-1β and IL-6) in the lung tissues. Mesna maintained the antioxidant profile as evidenced by the elevation of the tissue GPx and SOD and down-regulation of HSP70 immune-expressions. Accordingly, Mesna treatment can be a promising way to counteract remote injury of the lung resulted from intestinal I–R.

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“…At that time, it was thought that the release of HSP would occur only with an abrupt change in temperature, which was coined heat shock response. Subsequently, HSPs were identified as a typical response to a long list of stresses, such as oxidative stress, nitrosative stress, pH change, fever, and inflammation [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Heat-Shock Proteins in Esophagogastric Cancer

Tustumi

Agareno

Galletti

et al. 2022

Cells

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Heat-shock proteins (HSPs) are a family of proteins that have received considerable attention over the last several years. They have been classified into six prominent families: high-molecular-mass HSP, 90, 70, 60, 40, and small heat shock proteins. HSPs participate in protein folding, stability, and maturation of several proteins during stress, such as in heat, oxidative stress, fever, and inflammation. Due to the immunogenic host’s role in the combat against cancer cells and the role of the inflammation in the cancer control or progression, abnormal expression of these proteins has been associated with many types of cancer, including esophagogastric cancer. This study aims to review all the evidence concerning the role of HSPs in the pathogenesis and prognosis of esophagogastric cancer and their potential role in future treatment options. This narrative review gathers scientific evidence concerning HSPs in relation to esophagus and gastric cancer. All esophagogastric cancer subtypes are included. The role of HSPs in carcinogenesis, prognostication, and therapy for esophagogastric cancer are discussed. The main topics covered are premalignant conditions for gastric cancer atrophic gastritis, Barrett esophagus, and some viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV). HSPs represent new perspectives on the development, prognostication, and treatment of esophagogastric cancer.

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Heat Shock Proteins in Oxidative and Nitrosative Stress

Cited by 5 publications

References 66 publications

Effect of Glutamine on Antioxidant Capacity and Lipid Peroxidation in the Breast Muscle of Heat-stressed Broilers via Antioxidant Genes and HSP70 Pathway

Effect of Glutamine on Antioxidant Capacity and Lipid Peroxidation in the Breast Muscle of Heat-stressed Broilers via Antioxidant Genes and HSP70 Pathway

Mesna ameliorates acute lung injury induced by intestinal ischemia–reperfusion in rats

The Role of the Heat-Shock Proteins in Esophagogastric Cancer

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