Heat shock responsive drug delivery system based on mesoporous silica nanoparticles coated with temperature sensitive gatekeeper

Cho, In Hye; Shim, Man Kyu; Jung, Bom; Jang, Eun Hyang; Park, Min Ju; Kang, Han Chang; Kim, Jong Ho

doi:10.1016/j.micromeso.2017.06.042

Cited by 41 publications

(15 citation statements)

References 23 publications

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“…Instinctively, the system is operated based on a reversible switching-on/off mechanism at the mesopore entry via diverse internal or external decoration or modification over the surface. These composites at elevated environmental temperatures exhibit phase transition, enabling the release of drugs through changes in their hydrophobic interactions [ 284 , 285 ]. More often, the thermogelling polymers, such as pNIPAAm, present an exciting feature of gelation at elevated temperatures, such that they facilitate the localized delivery of drugs in a controlled fashion [ 285 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

et al. 2022

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Despite exceptional morphological and physicochemical attributes, mesoporous silica nanoparticles (MSNs) are often employed as carriers or vectors. Moreover, these conventional MSNs often suffer from various limitations in biomedicine, such as reduced drug encapsulation efficacy, deprived compatibility, and poor degradability, resulting in poor therapeutic outcomes. To address these limitations, several modifications have been corroborated to fabricating hierarchically-engineered MSNs in terms of tuning the pore sizes, modifying the surfaces, and engineering of siliceous networks. Interestingly, the further advancements of engineered MSNs lead to the generation of highly complex and nature-mimicking structures, such as Janus-type, multi-podal, and flower-like architectures, as well as streamlined tadpole-like nanomotors. In this review, we present explicit discussions relevant to these advanced hierarchical architectures in different fields of biomedicine, including drug delivery, bioimaging, tissue engineering, and miscellaneous applications, such as photoluminescence, artificial enzymes, peptide enrichment, DNA detection, and biosensing, among others. Initially, we give a brief overview of diverse, innovative stimuli-responsive (pH, light, ultrasound, and thermos)- and targeted drug delivery strategies, along with discussions on recent advancements in cancer immune therapy and applicability of advanced MSNs in other ailments related to cardiac, vascular, and nervous systems, as well as diabetes. Then, we provide initiatives taken so far in clinical translation of various silica-based materials and their scope towards clinical translation. Finally, we summarize the review with interesting perspectives on lessons learned in exploring the biomedical applications of advanced MSNs and further requirements to be explored. Graphical Abstract

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Section: Biomedical Applicationsmentioning

confidence: 99%

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

et al. 2022

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“…A summary of recent stimuli responsive mesoporous systems having an application in cancer is enumerated in Table 3. [137][138][139][140][141][142][143][144][145][146] pH…”

Section: Stimuli Responsive Msns Targetingmentioning

confidence: 99%

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

Shah¹,

Rajput²

2019

IJPER

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Background: In nanotechnology, the most promising inorganic materials for cancer targeting are Mesoporous silica nanoparticles (MSNs). This review gives a state of the art description of current status and applications of surface functionalized MSNs in the field of cancer theranostics. It also gives a detailed description of surface decorated MSNs researched upon so far in various types of cancer and the benefits associated with these. Applications: Ease of surface functionalization also offers additional functionalities like cell recognition, absorption of specific biomolecules, improving cell interaction and cellular uptake that significantly modifies the in vitro and in vivo behavior of the drug. Therefore, they have proved to be effective in gene delivery and multi drug resistance cancer treatment. Though, their biocompatibility still remains debatable. Biodegradation of MSNs is quite simple and it is safely excreted through kidneys via silanoic acid formation. Moreover, the USFDA has already approved the silica under the 'GRAS' category which has further made MSNs a thrust area for research in cancer theranostics. Summary: This review summarizes the journey of multifunctional MSNs beginning with its origin, mechanism of formation of mesoporous structure with surface functionalization to till date and recent advances in the arena of cancer targeting.

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“…In addition to the widely used PNIPAM, copolymers are also used as gatekeeper for temperature controlled release . A very latest report by Cho et al . functionalized MSNs with temperature‐sensitive PEG/poly(ϵ‐caprolactone) (PEG/PCL) multiblock copolymer (MBC‐MSN) as gatekeepers, allowing the release of entrapped drugs in response to heat shock stimuli.…”

Section: Stimuli‐responsive Drug Delivery From Polymer‐brush‐grafted mentioning

confidence: 99%

Polymer‐Brush‐Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery

et al. 2018

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Mesoporous silica nanoparticles (MSNs) have been demonstrated to be one of the most promising drug-delivery systems (DDSs) to transport a variety of drugs/biomolecules. Functionalization of MSN surfaces with responsive polymer brushes leads to intelligent and controllable drug-delivery properties, that is, the encapsulated drugs/biomolecules will only be released upon certain stimuli including pH, temperature, light, enzyme, ultrasound, or redox, thus maximizing their therapeutic efficiency and minimizing side effects. These polymer brushes can also increase the stability and extend the release period of the loaded cargoes. This Minireview presents an overview of recent research progress on stimuli-responsive controlled DDSs based on polymer-brush-grafted MSNs. Utilizing the switching abilities of the grafted responsive polymer brushes, the smart DDSs show great potential for biomedical applications, especially for cancer therapy.

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Heat shock responsive drug delivery system based on mesoporous silica nanoparticles coated with temperature sensitive gatekeeper

Cited by 41 publications

References 23 publications

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

Polymer‐Brush‐Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery

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