Heavy metals in liquid pig manure in light of bacterial antimicrobial resistance

Hölzel, Christina; Müller, Christa E.; Harms, Katrin; Mikolajewski, Sabine; Schäfer, Stefanie; Schwaiger, Karin; Bauer, Johann

doi:10.1016/j.envres.2012.01.002

Cited by 179 publications

(113 citation statements)

References 42 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Lower tetracycline concentration was detected in lettuce planted soil than in controlled soil at 30 d, which may be related to an accelerated dissipation in rhizosphere soil due to plant-enhanced microbial biotransformation processes [29,30]. In addition, heavy metals were also detected in manure-amended soil, which might further enhance the dissemination of antibiotic resistance by co-selection with antibiotics, as observed for copper and zinc [31,32]. Long-term and cumulative inputs of antibiotics and heavy metals and their presence can potentially affect the acquisition and maintenance of ARGs in the environment [11,33].…”

Section: Discussionmentioning

confidence: 87%

Antibiotic resistance genes in manure-amended soil and vegetables at harvest

Wang

Qiao

Chen

et al. 2015

Journal of Hazardous Materials

285

110

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 87%

Antibiotic resistance genes in manure-amended soil and vegetables at harvest

Wang

Qiao

Chen

et al. 2015

Journal of Hazardous Materials

285

110

View full text Add to dashboard Cite

“…Studies have shown that Zn and Cu used at high concentrations for a longer period might promote the spread of antimicrobial resistance of gut microflora in pigs (Holzel et al 2012). It was demonstrated that prolonged exposure to pharmacological doses of Zn can increase the resistance in some form of microbes e.g.…”

Section: Antimicrobial Resistancementioning

confidence: 99%

Supplementation of pigs diet with zinc and copper as alternative to conventional antimicrobials

Debski¹

2016

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Modern commercial pig farming systems inflict increased stress in animals, which often leads to various negative changes in the gastro-intestinal tract, especially in the case of piglets. Ban of antibiotics, used as growth promoters, has caused a need for alternatives to conventional antimicrobials in swine diets. Use of pre-/or probiotics, organic acids and plant extracts is often recommended, but it seems that zinc oxide and cooper salts, which were traditionally included in high doses to piglets diet, possess the highest efficacy. In commercial conditions feeding piglets with high doses of Zn and/or Cu stimulates piglets daily gain and decreases feed conversion factor. However, as heavy metals Zn and Cu tend to accumulate in soil and cause serious environmental pollution of soil and tap-water. Furthermore, high zinc concentrations (2500÷3000 mg/kg feed) in feed may have an impact on development of antimicrobial resistance, and may regulate the expression of genes that modify piglets' immune response. Therefore, the use of high doses of ZnO and/or Cu salts, as growth promoter, has always been a subject of discussion, and caused different legal status of such treatment in various EU countries. This short review describes current European Food Safety Authority (EFSA) point of view on the use of ZnO in medicated feed. The higher bioavailability of recently introduced new sources or forms of these metals allows for substantial reduction of dietary inclusion rate, which should have a positive outcome for pigs health and the environment.

show abstract

“…Therefore, several approaches have been adopted to study heavy-metalresistance mechanisms in microorganisms, and implement them in heavy-metal bioremediation since microbial bioremediation techniques are economically viable and ecofriendly (Holzel et al, 2012;Viti et al, 2014). Our investigation clearly demonstrated that the Cd 2+ resistant Pseudomonas aeruginosa strain Pse-w could promote plant growth significantly.…”

Section: Discussionmentioning

confidence: 59%

Isolation and engineering of plant growth promoting rhizobacteria <i>Pseudomonas aeruginosa</i> for enhanced cadmium bioremediation

Huang¹,

Liu²,

et al. 2016

J. Gen. Appl. Microbiol.

View full text Add to dashboard Cite

Although many bacteria are tolerant to heavy metals and play important roles in the immobilization of heavy metals, they cannot always be dependably reproduced under field conditions. In this work, a cadmium (Cd)-resistant bacterium was isolated from a Cd-contaminated oil field and identified as Pseudomonas aeruginosa (Pse-w). We then determined various plant growth promoting features such as the solubilization of phosphate, and the production of indole-3-acetic acid and siderophores. Lastly, we engineered the strain Psew-MT by targeting metallothioneins to the cell surface of Pse-w to immobilize Cd 2+ and promote plant growth. Our data revealed that Pse-w exhibited high levels of resistance to Cd 2+ (4 mM) and showed various plant growth promoting features. The engineered strain Pse-w-MT was found to adsorb Cd 2+ mainly via extracellular deposition, and had an enhanced ability for immobilizing Cd 2+ ions from the external media. Furthermore, the inoculation of Cd-polluted soil with Pse-w-MT significantly elevated the shoot and root biomass and leaf chlorophyll content. Similarly, plants inoculated with Psew-MT demonstrated markedly lower Cd 2+ accumulation in the root and shoot system. It was concluded that plant growth promoting rhizobacteria with a high Cd 2+ tolerance was an ideal candidate to be engineered for bioremediation and plant growth promotion against Cd-induced stress.

show abstract

Heavy metals in liquid pig manure in light of bacterial antimicrobial resistance

Cited by 179 publications

References 42 publications

Antibiotic resistance genes in manure-amended soil and vegetables at harvest

Antibiotic resistance genes in manure-amended soil and vegetables at harvest

Supplementation of pigs diet with zinc and copper as alternative to conventional antimicrobials

Isolation and engineering of plant growth promoting rhizobacteria <i>Pseudomonas aeruginosa</i> for enhanced cadmium bioremediation

Contact Info

Product

Resources

About