Helicobacter pylori-associated diseases

Abstract

Since the initial report 20 years ago by Marshall and Warren of an unidentified curved bacillus located on the gastric epithelium of patients with chronic active gastritis, the discovery of Helicobacter pylori and its association with a number of gastrointestinal diseases has revolutionized the field of gastroenterology. Although the association of H. pylori infection with peptic ulcer disease, chronic gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric adenocarcinoma has been well documented over the past two decades, other areas remain less clear, including the role of H. pylori in gastropathy associated with nonsteroidal anti-inflammatory drugs, gastroesophageal reflux disease, and both uninvestigated and nonulcer dyspepsia. Although these areas still remain somewhat controversial, recent reports further clarify the role of H. pylori in these conditions. A review of the recent literature regarding H. pylori-associated diseases is presented along with recommendations for diagnosis and treatment of H. pylori infection.

Expression of CagL from Helicobacter pylori and Preliminary Study of its Biological Function

“…Helicobacter pylori (H. pylori) is a gram-negative, spiralshaped, microaerophilic bacterium that colonizes the human gastric mucosa and is recognized as the causative agent of chronic active gastritis, gastric and duodenal ulcers or lymphoma of the MALT (mucosa-associated lymphoid tissue) system, and is a risk factor for the development of adenocarcinoma [1][2][3]. This microorganism has been categorized as class I carcinogen by the World Health Organization [1].…”

Lack of humoral response against Helicobacter pylori peptides homologous to human ZnT8 in Hashimoto’s thyroiditis patients

“…The overall prevalence of HP infection is higher in developing countries compared to developed nations [8].…”

Erratum: The challenge of emerging and re-emerging infectious diseases

“…Examples include the associations of hepatitis B and C with chronic liver damage and hepatocellular carcinoma, of certain genotypes of human papillomaviruses with cancer of the uterine cervix, of Epstein-Barr virus with Burkitt's lymphoma (largely in Africa) and nasopharyngeal carcinoma (in China), of human herpesvirus 8 with Kaposi sarcoma, and of Helicobacter pylori with gastric ulcers and gastric cancer [50][51][52] . Some data even suggest infectious aetiologies for cardiovascular disease and diabetes mellitus 53 , major causes of death and disability worldwide.…”