Heavy atom free 1,1,4,4-tetraphenylbuta-1,3-diene with aggregation induced emission for photodynamic cancer therapy

Wen, Huijuan; Ma, Juan; Chen, Jianjiao; Ke, Zhen; Zou, Dengfeng; Li, Qiaoyun

doi:10.1039/c9nj01331h

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Applications Of 13-diene-based Aiegens1

Nanoparticles1

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2024

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Cited by 8 publications

(2 citation statements)

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“…Subsequent in vivo investigations evaluated its efficacy and organ toxicity, revealing minimal toxicities and significant cancer cell inhibition. 149 …”

Section: Applications Of 13-diene-based Aiegensmentioning

confidence: 99%

1,3-diene-based AIEgens: Stereoselective synthesis and applications

Nong,

Gu,

Zhai

et al. 2024

iScience

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“…Subsequent in vivo investigations evaluated its efficacy and organ toxicity, revealing minimal toxicities and significant cancer cell inhibition. 149 …”

Section: Applications Of 13-diene-based Aiegensmentioning

confidence: 99%

1,3-diene-based AIEgens: Stereoselective synthesis and applications

Nong,

Gu,

Zhai

et al. 2024

iScience

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“…To enhance the tumor passive targeting efficiency, a series of strategies have been adopted to modify AIEgens, including polyethylene glycol (PEG), [55][56][57] micelles, [58][59][60] and liposomes. [61] PEG is used widely in the modifica-tion of nanoparticles to prolong their systemic circulation time by protecting them from aggregation, opsonization, and phagocytosis.…”

Section: Nanoparticlesmentioning

confidence: 99%

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

et al. 2023

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Cancer is one of the most fatal diseases for decades. Aggregation‐induced emission luminogens (AIEgens) have been recently used as molecular imaging or therapeutic agents in cancers, due to the advantages of large Stokes shift, high quantum yield, great biocompatibility, and strong photostability. AIEgens can specifically target different types of cancer via diverse targeting strategies. AIEgen‐based fluorescence imaging, especially near‐infrared imaging, demonstrated deep penetration and suitable signal‐to‐noise ratio, which allows reliable in vivo cancer imaging. Combined with other imaging modalities, AIEgen‐based multimodal imaging could provide multidimensional cancer hallmarks from different perspectives. In addition, AIEgen‐based phototherapy can be used for photodynamic therapy and photothermal therapy, which facilitate ablation of cancer cells with good biosafety and high therapeutic effects in vivo. AIEgens nanoparticles fabricated with some specific chemicals, drugs, or siRNA, could display synergistic therapeutic effects for cancers. This paper comprehensively describes the current status and future perspectives of AIEgens, which have showed a great potential for the future preclinical and clinical translation on in vivo molecular imaging and theranostics in cancer.

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Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

Chen

Wang

Yuan

et al. 2022

Engineered Regeneration

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Heavy atom free 1,1,4,4-tetraphenylbuta-1,3-diene with aggregation induced emission for photodynamic cancer therapy

Abstract: Common organic molecules usually suffer from aggregation caused quenching (ACQ), which is disadvantageous for imaging guided phototherapy.

Cited by 8 publications

References 33 publications

1,3-diene-based AIEgens: Stereoselective synthesis and applications

1,3-diene-based AIEgens: Stereoselective synthesis and applications

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

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