Helicobacter pylori and gastric carcinoma: Serum antibody prevalence in populations with contrasting cancer risks

Correa, Pelayo; Fox, James G.; Fontham, Elizabeth; Ruiz, Bernardo; Lin, Youping; Zavala, Diego; Taylor, Nancy S.; Mackinley, Dawn; Lima, Eduardo de; Portilla, Humberto; Zarama, Guillermo

doi:10.1002/1097-0142(19901215)66:12<2569::aid-cncr2820661220>3.0.co;2-i

Cited by 339 publications

(138 citation statements)

References 6 publications

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“…A human model of gastric carcinogenesis proposed by Correa (1988) (Correa et al, 1990b). This IM incidence is significantly higher than that in German patients, in whom we found only 28% in H. pylori-infected subjects, and only 5% in uninfected subjects (Bayerdorffer et al, 1992).…”

Section: Discussioncontrasting

confidence: 40%

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Miehlke

Hackelsberger²,

Meining³

et al. 1998

Br J Cancer

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Summary In 50 Helicobacterpylori-infected gastric carcinoma patients the corpus gastritis was significantly higher than in matched H. pyloripositive control subjects (P < 0.01). Atrophy and intestinal metaplasia (IM) occurred significantly more often in the antrum of carcinoma patients (P < 0.01). The odds ratio for gastric carcinoma was 8.85 for high-grade corpus gastritis and 8.04 when atrophy in the antrum was present.

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Section: Discussioncontrasting

confidence: 40%

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Miehlke

Hackelsberger²,

Meining³

et al. 1998

Br J Cancer

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“…Prevalence of infection was not significantly different between regions (P ϭ 0.7001; 76% in Andes, 70% in Caracas), in contrast with reports showing a higher prevalence of H. pylori infection in populations with high gastric cancer risk. 13 Prevalence of infection was lower in private than in public hospitals (46 versus 72%, respectively). These hospitals serve different socioeconomic classes.…”

mentioning

confidence: 99%

Short report: socioeconomic and seasonal variations of Helicobacter pylori infection in patients in Venezuela.

Domínguez-Bello¹,

Beker²,

Guelrud³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. Infection by Helicobacter pylori is recognized as a risk factor for gastric cancer and peptic ulcer disease. Venezuela has regions with different gastric cancer risks; the Andean region has the highest gastric cancer mortality in the country. We performed a cross-sectional study on 357 patients who underwent endoscopy attending 2 private (n ϭ 76) and one public hospital in Caracas, Venezuela (n ϭ 215), and one public hospital in the Andes (n ϭ 66) to determine H. pylori infection (by a rapid biopsy urease test and histology). The proportion of infected patients in Caracas was significantly higher in public hospitals (72%) than in private hospitals (46%; P ϭ 0.00001), and there was no significant variation the Andes and Caracas (P ϭ 0.7001). When analyzing the data from the public hospital in Caracas, we found that the frequency of infected patients was significantly higher during the rain (96%) than during the dry months (70%, P ϭ 0.00000001). Differences in prevalence of infection in symptomatic patients was not related to the risk of gastric cancer but to socioeconomic differences. Rain-dependent factors that may be exacerbating the clinical activity of nonulcer dyspepsia in people infected with H. pylori deserve further study.Although most infected people remain asymptomatic, infection by Helicobacter pylori is recognized as a risk factor for gastric cancer, chronic gastritis, and peptic ulcer disease. 1 The outcome of peptic ulceration or gastric adenocarcinoma shows geographical variations. There are duodenal ulcer clusters in Scotland, Africa, Ethiopia, southern India, southern China, and eastern Australia. 2-4 Japan has a high incidence of gastric cancer, 5 with other clusters in northern China, 6 northern Italy, 7 southern Mexico, 8 and the Andean region. 9 Cancer is the first cause of mortality in the Venezuelan Andean states. As many as 4.1% of registered deaths were caused by gastric malignant tumors, compared with 1.4% in the Central states. 10 Because H. pylori infection plays a role in the etiology of gastric cancer, we hypothesized that prevalence of H. pylori in symptomatic patients in the Andes may be higher than in Caracas, Venezuela.We studied 357 patients who were referred to endoscopy who attended one public hospital in the Andean city of San Cristóbal (66 patients) and 3 hospitals in Caracas. Caracas hospitals comprised a single public hospital (215 patients) and 2 private hospitals (76 patients). Patients (or the legal representative) voluntarily signed a consent of participation. Patients referred to endoscopy who had not received antibiotics, anti-inflammatory steroids, H2 antihistaminics, or proton pump inhibitors in 30 days before endoscopy, were enrolled in the study. Helicobacter pylori infection was determined in 2 antrum gastric specimens from each patient. One was introduced in a rapid urease test 11 and the other was fixed in formaldehyde for the histology study after staining with hematoxylin and eosin. Patients were considered infected if one or both tests were positi...

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“…The presence of the bacterium has however been causally associated with type B gastritis and is a contributing factor in peptic ulcer disease [4]. It has also been implicated as a contributory factor in certain gastric carcinomas [5,6].…”

Section: Introductionmentioning

confidence: 98%

Molecular typing ofHelicobacter pyloriisolates from asymptomatic, ulcer and gastritis patients by urease gene polymorphism

et al. 1994

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SUMMARYThe gastric-adapted bacterium Helicobacter pylori plays an important role in gastritis and ulcer disease, but no phenotypic typing scheme presently exists for this organism. With a view to the development of genotypic typing, we have compared isolates of H. pytori from gastritis or ulcer patients with those from subjects exhibiting no disease. Variation was analysed at the urease genes, ureA and ureCD, by employing PCR-generated probes in genomic Southern blot hybridizations. Whilst ureA restriction fragments provided a fourfold subgrouping of strains, ureCD fragments were considerably more discriminatory. Twenty-four combined ureACD profiles were generated with Hind III, subdividing the 64 strains into 11 types and 13 single profiles. The most prevalent profile (UI) was found in 33 % of strains, almost all from gastritis or ulcer patients. On the other hand strains isolated from asymptomatic individuals had the most diverse ureACD profiles. A key finding from this set of isolates was that strains of H. pylori associated with general gastroduodenal disease were genetically more homogeneous than strains carried by people without disease symptoms. INTRODUCTIONThe Gram-negative bacterium Helicobacter pylori was first isolated in 1982 by Warren and Marshall [1]. Endoscopic and seroprevalence analyses indicate that this organism has a worldwide distribution, and is frequently isolated from asymptomatic persons [2]. By the age of 60 years, 40-60% of adult humans in developed countries show evidence of H. pylori infection without necessarily showing signs of disease [3]. The presence of the bacterium has however been causally associated with type B gastritis and is a contributing factor in peptic

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Helicobacter pylori and gastric carcinoma: Serum antibody prevalence in populations with contrasting cancer risks

Cited by 339 publications

References 6 publications

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Short report: socioeconomic and seasonal variations of Helicobacter pylori infection in patients in Venezuela.

Molecular typing ofHelicobacter pyloriisolates from asymptomatic, ulcer and gastritis patients by urease gene polymorphism

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