Heat therapy shows benefit in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Sebők, Judit; Édel, Zsófia; Váncsa, Szilárd; Farkas, Nelli; Kiss, Szabolcs; Erőss, Bálint; Török, Zsolt; Balogh, Gábor; Balogi, Zsolt; Nagy, Rita; Hooper, Philip L.; Geiger, Paige C.; Wittmann, István; Vı́gh, László; Dembrovszky, Fanni

doi:10.1080/02656736.2021.2003445

Cited by 14 publications

(13 citation statements)

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“…However, this method and duration of heating did not increase mitochondrial content, nor did it improve fat oxidation, which are typical adaptations that result from exercise training. Even so, building evidence from this work and others [ 22 , 25 ] suggests that heat therapy may be an effective intervention for improving muscle health. Future work should focus on the benefits of different heating modalities, lengths of treatment, and required temperatures to improve mitochondrial health in the context of metabolic disease and disuse.…”

Section: Discussionmentioning

confidence: 64%

“…As previously mentioned, 10 days of short-wave diathermy can mitigate the skeletal muscle atrophy and mitochondrial impairment induced by single-leg immobilization in human subjects [ 25 ]. Furthermore, other methods of inducing heat stress, such as hot water immersion have been shown to improve insulin sensitivity and glucose management in both type 2 diabetic human subjects [ 22 , 66 ], as well as various animal models [ 21 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, acutely raising core and muscle temperature using a water-perfused suit activates signaling pathways associated with mitochondrial biogenesis and angiogenesis [ 20 ]. Furthermore, growing evidence suggests that mild heat stress can improve glucose management and other cardiometabolic parameters associated with insulin resistance and diabetes, some of which may be mediated by improved mitochondrial health [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fatty Acid Oxidation

Marchant

Kaluhiokalani²,

Wallace³

et al. 2022

IJMS

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AIM: Mild heat stress can improve mitochondrial respiratory capacity in skeletal muscle. However, long-term heat interventions are scarce, and the effects of heat therapy need to be understood in the context of the adaptations which follow the more complex combination of stimuli from exercise training. The purpose of this work was to compare the effects of 6 weeks of localized heat therapy on human skeletal muscle mitochondria to single-leg interval training. METHODS: Thirty-five subjects were assigned to receive sham therapy, short-wave diathermy heat therapy, or single-leg interval exercise training, localized to the quadriceps muscles of the right leg. All interventions took place 3 times per week. Muscle biopsies were performed at baseline, and after 3 and 6 weeks of intervention. Mitochondrial respiratory capacity was assessed on permeabilized muscle fibers via high-resolution respirometry. RESULTS: The primary finding of this work was that heat therapy and exercise training significantly improved mitochondrial respiratory capacity by 24.8 ± 6.2% and 27.9 ± 8.7%, respectively (p < 0.05). Fatty acid oxidation and citrate synthase activity were also increased following exercise training by 29.5 ± 6.8% and 19.0 ± 7.4%, respectively (p < 0.05). However, contrary to our hypothesis, heat therapy did not increase fatty acid oxidation or citrate synthase activity. CONCLUSION: Six weeks of muscle-localized heat therapy significantly improves mitochondrial respiratory capacity, comparable to exercise training. However, unlike exercise, heat does not improve fatty acid oxidation capacity.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fatty Acid Oxidation

Marchant

Kaluhiokalani²,

Wallace³

et al. 2022

IJMS

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“…We performed a systematic review and meta-analysis to evaluate the already published trials on this topic. The results of which were used in the planning of this trial 24…”

Section: Methods and Analysismentioning

confidence: 99%

“…The results of which were used in the planning of this trial. 24 Patient and public involvement Three patients who would have been eligible for the study with T2DM were invited to the study protocol development. All were provided detailed information on the study, including the complete protocol.…”

Section: Study Protocol Developmentmentioning

confidence: 99%

Effect of HEAT therapy in patiEnts with type 2 Diabetes mellitus (HEATED): protocol for a randomised controlled trial

et al. 2022

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IntroductionThe burden of type 2 diabetes mellitus (T2DM) is increasing worldwide. Heat therapy has been found effective in improving glycaemic control. However, to date, there is a lack of randomised controlled studies investigating the efficacy of heat therapy in T2DM. Therefore, we aim to investigate whether heat therapy with natural thermal mineral water can improve glycaemic control in patients with T2DM.Methods and analysisThe HEAT therapy in patiEnts with type 2 Diabetes mellitus (HEATED) Study is a single-centre, two-arm randomised controlled trial being conducted at Harkány Thermal Rehabilitation Centre in Hungary. Patients with T2DM will be randomly assigned to group A (bath sessions in 38°C natural thermal mineral water) and group B (baths in thermoneutral water (30°C–32°C)). Both groups will complete a maximum of 5 weekly visits, averaging 50–60 visits over the 12-week study. Each session will last 30 min, with a physical check-up before the bath. At baseline, patients’ T2DM status will be investigated thoroughly. Possible microvascular and macrovascular complications of T2DM will be assessed with physical and laboratory examinations. The short form-36 questionnaire will assess the quality of life. Patients will also be evaluated at weeks 4, 8 and 12. The primary endpoint will be the change of glycated haemoglobin from baseline to week 12. An estimated 65 patients will be enrolled per group, with a sample size re-estimation at the enrolment of 50% of the calculated sample size.Ethics and disseminationThe study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (818-2/2022/EÜIG). Written informed consent is required from all participants. We will disseminate our results to the medical community and will publish our results in peer-reviewed journals.Trial registration numberClinicalTrials.gov, NCT05237219.

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Passive heat stress induces mitochondrial adaptations in skeletal muscle

Marchant

Nelson

Hyldahl

et al. 2023

International Journal of Hyperthermia

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Heat therapy shows benefit in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Cited by 14 publications

References 58 publications

Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fatty Acid Oxidation

Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fatty Acid Oxidation

Effect of HEAT therapy in patiEnts with type 2 Diabetes mellitus (HEATED): protocol for a randomised controlled trial

Passive heat stress induces mitochondrial adaptations in skeletal muscle

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