Heavy metal exposure in patients suffering from electromagnetic hypersensitivity

Ghezel-Ahmadi, David; Engel, Alice; Weidemann, Jörg; Budnik, Lygia Therese; Baur, Xaver; Frick, Ulrich; Hauser, Simone; Dahmen, Norbert

doi:10.1016/j.scitotenv.2009.11.023

Cited by 12 publications

(10 citation statements)

References 36 publications

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“…No entirely convincing hypothesis on mode of action has been proposed and proven so far, while provocation studies have provided uncertain results. Data about specific heavy metal blood concentrations of cadmium, mercury and lead in EHS subjects [79] appear relevant, especially in the frame of the considerable overlapping of symptoms with amalgam disease, as related to chronic fatigue, headaches, general malaise and insomnia, although intoxication levels reported are below toxic concentrations. Also in this case, methodological doubts concerning biological samples analyzed, not necessarily representative of effective tissue and organ loads [80], raise the alarm that even negligible metal concentrations may be actively mobilized from tissue under EMF exposure, and exert immuno-toxic effects, with inflammatory cytokine hyper-production and release.…”

Section: Controversial Case Definitionsmentioning

confidence: 99%

The Search for Reliable Biomarkers of Disease in Multiple Chemical Sensitivity and Other Environmental Intolerances

Luca

Raskovic

Pacifico

et al. 2011

IJERPH

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Whilst facing a worldwide fast increase of food and environmental allergies, the medical community is also confronted with another inhomogeneous group of environment-associated disabling conditions, including multiple chemical sensitivity (MCS), fibromyalgia, chronic fatigue syndrome, electric hypersensitivity, amalgam disease and others. These share the features of poly-symptomatic multi-organ cutaneous and systemic manifestations, with postulated inherited/acquired impaired metabolism of chemical/physical/nutritional xenobiotics, triggering adverse reactions at exposure levels far below toxicologically-relevant values, often in the absence of clear-cut allergologic and/or immunologic involvement. Due to the lack of proven pathogenic mechanisms generating measurable disease biomarkers, these environmental hypersensitivities are generally ignored by sanitary and social systems, as psychogenic or “medically unexplained symptoms”. The uncontrolled application of diagnostic and treatment protocols not corresponding to acceptable levels of validation, safety, and clinical efficacy, to a steadily increasing number of patients demanding assistance, occurs in many countries in the absence of evidence-based guidelines. Here we revise available information supporting the organic nature of these clinical conditions. Following intense research on gene polymorphisms of phase I/II detoxification enzyme genes, so far statistically inconclusive, epigenetic and metabolic factors are under investigation, in particular free radical/antioxidant homeostasis disturbances. The finding of relevant alterations of catalase, glutathione-transferase and peroxidase detoxifying activities significantly correlating with clinical manifestations of MCS, has recently registered some progress towards the identification of reliable biomarkers of disease onset, progression, and treatment outcomes.

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Section: Controversial Case Definitionsmentioning

confidence: 99%

The Search for Reliable Biomarkers of Disease in Multiple Chemical Sensitivity and Other Environmental Intolerances

Luca

Raskovic

Pacifico

et al. 2011

IJERPH

View full text Add to dashboard Cite

show abstract

“…In this case, linearly increasing distribution reduces the reflected power much more than the other distribution functions up to 33 GHz. [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] GHz range, sinusoidal and linearly decreasing functions are more useful in terms of small reflection. Fig.…”

Section: Resultsmentioning

confidence: 99%

“…that is zero at  t T , the following equality holds: (44) it is possible to show that every term in (43) is nonnegative (Mikhailov, 1976) and therefore   , u g t is equal to zero for all   int g and   0 t T , which means that the solution to the problem (42) is unique. This proves the equivalency of the two problems.…”

Section: On the Equivalence Of The Initial Problem And The Problem Wimentioning

confidence: 99%

“…Heavy metals bound the proteins within tissues and organs are thought to have low toxicity. Mortazavi and coworkers have found that static magnetic field as well as microwave radiation emitted from mobile phones may induced the mercury vapor release from dental amalgam, increasing concentration of dissolved mercury in saliva among amalgam bearers (43,44,45).…”

Section: Heavy Metals Exposure and Electromagnetic Hypersensitivitymentioning

confidence: 99%

“…Transmembrane proteins form a physical barrier (43). BBB tightness is provided by the connective tissue cells called pericytes and the extracellular matrix of the basement membrane (44).…”

Section: Electromagnetic Fields and Blood-brain Barriermentioning

confidence: 99%

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Quasi-optical Systems Based on Periodic Structures

Vorobjov¹,

Shulga²,

Zhurbenko³

2011

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Disturbed sleep in individuals with idiopathic environmental intolerance attributed to electromagnetic fields (IEI‐EMF): Melatonin assessment as a biological marker

Andrianome

Hugueville

Seze

et al. 2016

Bioelectromagnetics

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Individuals who suffer from idiopathic environmental intolerance attributed to electromagnetic fields (IEI‐EMF) complain of a variety of adverse health effects. Troubled sleep remains a recurrent and common symptom in IEI‐EMF individuals. Melatonin, a circadian hormone, plays a major role in the sleep process. In this study, we compared levels of melatonin between a sensitive group (IEI‐EMF, n = 30) and a non‐sensitive control group (non IEI‐EMF, n = 25) without exposure to electromagnetic sources. Three questionnaires were used to evaluate the subjective quality and sleep quantity: the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index and the Spiegel Sleep Inventory. Melatonin was quantified in saliva and its major metabolite 6‐sulfatoxymelatonin (aMT6s) in urine. Melatonin levels were compared by a two‐way analysis of variance at various times between the control and IEI‐EMF group. Despite significantly different sleep scores between the two groups, with a lower score in the IEI‐EMF group (P < 0.001), no statistical difference was found between the two groups for saliva melatonin (P > 0.05) and urine aMT6s (P > 0.05). Bioelectromagnetics. 37:175–182, 2016. © 2016 Wiley Periodicals, Inc.

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Heavy metal exposure in patients suffering from electromagnetic hypersensitivity

Cited by 12 publications

References 36 publications

The Search for Reliable Biomarkers of Disease in Multiple Chemical Sensitivity and Other Environmental Intolerances

The Search for Reliable Biomarkers of Disease in Multiple Chemical Sensitivity and Other Environmental Intolerances

Quasi-optical Systems Based on Periodic Structures

Disturbed sleep in individuals with idiopathic environmental intolerance attributed to electromagnetic fields (IEI‐EMF): Melatonin assessment as a biological marker

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