Heat shock proteins in pathology: A review

Jindal, Deepti Garg; Jindal, Varun; Joshi, Sumit; Bhojia, Ishita; Chawdhry, Arjun

doi:10.1016/j.jpfa.2016.11.002

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The blocking of apoptosis is accomplished by high-molecular-weight HSPs (including HSP70) binding to caspases, which interferes with the activation of the latter. The neoplastic tissue accumulates a pool of cells with latent mutations, which promotes further tumour development [ 19 ].…”

Section: The Role Of Hsp70 In Apoptosismentioning

confidence: 99%

The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer

Boliukh¹,

Rombel‐Bryzek²,

Żuk³

et al. 2021

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Heat shock proteins (HSPs) are chaperones with highly conservative primary structure, necessary in the processes of protein folding to the most energetically advantageous conformation and maintaining their stability. HSPs perform a number of important functions in various cellular processes and are capable of modulating pathophysiological conditions at the cellular and systemic levels. An example is the high level of HSP expression in neoplastic tissues, which disrupts the apoptosis of transformed cells and promotes the processes of proliferation, invasion, and metastasis. In addition, an increasing amount of information is appearing about the participation of HSPs in the formation of multidrug resistance.This paper provides a review of the current state of research on the fundamental importance as well as the diagnostic and prognostic role of various classes of HSP in cancer treatment. It presents the prospects for using HSPs as biological markers of disease progression and targets in various cancer treatment strategies. However, the need for additional research is quite high. Only numerous joint efforts of research groups will allow the effective use of HSPs as a tool to combat cancer.

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Section: The Role Of Hsp70 In Apoptosismentioning

confidence: 99%

The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer

Boliukh¹,

Rombel‐Bryzek²,

Żuk³

et al. 2021

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“…Blocking of apoptosis is achieved by binding of high-molecular HSPs with caspases and impairment of their activation. This creates conditions in the tumor tissue for the accumulation of a pool of cells with hidden mutations and further tumor progression [75].…”

Section: Peculiarities Of Prostate Cancer Bone Metastasesmentioning

confidence: 99%

Molecular Aspects of the Bone Metastastases Development in Prostate Cancer

Piddubnyi

Moskalenko

2019

EUMJ

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MOLECULAR ASPECTS OF THE BONE METASTASTASES DEVELOPMENT IN PROSTATE CANCER. This review is devoted to the topical issue of modern medicinethe molecular mechanisms and factors for the development of bone metastases of malignant tumors, in particular prostate cancer. The recent publication on the formation and progression of prostate cancer bone metastases were analyzed in this study. The expression of some molecular markers in tumor and metastatic tissue and their role in tumor progression were also analyzed in this study. A common concept for the development of specific metastases is a seed and soil theory. According to this concept, circulating cancer cells recognize some organs as the optimal microenvironment for their development. However, the molecular mechanisms of this phenomenon remain unknown. Molecular and genetic features of the androgen receptors expression in the tumor and their role in metastatic tissue were summarized and compared in this study. We also demonstrated the effect of these receptors on the development of osteoblastic metastases and castration-resistant prostate cancer. Authors analyzed and summarized data about the role of p53 protein, Bax and activated caspase 3 in apoptosis, mechanisms of neoangiogenesis and remodeling of tumor connective tissue with matrix metalloproteinase 1, the presence of collagen type I and osteonectin in neoplastic tissues and the role of inflammation in metastasis development. Functions of heat shock proteins with molecular masses of 70 and 90 kDa and their role in tumor and metastatic tissue were also analyzed. Thus, the study complements and summarizes the data on the development of bone metastases of prostate cancer. The study analyzed the molecular characteristics of prostate cancer during its metastatic spread.

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Heat shock proteins in pathology: A review

Cited by 2 publications

References 21 publications

The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer

The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer

Molecular Aspects of the Bone Metastastases Development in Prostate Cancer

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