Comprehensive Physiology 2015
DOI: 10.1002/cphy.c140017
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Heat Stroke

Abstract: Heat stroke is a life-threatening condition clinically diagnosed as a severe elevation in body temperature with central nervous system dysfunction that often includes combativeness, delirium, seizures, and coma. Classic heat stroke primarily occurs in immunocompromised individuals during annual heat waves. Exertional heat stroke is observed in young fit individuals performing strenuous physical activity in hot or temperature environments. Long-term consequences of heat stroke are thought to be due to a systemi… Show more

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Cited by 360 publications
(382 citation statements)
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References 395 publications
(505 reference statements)
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“…Heat exposure may also alter mental states through thermosensitive physiological processes (Leon & Bouchama, 2015;Page et al, 2007). Emotional wellbeing may diminish because individuals are forced to stay indoors for extended periods, have to alter their daily schedules and face increased cooling expenditures, e.g., due to running air conditioners (Deschênes, 2012).…”
mentioning
confidence: 99%
“…Heat exposure may also alter mental states through thermosensitive physiological processes (Leon & Bouchama, 2015;Page et al, 2007). Emotional wellbeing may diminish because individuals are forced to stay indoors for extended periods, have to alter their daily schedules and face increased cooling expenditures, e.g., due to running air conditioners (Deschênes, 2012).…”
mentioning
confidence: 99%
“…Hyperthermia should quickly be suspected in patients who collapse on hot days, especially if there are factors involved that would impede cooling (2). Our case report illustrates the vulnerability of the brain to high temperatures and shows that diagnosis can be difficult in the first hours and days (1,3,4).…”
Section: Discussionmentioning
confidence: 82%
“…Hyperthermia is defined as a core body temperature above 37.5 ºC, and arises due to inadequate thermoregulation (1,4,5). Symptoms of hyperthermia include varying degrees of tachycardia, hyperventilation, hypotension, feelings of loss of strength/weakness, nausea and dizziness.…”
Section: Discussionmentioning
confidence: 99%
“…[7] This is thought to lead to the multi-organ failure that causes death in severe or untreated cases. [8] Exercise-associated hyponatraemia…”
Section: Heat Strokementioning
confidence: 99%
“…If there is biochemical evidence of rhabdomyolysis, promoting positive fluid balance, diuresis with furosemide, and alkalinisation of urine with sodium bicarbonate can be considered. [7,8] In contrast to fever, there is no role for paracetamol and non-steroidal anti-inflammatory drug use in heat stroke, which may cause further harm. [10] Dantrolene has also not been shown to contribute to management.…”
Section: Hospital Managementmentioning
confidence: 99%