Heat stress lipids and schizophrenia

Bates, Paul Raymond; Hawkins, A.; Mahadik, Sahebarao P.; McGrath, John J.

doi:10.1016/s0952-3278(96)90153-2

Cited by 16 publications

(9 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that HSPs are expressed during development of the central nervous system (CNS) in a temporally and spatially controlled pattern that favors neuronal differentiation and survival (Reed-Herbert et al 2006). Among several subfamilies of HSPs, proteins with molecular masses of 70 kDa (HSP70) seem to play a pivotal role in protection against damage to the CNS under stress conditions at vulnerable stages of embryonic development (Bates et al 1996;Reed-Herbert et al 2006). Expression of HSP70 in the CNS has been observed following a variety of stresses such as elevated temperature, hypoxia, ischemia, oxidative stress, or other pathological conditions that have also been indicated as risk factors for the development of schizophrenia (Bates et al 1996;Kim et al 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Among several subfamilies of HSPs, proteins with molecular masses of 70 kDa (HSP70) seem to play a pivotal role in protection against damage to the CNS under stress conditions at vulnerable stages of embryonic development (Bates et al 1996;Reed-Herbert et al 2006). Expression of HSP70 in the CNS has been observed following a variety of stresses such as elevated temperature, hypoxia, ischemia, oxidative stress, or other pathological conditions that have also been indicated as risk factors for the development of schizophrenia (Bates et al 1996;Kim et al 2001). It has been hypothesized that the defective production or function of HSPs in response to embryonic insults may lead to the neurodevelopmental abnormalities that are observed in schizophrenic individuals (Bates et al 1996).…”

Section: Introductionmentioning

confidence: 99%

“…Expression of HSP70 in the CNS has been observed following a variety of stresses such as elevated temperature, hypoxia, ischemia, oxidative stress, or other pathological conditions that have also been indicated as risk factors for the development of schizophrenia (Bates et al 1996;Kim et al 2001). It has been hypothesized that the defective production or function of HSPs in response to embryonic insults may lead to the neurodevelopmental abnormalities that are observed in schizophrenic individuals (Bates et al 1996). In fact, many experimental studies using both animal models and tissue culture systems have shown the neuroprotective effect of HSP70.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population

Kowalczyk

Owczarek

Suchanek

et al. 2014

Cell Stress and Chaperones

View full text Add to dashboard Cite

HSP70 genes have been considered as promising schizophrenia candidate genes based on their protective role in the central nervous system under stress conditions. In this study, we analyzed the potential implication of HSPA1A +190G/C, HSPA1B +1267A/G, and HSPA1L +2437T/C polymorphisms in the susceptibility to paranoid schizophrenia in a homogenous Caucasian Polish population. In addition, we investigated the association of the polymorphisms with the clinical variables of the disease. Two hundred and three patients with paranoid schizophrenia and 243 healthy controls were enrolled in the study. Polymorphisms of HSPA1A, -1B, and -1L genes were genotyped using the PCR-RFLP technique. Analyses were conducted in entire groups and in subgroups that were stratified according to gender. There were significant differences in the genotype and allele frequencies of HSPA1A polymorphism between the patients and controls. The +190CC genotype and +190C allele were overrepresented in the patients and significantly increased the risk for developing schizophrenia (OR=3.45 and OR=1.61, respectively). Interestingly, such a risk was higher for females with the +190CC genotype than for males with the +190CC genotype (OR=5.78 vs. OR=2.76). We also identified the CGT haplotype as a risk haplotype for schizophrenia and demonstrated the effects of HSPA1A and HSPA1B genotypes on the psychopathology and age of onset. Our study provided the first evidence that the HSPA1A polymorphism may potentially increase the risk of developing paranoid schizophrenia. Further independent analyses in different populations to evaluate the role of gender are needed to replicate these results.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population

Kowalczyk

Owczarek

Suchanek

et al. 2014

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

“…Other potential TLR-4 regulatory molecules modulated by paliperidone, especially in acute stress conditions, are HSP70 and HGMB1. HSP70 is a chaperone involved in neurodevelopment and neuroprotection, and its defective production, caused by stress during neuronal development, could have a role in the pathophysiology of psychotic disease ( Bates et al, 1996 ). Furthermore, an association between HSP70 gene polymorphisms and clinical variations of schizophrenia ( Kim et al, 2008 ; Pae et al, 2009 ) and in first-psychotic-episode, drug-naïve schizophrenic patients ( Bozidis et al, 2014 ) also exists.…”

Section: Discussionmentioning

confidence: 99%

Paliperidone Prevents Brain Toll-Like Receptor 4 Pathway Activation and Neuroinflammation in Rat Models of Acute and Chronic Restraint Stress

MacDowell

Caso

Martín-Hernández

et al. 2015

International Journal of Neuropsychopharmacology

View full text Add to dashboard Cite

Background:Alterations in the innate immune/inflammatory system have been proposed to underlie the pathophysiology of psychotic disease, but the mechanisms implicated remain elusive. The main agents of the innate immunity are the family of toll-like receptors (TLRs), which detect circulating pathogen-associated molecular patterns and endogenous damage-associated molecular patterns (DAMPS). Current antipsychotics are able to modulate pro- and anti-inflammatory pathways, but their actions on TLRs remain unexplored.Methods:This study was conducted to elucidate the effects of paliperidone (1mg/Kg i.p.) on acute (6 hours) and chronic (6 hours/day during 21 consecutive days) restraint stress–induced TLR-4 pathway activation and neuroinflammation, and the possible mechanism(s) related (bacterial translocation and/or DAMPs activation). The expression of the elements of a TLR-4-dependent proinflammatory pathway was analyzed at the mRNA and protein levels in prefrontal cortex samples.Results:Paliperidone pre-treatment prevented TLR-4 activation and neuroinflammation in the prefrontal cortices of stressed rats. Regarding the possible mechanisms implicated, paliperidone regulated stress-induced increased intestinal inflammation and plasma lipopolysaccharide levels. In addition, paliperidone also prevented the activation of the endogenous activators of TLR-4 HSP70 and HGMB-1.Conclusions:Our results showed a regulatory role of paliperidone on brain TLR-4, which could explain the therapeutic benefits of its use for the treatment of psychotic diseases beyond its effects on dopamine and serotonin neurotransmission. The study of the mechanisms implicated suggests that gut-increased permeability, inflammation, and bacterial translocation of Gram-negative microflora and HSP70 and HGMB1 expression could be potential adjuvant therapeutic targets for the treatment of psychotic and other stress-related psychiatric pathologies.

show abstract

“…In the presence of hyperthermia, ischemia, oxidative stress, and variety of other stressors, expression of HSP70 (especially heat-inducible HSP70-1a, -1b) is highly up-regulated in multiple areas of the brain, and protects against a variety of embryonic insults. Therefore, it was hypothesized that aberrant expression of HSP70 may be linked to structural brain abnormalities observed in schizophrenic patients (Bates et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population

et al. 2019

View full text Add to dashboard Cite

This study aimed to find the potential association between HSPA1B polymorphisms and risk of paranoid schizophrenia, clinical variables of the disease, and suicidal behavior. A total of 901 unrelated Polish subjects of Caucasian origin (377 schizophrenia patients and 524 controls) were recruited. Four single-nucleotide polymorphisms (SNP) were genotyped using PCR-RFLP (rs539689, rs9281590) and TaqMan assays (rs263979, rs6547452). A strong tendency towards statistical significance (p = 0.051) was observed in rs539689 allele distribution between patients and controls in overall study subjects. After stratification according to gender, we found that rs539689 was significantly associated with schizophrenia in males, but not in females. The minor allele C had a protective effect in males [OR 0.73 (95% CI 0.61-0.88, p < 0.05)]. In addition, two SNPs (rs539689, rs9281590) were significantly associated with PANSS scores. Another important finding was a strong significant association between the HSPA1B rs539689 polymorphism and attempted suicide in schizophrenic patients. The C/C genotype and C allele were protective against suicidal behavior in entire sample (p < 0.001), in males (p < 001), and in females (p < 0.05), although associations were weaker than in males. Our findings support that HSPA1B gene may be involved in susceptibility to schizophrenia and clinical presentation of the disease in a sex-dependent manner, and may play a role in suicidal behavior in the Polish population of schizophrenic patients. Further independent analyses in different populations should be performed to clarify the role of HSPA1B in the pathogenesis of schizophrenia.

show abstract

Heat stress lipids and schizophrenia

Cited by 16 publications

References 53 publications

Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population

Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population

Paliperidone Prevents Brain Toll-Like Receptor 4 Pathway Activation and Neuroinflammation in Rat Models of Acute and Chronic Restraint Stress

Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population

Contact Info

Product

Resources

About