Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon

Scholpp, Steffen; Wolf, Olivia; Brand, Michael; Lumsden, Andrew

doi:10.1242/dev.02248

Cited by 141 publications

(182 citation statements)

References 51 publications

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“…Experimental abrogation of Shh signaling in zebrafish, chick, and mouse results in loss of genetic fate determinants and cell identity in prethalamus and thalamus (Kiecker and Lumsden, 2004;Scholpp et al, 2006;Vue et al, 2009). Furthermore, ectopic activation of the Shh pathway by misexpression of a constitutively active Shh effector mutant (SmoM2) induces the expression of thalamic markers such as Gbx2, Ngn2, Olig2, and Olig3 in the mouse pretectum (Vue et al, 2009).…”

Section: Patterning Of Developing Thalamus and Hypothalamus By Secretmentioning

confidence: 99%

Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation

et al. 2010

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The embryonic diencephalon gives rise to the vertebrate thalamus and hypothalamus, which play essential roles in sensory information processing and control of physiological homeostasis and behavior, respectively. In this review, we present new steps toward characterizing the molecular pathways that control development of these structures, based on findings in a variety of model organisms. We highlight advances in understanding how early regional patterning is orchestrated through the action of secreted signaling molecules such as Sonic hedgehog and fibroblast growth factors. We address the role of individual transcription factors in control of the regional identity and neural differentiation within the developing diencephalon, emphasizing the contribution of recent large-scale gene expression studies in providing an extensive catalog of candidate regulators of hypothalamic neural cell fate specification. Finally, we evaluate the molecular mechanisms involved in the experience-dependent development of both thalamo-cortical and hypothalamic neural circuitry. IntroductionThe developing vertebrate forebrain consists of two major parts: the telencephalon-which gives rise to cerebral cortex, striatum, amygdala, and associated structures-and the diencephalon. The diencephalon gives rise to two essential brain regions, the thalamus and hypothalamus (Fig. 1 A). Though both structures are derived from a common region of the anterior neural tube, they serve very different physiological functions. The thalamus acts as a central integrator of sensory information, receiving afferents from receptors of all sensory modalities save olfaction, and serves as the sole path by which integrated sensory information reaches the cerebral cortex and gives rise to conscious perception. The hypothalamus, on the other hand, serves a more diverse range of functions. It is a central regulator of critical homeostatic physiological processes, including temperature regulation, food intake,

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Section: Patterning Of Developing Thalamus and Hypothalamus By Secretmentioning

confidence: 99%

Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation

et al. 2010

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“…In the diencephalic neuroepithelium, Shh shows an intriguing and dynamic pattern of expression with domains in the caudal-dorsal diencephalon [zona limitans interthalamica (ZLI)] and the rostral-ventral diencephalon (hypothalamic domain), which seem strategically situated to influence the formation of the DTJ. In the caudal diencephalon, neural Shh from the ZLI specifies the prethalamus (PTh) (Hashimoto-Torii et al, 2003;Kiecker and Lumsden, 2004;Vieira et al, 2005;Hirata et al, 2006;Scholpp et al, 2006;Guinazu et al, 2007) and promotes growth and differentiation of specific subdivisions of the thalamus (Szabó et al, 2009). The role of neural Shh in the rostral diencephalon (hypothalamus) and DTJ, however, is only starting to be analyzed.…”

Section: Introductionmentioning

confidence: 99%

Role of NeuroepithelialSonic hedgehogin Hypothalamic Patterning

et al. 2009

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The hypothalamus is a region of the diencephalon with particularly complex patterning. Sonic hedgehog (Shh), encoding a protein with key developmental roles, shows a peculiar and dynamic diencephalic expression pattern. Here, we use transgenic strategies and in vitro experiments to test the hypothesis that Shh expressed in the diencephalic neuroepithelium (neural Shh) coordinates tissue growth and patterning in the hypothalamus. Our results show that neural Shh coordinates anteroposterior and dorsoventral patterning in the hypothalamus and in the diencephalon-telencephalon junction. Neural Shh also coordinates mediolateral hypothalamic patterning, since it is necessary for the lateral hypothalamus to attain proper size and is required for the specification of hypocretin/orexin cells. Finally, neural Shh is necessary to maintain expression of differentiation markers including survival factor Foxb1.

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“…The zona limitans intrathalamica (ZLI) is a central boundary between the prethalamus and the thalamus that expresses sonic hedgehog (Shh), regulating both ventrodorsal and anteroposterior regionalization of the diencephalic neuroepithelium (Larsen et al, 2001;Kiecker and Lumsden, 2004;Zeltser, 2005;Scholpp et al, 2006;Vieira and Martinez, 2006;Szabó et al, 2009;Vue et al, 2009). In addition to Shh, other morphogenetic signals provided by the roof plate mediate patterning activity in the diencephalon, including Wnts (Yamaguchi, 2001;Braun et al, 2003;Zhou et al, 2004;Lavado et al, 2008) and Bmps (Furuta et al, 1997;Lim et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Development of the Thalamic Motor Learning Area Is Regulated by Fgf8 Expression

Martínez-Ferre¹,

Martı́nez²

2009

J. Neurosci.

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Habenular nuclei play a key role in the control of motor and cognitive behavior, processing emotion, motivation, and reward values in the brain. Thus, analysis of the molecular and cellular mechanisms underlying the development and evolution of this region will contribute to a better understanding of brain function. The Fgf8 gene is expressed in the dorsal midline of the diencephalon, close to the area in which the habenular region will develop. Given that Fgf8 is an important morphogenetic signal, we decided to investigate the role of Fgf8 signaling in diencephalic development. To this end, we analyzed the effects of altered Fgf8 expression in the mouse embryo, using molecular and cellular markers. Decreasing Fgf8 activity in the diencephalon was found to be associated with dosage-dependent alterations in the epithalamus: the habenular region and pineal gland are reduced or lacking in Fgf8 hypomorphic mice. Actually, our findings indicate that Fgf8 may be the master gene for these diencephalic domains, acting as an inductive and morphogenetic regulator. Therefore, the emergence of the habenular region in vertebrates could be understood in terms of a phylogenetic territorial addition caused by de novo expression of Fgf8 in the diencephalic alar plate. This region specializes to permit the development of adaptive control of the motor function in the vertebrate brain.

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Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon

Cited by 141 publications

References 51 publications

Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation

Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation

Role of NeuroepithelialSonic hedgehogin Hypothalamic Patterning

The Development of the Thalamic Motor Learning Area Is Regulated by Fgf8 Expression

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