Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations

Hu, Huan; Nakagawa, Tohru; Honda, Takeshi; Yamamoto, S.; Miyamoto, Toshiaki; Okazaki, Hiroko; Eguchi, M.; Shirasaka, Taiki; Kochi, Takeshi; Kabe, Isamu; Tomizawa, Aki; Miki, Takako; Fukunaga, Ami; Yamamoto, Shohei; Inoue, Yosuke; Konishi, Maki; Miyake, Haruka; Dohi, Seitaro; Mizoue, Tetsuya

doi:10.1038/s41598-022-22337-3

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…In randomized studies, HNB products, like traditional cigarettes or e-cigarettes, increase oxidative stress; however, the dysfunction of the vascular endothelium they cause is significantly lower than in the case of the former [16]. Heated tobacco products users have a lower HDL-C cholesterol concentration, which is lower than in people who have never smoked, but higher than in smokers of traditional cigarettes [17].…”

Section: Discussionmentioning

confidence: 97%

E-cigarettes and tobacco heaters – a healthier alternative or another threat. Literature review

Gacoń,

Kotusiewicz,

Siekierko

et al. 2023

Med Srod.

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Introduction and Objective. Nicotinism has been one of the most common addictions for many years. Tobacco smoking, both active and passive, is a serious social problem. In recent years, alternatives to conventional cigarettes have appeared on the market. The aim of the review is to analyze the latest publications available in PubMed and Google Scholar on the impact of e-cigarettes and tobacco heaters on health, in comparison with conventional tobacco products. Brief description of the state of knowledge. The commonly prevailing myth about the lower harmfulness of these products is being refuted more and more often. In many cases, they have a similar effect to traditional cigarettes on the organs, inter alia interfering with the functioning of the circulatory and respiratory systems. Due to the high concentration of nicotine, they can interfere with the development of the central nervous system, and their impact on fertility has also become the subject of research. It is extremely important for the health of the young generation due to the increasingly frequent use of these products by adolescents and young adults. E-cigarettes are not without impact on health and although in some aspects they may cause less organ toxicity than traditional cigarettes, it is extremely disturbing that they can lead to diseases that were not previously associated with nicotinism, e.g. by disturbing the proper functioning of the liver. Summary. When reviewing scientific papers, many ambiguities and even contradictions in the assessment of the risk of using these products are still found. Although the overall assessment of health effects indicates their possible harmfulness, their potential use in the treatment of nicotinism cannot be overlooked.

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Section: Discussionmentioning

confidence: 97%

E-cigarettes and tobacco heaters – a healthier alternative or another threat. Literature review

Gacoń,

Kotusiewicz,

Siekierko

et al. 2023

Med Srod.

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“…16 Furthermore, they have an increased likelihood, ranging between 25% (OR: 1.25; 95% CI: 1.09-1.43) and 80% (aOR: 1.80; 95% CI: 1.45-2.23), of having significantly lower HDL concentration than never smokers. 16,53 Finally, ecigarette use is associated with an approximately 2.05 (95% CI: 1.03-4.08) likelihood of high BP, as well as abdominal obesity. 16,50 Collectively, the above reveal the detrimental long-term impacts of e-cigarette use on cardiometabolic health, which are mediated by changes in peripheral and central hemodynamics, BP, carotid-femoral pulse-wave velocity, and thrombotic events, and may ultimately increase the long-term risk of CVD such as peripheral arterial disease and/ or other thrombotic-related outcomes.…”

Section: Discussionmentioning

confidence: 99%

Impact of Electronic Cigarette use on Cardiovascular Health: Current Evidence, Causal Pathways, and Public Health Implications

Critselis

Panagiotakos

2023

Angiology

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Electronic cigarette (e-cigarette) use is increasing in Europe and the USA. While mounting evidence exists regarding an array of associated adverse health effects, to date limited evidence exists regarding the health effects of e-cigarette use on cardiovascular (CV) disease (CVD). The present review summarizes the effects of e-cigarette use on CV health. A search strategy of in vivo experimental, observational studies (including population-based cohort studies), and interventional studies was conducted in PubMed, MEDLINE, and Web of Science (April 1, 2009–April 1, 2022). The main findings revealed that the influence of e-cigarette on health are attributed mainly to the individual and interactive effects of flavors and additives used in e-cigarette fluids, along with the extended heating. The above collectively stimulate prolonged sympathoexcitatory CV autonomic effects, such as increased heart rate and diastolic blood pressure (BP), as well as decreased oxygen saturation. Hence, e-cigarette users are at increased risk of developing atherosclerosis, hypertension, arrhythmia, myocardial infarction, and heart failure. Such risks are anticipated to increase, especially among the young who are increasingly adopting e-cigarette use particularly with flavored additives. Further investigations are urgently needed to evaluate the long-term effects of e-cigarette use, particularly among susceptible population groups such as youth.

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“…Consequently, we excluded e-cigarette users (n=116) from our analysis. The remaining participants were divided into five groups: never smokers, former smokers, exclusive HTP users, dual users of cigarettes and HTPs, and exclusive cigarette smokers, as in previous publications 13 , 14 .…”

Section: Methodsmentioning

confidence: 99%

Association of conventional cigarette smoking, heated tobacco product use, and dual use with hearing loss: A working population-based study

Hu,

Miyake,

Kochi

et al. 2024

Tob. Induc. Dis.

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INTRODUCTION Although conventional cigarette smoking has been linked to an increased risk of hearing loss, the association between heated tobacco products (HTPs) and hearing loss is unknown. The objective of this study was to investigate the association between cigarette and HTP use and hearing loss. METHODS This cross-sectional study examined the data of 7769 employees from five companies (Study I) and 34404 employees from a large company (Study II), all participants in the Japan Epidemiology Collaboration on Occupational Health Study. The participants were categorized into five groups based on their self-reported tobacco use: never smokers, former smokers, exclusive cigarette smokers, exclusive users of HTPs, and those who used both cigarettes and HTPs. Hearing levels were measured using pure-tone audiometry at 1 and 4 kHz frequencies. Separate analyses were carried out for each study, and the results were then combined using fixed-effect models to pool the estimates. RESULTS The analysis included 42173 participants, with a prevalence of 12.9% for exclusive cigarette smoking, 9.8% for exclusive HTP use, and 5.5% for dual use. The pooled adjusted odds ratios with 95% confidence intervals for unilateral hearing loss at 4 kHz were 1.21 (95% CI: 1.10–1.33) for former smokers, 1.83 (95% CI: 1.64–2.05) for exclusive cigarette smokers,1.46 (95% CI: 1.28–1.67) for exclusive HTP users, and 1.66 (95% CI: 1.41–1.96) for dual users, compared to never smokers. Additionally, the adjusted odds ratios for hearing loss at 4 kHz among exclusive cigarette smokers, exclusive HTP users, and dual users increased with the intensity of cigarette/HTP consumption (all p for trend <0.001). No significant associations were found between exclusive HTP use, dual use, and hearing loss at 1 kHz, apart from exclusive cigarette smoking. CONCLUSIONS In this cross-sectional study, associations were found between exclusive cigarette smoking, exclusive HTP use, dual use, and hearing loss, particularly at 4 kHz. Further research is needed to confirm these findings.

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Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations

Cited by 5 publications

References 19 publications

E-cigarettes and tobacco heaters – a healthier alternative or another threat. Literature review

E-cigarettes and tobacco heaters – a healthier alternative or another threat. Literature review

Impact of Electronic Cigarette use on Cardiovascular Health: Current Evidence, Causal Pathways, and Public Health Implications

Association of conventional cigarette smoking, heated tobacco product use, and dual use with hearing loss: A working population-based study

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