Heavy metals and glutathione metabolism in mussel tissues

Energy allocations to xenobiotic transport and biotransformation reactions in rainbow trout (Oncorhynchus mykiss) during energy intake restriction

“…copper, mercury, iron) from mining and other industrial activities can both donate and accept electrons, making them capable of bonding with nucleophilic targets of thiol and amine groups in proteins and nucleic acids in cells, as well as reacting with peroxides to form extremely reactive hydroxyl radicals (Canesi et al 1999;Schlenk 2001). A reduced GST activity in teleost fish would likely affect the ability of the enzyme to conjugate glutathione to lipid peroxidation products from metalinduced ROS generation.…”

“…A reduced GST activity in teleost fish would likely affect the ability of the enzyme to conjugate glutathione to lipid peroxidation products from metalinduced ROS generation. Furthermore, transition metals can form stable complexes with glutathione, preventing their ability to generate ROS and enhancing their excretion, if the underlying cause of decreased GST activity during fasting is a depletion of reduced glutathione these protective mechanisms may be attenuated in fish (Canesi et al 1999;Cajaraville et al 2003).…”

Influence of gender and season on reduced glutathione concentration and energy reserves of Gammarus roeseli

“…It also plays an important role as a reducer which could prevent the toxic effect of ROS (Meister, 1988). Its contents have therefore been assayed in ecotoxicological studies about invertebrates, especially in bivalves Canesi et al, 1999;Romero-Ruiz et al, 2003).…”

Physiological, Immunological, Genotoxic and Histopathological Biomarker Responses of Molluscs to Heavy Metal and Water-Quality Parameter Exposures: A Critical Review

“…Canesi et al [54] reported a reduction in glutathione-S-hydroxylase, GSH, after exposing Mytilus spp. to copper concentration for a day.…”