Hedgehog signal expression in articular cartilage of rat temporomandibular joint and association with adjuvant‐induced osteoarthritis

Xu, Ting; Xu, Guohai; Gu, Zhiyuan; Wu, Huiling

doi:10.1111/jop.12497

Cited by 16 publications

(26 citation statements)

References 28 publications

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“…Повышенный уровень экспрессии ММП-1 при ПКШМ может рассматриваться как фактор плохого прогноза для пациента. Экспрессия ММП-1 и регуляторов её активности может происходить (индуцироваться) и в морфологически нормальной ткани матки, по-видимому, по типу эпителиально-мезенхимального взаимодействия [20,21].…”

Section: результаты и обсуждениеunclassified

Interstitial collagenase and their endogenous regulators in squamous cell cervical carcinoma

Timoshenko

Kugaevskaya

et al. 2017

BIOMED KHIM

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Interstitial collagenase (MMP-1) belongs to the family of matrix metalloproteinases (MMP), which play a key role in generalization processes of invasion and metastasis, which determine the degree of tumor malignancy. MMP-1 refers to secreted, inducible MMP, the expression of which in normal tissues is not defined. Induction of expression of MMP in CSS in the tumor occurs under the action of oncogenes of HPV, and in areas adjacent to the tumor normal tissue under the action of the inductor expression of MMP - EMMPRIN (CD147), which expressively on the surface of tumor cells. The aim of this study is to determine the possibility of expression ofMMP-1 and its regulators (tissue inhibitors TIMP-1 and activator - plasminogen activator - ADF) in morphologically normal body of the uterus during CSS. The study was carried out using on a tissue "tape" - postoperative specimens of the uterus when the diagnosis of CSS. All of the samples was expressed HPV16 gene E7. It was shown that: 1. The increase of MMP-1 expression, low expression (or lack thereof) of its inhibitors TIMP-1 and a very clear expression of the activator take place in the tumor when CSS that lead to increased activity of MMP-1, and aims to increase the destructive (invasive) potential of the tumor. 2. In morphologically normal tissue of the uterus during CSS the expression of MMP-1 can occur from the vaginal wall to the bottom of the uterine cavity, but at a much lower level than in the tumor. 3. These data indicate the possibility of development of a destructive process in morphologically normalnyh body tissues of the uterus during CSS, important for understanding the mechanism of tumor progression, and suggest participation in the process of expression of MMP-1 signaling by the type of epithelial-mesenchymal interaction .

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Section: результаты и обсуждениеunclassified

Interstitial collagenase and their endogenous regulators in squamous cell cervical carcinoma

Timoshenko

Kugaevskaya

et al. 2017

BIOMED KHIM

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“…However, IHH signalling has been linked to cartilage degeneration in TMJOA. Xu et al 16 verified an association between Ihh levels and the severity of articular cartilage destruction in the TMJ of OA‐induced rats. Moreover, BMP and IHH roles in OA cartilage appear to be intimately connected.…”

Section: Discussionmentioning

confidence: 96%

“…Indian hedgehog (IHH) is a member of a protein family that participates in chondrocyte proliferation and differentiation, playing major roles in TMJ development 16 . However, IHH signalling has been linked to cartilage degeneration in TMJOA.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the current understanding of OA basic physiopathology, the biomolecular mechanisms involved in TMJOA have not been fully clarified to this day in humans. Results from animal studies and research on other joints from the appendicular skeleton may be extrapolated, but the human TMJ has unique structural and biomolecular features that include morphogenesis and repair processes, cartilage composition and specific cytokine patterns 13,16,17 . Therefore, the aim of this study was to evaluate histopathological changes, collagen degeneration and the expression of eleven anabolic, catabolic and mixed effect biomarkers of TMJOA in articular discs from patients treated by discectomy.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical panel of degenerated articular discs from patients with temporomandibular joint osteoarthritis

Fernandes

Brancher

Michels

et al. 2020

J of Oral Rehabilitation

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Background Temporomandibular joint osteoarthritis (TMJOA) is a progressive degenerative disease caused by imbalance between anabolic and catabolic stimuli. Objective The aim of this study was to evaluate histopathological changes, collagen degeneration and the expression of eleven TMJOA biomarkers in articular discs. Methods Specimens were obtained from eight female patients submitted to discectomy. Discs were divided into anterior band (AB), intermediate zone (IZ) and posterior band (PB) for computerised histomorphometric analyses. Each was assigned a histopathological degeneration score (HDS). Collagen degeneration was assessed with Picrosirius‐polarisation method. Biomarkers were evaluated through immunohistochemistry, including IGF‐1, OPG, VEGF, TNF‐α, FGF‐23, IHH, MMP‐3, MMP‐9, TGF‐β1, BMP‐2 and WNT‐3. Image processing software was used to calculate average immature collagen ratios and immunostained areas. Spearman rank tests were applied to verify correlations, with significance level of 0.05. Results The HDS showed negative correlation with expression of VEGF in IZ and PB (P < .05) and positive with TNF‐α in AB (P < .01). Collagen degeneration correlated with TGF‐β1 (P < .05), BMP‐2 (P < .01) and IHH (P < .05) immunostained areas in the IZ; TGF‐β1, BMP‐2 and IHH expression correlated among each other in AB and IZ (P < .05). Conclusion Angiogenesis and tissue fragmentation may result from aberrant physiologic responses mediated by VEGF and TNF‐α, compromising TMJ discs during OA progression. The expression of TGF‐β1, BMP‐2 and IHH could be related to collagen degeneration in displaced discs and may participate in TMJOA pathogenesis.

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“…Es el mediador de la mecanotransducción en el cartílago condilar que detecta la tensión mecánica y la convierte en crecimiento 30 . Es el factor mecano-sensible más dinámico expresado en condrocitos y necesario para su proliferación 20,41 . Se regula positivamente por PTHrP durante la formación de hueso endocondral y es sintetizado por condrocitos que salen de la zona proliferativa.…”

Section: Tablaunclassified

Crecimiento del cartílago condilar. Una revisión de la literatura

Peláez

Murillo

Parada

2018

Odontol. sanmarquina

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El cóndilo mandibular es un cartílago secundario caracterizado por su respuesta a cargas funcionales y mecánicas. Su estimulación repetida desencadena una serie de eventos que parecen aumentar el número de células mesenquimales de replicación. En esta revisión de la literatura se presentan los hallazgos fundamentales para comprender los factores que condicionan el crecimiento condilar. Se analizaron los siguientes tópicos asociados: embriología, influencia genética y ambiental, función como centro de crecimiento y la bioingeniería aplicada a este campo. Se evidenció en la literatura revisada que el cóndilo actúa como principal centro de crecimiento adaptativo regional y que la regulación del desarrollo está determinada por factores genéticos y epigenéticos que modifican la expresión de factores de transcripción y crecimiento.

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Hedgehog signal expression in articular cartilage of rat temporomandibular joint and association with adjuvant‐induced osteoarthritis

Abstract: These results indicate that the activation of Ihh signaling may be correlated with pathological changes of condylar cartilage in adjuvant-induced TMJOA.

Cited by 16 publications

References 28 publications

Interstitial collagenase and their endogenous regulators in squamous cell cervical carcinoma

Interstitial collagenase and their endogenous regulators in squamous cell cervical carcinoma

Immunohistochemical panel of degenerated articular discs from patients with temporomandibular joint osteoarthritis

Crecimiento del cartílago condilar. Una revisión de la literatura

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