Helical tomotherapy for total lymphoid irradiation

McCutchen, Kathryn W.; Watkins, John M.; Eberts, Paul T.; Terwilliger, Lacy E.; Ashenafi, M; Jenrette, Joseph M.

doi:10.1007/s11604-008-0281-4

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…McCutchen et al reported a single institution's experience of TLI performed by helical tomotherapy in an adult patient with late-onset cardiac transplant rejection (22). The prescribed dose was 8 Gy to 95% of PTV, in 10 twiceweekly fractions.…”

Section: Discussionmentioning

confidence: 99%

A single institution experience of total lymphoid irradiation using helical tomotherapy as part of the conditioning regimen of transplantation for severe aplastic anemia patients

Lee¹,

Wu²,

Wang³

et al. 2020

Ther Radiol Oncol

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Background: Total lymphoid irradiation (TLI) plays a role in the conditioning of hematopoietic stem cell transplantation (HSCT) from non-sibling donors for severe aplastic anemia (SAA) patients. For the past decades, an anterior-posterior opposed technique has been used to deliver TLI. We present our singleinstitution experience of helical tomotherapy TLI.Methods: From October 2014 to February 2019, three consecutive patients of SAA who underwent tomotherapy TLI for pre-transplantation conditioning were enlisted. We retrospectively analyzed the survival, engraftment outcome, and toxicities of these patients and created a conventional TLI plan with anterior-posterior opposed fields for each patient to compare the dosimetry difference between helical tomotherapy and the conventional technique.Results: Among all three patients, the engraftment rate was 100%. The 18-month overall survival and event-free survival were both 66.7% among the 3 patients (2 underwent unrelated donor transplantation and 1 underwent haplo-identical related donor transplantation), and 100% for the patients who received transplantation from matched-or mismatched-unrelated donors. No patient experienced acute grade 3 or worse graft-versus-host disease (GVHD), and none of the three patients suffered from late GVHD. No significant acute or late adverse events of radiation were observed. Tomotherapy-based TLI provides better target volume coverage with an average 10% higher coverage along with greater sparing of normal tissues.The total body volume exposed to 5 Gy was an average 35% lower in the tomotherapy-based TLI.Conclusions: TLI with non-ablative conditioning regimen provided excellent engraftment and an acceptable survival in the SAA patients who underwent non-sibling donor HSCT.

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Section: Discussionmentioning

confidence: 99%

A single institution experience of total lymphoid irradiation using helical tomotherapy as part of the conditioning regimen of transplantation for severe aplastic anemia patients

Lee¹,

Wu²,

Wang³

et al. 2020

Ther Radiol Oncol

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“…However, in this setting, more sophisticated RT techniques such as IMRT, IGRT, and especially helical-slit IMRT (HT) and cone-beam IMRT (RapidArc and VMAT) [ 30 ] might become appropriate alternatives for either definitive or palliative treatment for suitable patients based on compatible pulmonary toxicity criteria. Helical tomotherapy is a promising method, and achieves a better dose conformity in several tumor sites including MPM [ 31 - 33 ]. In their recent study, Sterzing et al compared step-and-shoot IMRT with HT [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of CT and integrated PET-CT based radiation therapy planning in patients with malignant pleural mesothelioma

et al. 2009

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This study demonstrated the usefulness of PET-CT-based target volume delineation in patients with MPM. Co-registration of PET and CT information reduces the likelihood of geographic misses, and additionally, significant reductions observed in target volumes may potentially allow escalation of RT dose beyond conventional limits potential clinical benefits in tumor control rates, which needs to be tested in future studies.

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“…Moreover, TOMO might provide safer and more accurate RT profile for selected HL patients with bulky residual disease. Last but not least, according to preliminary results TOMO might be administered for total lymphoid irradiation as the preparation for allogeneic bone marrow transplantation or as an alternative therapy for chronic graft-versus-host disease [ 50 ].…”

Section: Radiotherapy Techniques and Novel Methodsmentioning

confidence: 99%

The Role of Radiotherapy in Hodgkin’s Lymphoma: What Has Been Achieved during the Last 50 Years?

Witkowska

Majchrzak

Smolewski

2015

BioMed Research International

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Currently, Hodgkin's lymphoma (HL) has an excellent clinical outcome, with overall survival of approximately 90% in early stages of the disease. Based on young age of the majority of patients at the time of diagnosis and their long survival time, increased attention has been focused on long-term toxicity of therapy. While novel, directly targeting antitumor agents, with an excellent safety profile, have been developed for HL treatment, the role of radiotherapy is still debated. Radiotherapy may induce cardiovascular disease and impairment of thyroid or pulmonary function and, most importantly, may lead to development of secondary cancers. As a consequence, the current radiation therapy planning paradigm is mainly focused on a reduction of field size. As it was investigated in clinical trials regional therapy is as effective as extended field radiotherapy, but less toxic. Although chemotherapy is the mainstay of HL treatment, consolidative involved field radiation therapy is still considered to be the standard of care in both early and advanced stages. Recently, further field reduction has been investigated to further decrease the late radiation-induced toxicity. In this paper we describe the role and safety profile of radiotherapy in the past and present and hope for the novel techniques in the future.

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Helical tomotherapy for total lymphoid irradiation

Cited by 11 publications

References 14 publications

A single institution experience of total lymphoid irradiation using helical tomotherapy as part of the conditioning regimen of transplantation for severe aplastic anemia patients

A single institution experience of total lymphoid irradiation using helical tomotherapy as part of the conditioning regimen of transplantation for severe aplastic anemia patients

Comparison of CT and integrated PET-CT based radiation therapy planning in patients with malignant pleural mesothelioma

The Role of Radiotherapy in Hodgkin’s Lymphoma: What Has Been Achieved during the Last 50 Years?

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