Helicobacter pylori and histopathological findings in patients with dyspepsia

Türkay, Cansel; Erbayrak, Mustafa; Bavbek, Nükhet; Yenıdünya, Sibel; Eraslan, Elife; Kasapoğlu, Benan

doi:10.4318/tjg.2011.0179

Cited by 9 publications

(7 citation statements)

References 31 publications

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“…Instead, activity and chronic inflammation in the antrum, as well as in the corpus significantly improved in the responders, but not in the non-responders, suggesting that H. pylori -induced inflammation mediates dyspeptic symptoms, but not atrophy itself. Our results could be supported by the report that the activity and inflammation increased with increase of H. pylori intensity in patients with dyspepsia 46. In addition, H. pylori -positive FD patients with 'antrum predominant' chronic gastritis showed symptom improvement at 1 year after the successful eradication 3.…”

Section: Discussionsupporting

confidence: 89%

Effect of Eradication on Functional Dyspepsia

Kim¹,

Park²,

Kim³

et al. 2013

J Neurogastroenterol Motil

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Background/AimsThis study evaluated the effect of Helicobacter pylori eradication on functional dyspepsia (FD), and the relationship between the changes of histological gastritis and FD symptom responses.MethodsA total of 213 FD patients diagnosed by Rome III criteria were consecutively enrolled. H. pylori tests and gastritis grade by the Sydney system were performed before and 1 year after the proton pump based-eradication therapy for 7 days. Serum levels of pepsinogen, and genetic polymorphisms IL-6, IL-8 and IL-10 were investigated.ResultsTotal of 91 patients completed the 1 year follow-up. When the response rate of dyspepsia was compared at 1 year between the non-eradicated group (n = 24) and eradicated group (n = 67), each group showed complete response of 62.5% and 62.7%; satisfactory response (≥ 50%) of 0.0% and 19.4%; partial response (< 50%) of 12.5% and 11.9%; and refractory response of 25.0% and 6.0%, respectively (P = 0.015). In addition, the responder group (complete + satisfactory response) at 1 year showed improvement of activity and chronic inflammation in both the antrum and corpus (all P < 0.001). Multivariate analysis showed that H. pylori eradication (OR, 5.81; 95% CI, 1.07-31.59) and symptom improvement at 3 month (OR, 28.90; 95% CI, 5.29-157.82) were associated with the improvement of dyspepsia at 1 year. Among the successfully eradicated FD patients (n = 67), male (P = 0.013) and higher initial BMI (P = 0.016) were associated with the improvement of dyspepsia at 1 year.ConclusionsH. pylori eradication improved FD symptoms, as well as gastritis at 1 year, suggesting that inflammation mediates FD.

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Section: Discussionsupporting

confidence: 89%

Effect of Eradication on Functional Dyspepsia

Kim¹,

Park²,

Kim³

et al. 2013

J Neurogastroenterol Motil

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“…As in our study, Basir, et al also found a significant relationship between H. pylori colonization intensity and chronic gastritis activity [20]. In a study performed by means of Histopathological examination of endoscopic biopsy specimens of 461 patients, Türkay, et al reported that as the intensity of H. pylori increased, the intensity of inflammation increased, too [21]. In a study conducted by Alagöz, et al a significant correlation was observed between H. pylori severity and lymphoplasmacytic cell infiltration and inflammation activation [22].…”

Section: Methodssupporting

confidence: 84%

The Relation between Helicobacter Pylori Density and Gastritis Severity

Sayin¹

2019

Int Arch Intern Med

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Background/Aims: Helicobacter pylori affects many individuals in developing countries. Inflammation caused by helicobacter pylori differs depending on the virulence factors, density and host tissue response of the bacteria. This study is intended to investigate the relation between density of helicobacter pylori colonization in gastric mucosa in biopsy specimens and gastric mucosal inflammation severity. Materials and methods: Our study included 685 patients who applied to the hospital with dyspeptic complaints and had gastroscopy between the dates of January the 1 st 2017 and January the 1 st 2018. Histopathologic results of endoscopic biopsy specimens of these patients were retrospectively screened. Inflammatory severity and helicobacter pylori intensity were assessed by Sydney scoring. Results: 68.6% of the patients were infected with Helicobacter pylori. As the intensity of inflammation increased, the intensity of Helicobacter pylori increased as well. The relation between the intensity of Helicobacter pylori and the severity of inflammation was statistically significant (p < 0.001). Conclusion: Helicobacter pylori infection increases gastric inflammation.

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“…In a previous study, the ratio of chronic gastritis and glandular metaplasia had been found in cirrhotic patients as follows: 15.6% of patients of Child-Pugh A, 70% of Child-Pugh B, and 100% of Child-Pugh C [23]. In a Turkish study on patients with dyspepsia, atrophy was found in only 5.5% of cases [24]. In our study, the incidence of atrophy and intestinal metaplasia was approximately 13%.…”

Section: Discussionsupporting

confidence: 55%

Helicobacter pylori rate and histopathological evaluation in HBeAg-negative chronic hepatitis B virus infection

Özdoğan¹,

Yaraş²

2019

Arch Med Sci Civil Dis

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Introduction: Studies of Helicobacter pylori (HP) in liver diseases and hepatitis B virus (HBV) infection have been increasingly discussed. Most studies investigating the relationship between HP and HBV have been conducted in patients with cirrhosis and hepatocellular carcinoma (HCC) and usually involving noninvasive tests. The HP frequency in these patients was higher than in healthy controls. No histopathological evaluation was performed in these studies. We investigated the incidence of HP in HBeAg-negative chronic HBV infection (previously termed "inactive carrier") by using invasive gastric biopsies and carried out histopathological evaluation. Material and methods: We included 90 treatment-naive inactive hepatitis-B carriers as patients. The control group comprised 107 healthy subjects. Biopsies were obtained from the antrum and corpus and were evaluated histopathologically using the Sydney system of classification for gastritis. Results: The rate of HP in inactive hepatitis-B carriers was significantly higher than the control group (75.6% vs. 53.3%, respectively; p = 0.001). There was no difference in incidence of atrophy, intestinal metaplasia, activity, or inflammation (p > 0.05). Peptic ulcer was detected in 11 (12.2%) patients in the HBV group and in 7 (6.5%) patients in the control group (p = 0.360). The incidence of HP was higher in patients with HBV DNA ≥ 2000 IU/ml than in patients with HBV DNA < 2000 IU/ml, but this difference was not statistically significant (85% vs. 68%, respectively; p = 0.062). Conclusions: Although the HP rate in inactive hepatitis-B carriers was higher than the control group, there were no intergroup differences with respect to atrophy, intestinal metaplasia, activity, inflammation, and peptic ulcer frequency.

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Helicobacter pylori and histopathological findings in patients with dyspepsia

Cited by 9 publications

References 31 publications

Effect of Eradication on Functional Dyspepsia

Effect of Eradication on Functional Dyspepsia

The Relation between Helicobacter Pylori Density and Gastritis Severity

Helicobacter pylori rate and histopathological evaluation in HBeAg-negative chronic hepatitis B virus infection

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