Heavy metals in organs of stray dogs and cats from the city of Naples and its surroundings (Southern Italy)

Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology

“… 2 This mechanism also has been proposed for hepatic accumulation of Pb, which has been studied in acute exposure in rodents 25 and, in both acute as well as chronic environmental exposure, in small animals. 8 , 14 , 15 , 16 , 21 , 22 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 In all of the scenarios described above, the simultaneous presence of Pb and Cu within the hepatocyte and the subsequent hepatic injury may trigger inflammation and oxidative stress. 2 , 39 In particular, oxidative stress is thought to be the main mechanism of hepatic injury caused by Pb.…”

“…Regarding Pb, in the last decade, domestic and wild animals have been studied as sentinels for toxicological risk assessment of humans. 15 , 16 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 Companion animals especially have been studied as potential sentinels for environmental Pb exposure, because they share much of the same environment with people, and may even be more exposed than their owners to several contaminants (water, soil). 16 , 21 , 22 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 However, the majority of the these studies have been conducted on blood [Pb], in order to establish Pb exposure.…”

“… 15 , 16 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 Companion animals especially have been studied as potential sentinels for environmental Pb exposure, because they share much of the same environment with people, and may even be more exposed than their owners to several contaminants (water, soil). 16 , 21 , 22 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 However, the majority of the these studies have been conducted on blood [Pb], in order to establish Pb exposure. 15 , 21 , 22 , 27 , 29 The other studies, which performed [Pb] assessments in various organs, in particular the liver and kidneys, consisted of necropsy evaluations without any comparison with clinicopathological variables.…”

“…3,15 Data regarding hepatic Pb concentrations ([Pb]) in dogs are scarce. 9,10,[16][17][18][19] In dogs, hepatic [Pb] mainly has been investigated as a sentinel for human exposure to heavy metals, 10,16,19 but hepatic [Pb] recently was taken into account in dogs with hepatocellular carcinoma. 9 We hypothesized that, in addition to [Cu], hepatic [Pb] also may play a role in hepatocellular injury and may be responsible for hematologic or histological alterations or both.…”

“…Data regarding hepatic Pb concentrations ([Pb]) in dogs are scarce. 9 , 10 , 16 , 17 , 18 , 19 In dogs, hepatic [Pb] mainly has been investigated as a sentinel for human exposure to heavy metals, 10 , 16 , 19 but hepatic [Pb] recently was taken into account in dogs with hepatocellular carcinoma. 9 …”