Helicobacter pylori: bridging the credibility gap.

McKinlay, Alastair; Upadhyay, Rajesh Kumar; Gemmell, CG; Russell, Robin

doi:10.1136/gut.31.8.940

Cited by 35 publications

(3 citation statements)

References 56 publications

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“…1 Iron deficiency anemia secondary to inadequate dietary iron intake 280. 8 Other specified iron deficiency anemias 280.9…”

Section: Author Contributionsmentioning

confidence: 99%

“…Dyspepsia is defined as “chronic or recurrent pain or discomfort centered in the upper abdomen” and is among the most common reasons for visits to primary care providers or referrals to gastroenterology specialists . Dyspepsia may be a sign of acute or chronic Helicobacter pylori infection, which was shown to be an etiology for dyspepsia after its first identification from stomach biopsy cultures in the early 1980s . Dyspepsia is also a cause of concern for patients over the age of 50 because of the increased incidence of gastric malignancy .…”

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confidence: 99%

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The Epidemiology, Diagnosis, and Cost of Dyspepsia and Helicobater pylori Gastritis: A Case–Control Analysis in the Southwestern United States

et al. 2012

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BackgroundDyspepsia is among the most common complaints evaluated by gastroenterologists, but there are few studies examining its current epidemiology, evaluation, and costs. We examined these issues in a large managed care system in the Southwestern United States.MethodsWe conducted a retrospective case–control analysis of adults with incident dyspepsia or a Helicobacter pylori-related condition in years 2006 through 2010 using utilization data. Medical record abstraction of 400 cases was conducted to obtain additional clinical information.ResultsA total of 6989 cases met all inclusion and exclusion criteria. Women had a substantially higher risk of dyspepsia than men (14 per 1000 per year vs 10 per 1000; p < .001), and the incidence of dyspepsia increased with age such that persons in their seventh decade had almost twice the risk of those aged 18–29. Hispanic persons had a significantly higher risk of dyspepsia and positive H. pylori testing. Dyspepsia cases had a higher prevalence of other chronic comorbidities than their matched controls. Dyspepsia patients had healthcare costs 54% higher than controls even before the diagnosis was made, and costs in the initial diagnostic period were $483 greater per person, but subsequent costs were not greatly affected. Among those aged 55 and younger, the “test and treat” approach was used in 53% and another 18% had an initial esophagogastroduodenoscopy, as compared to 47 and 27%, respectively, among those over the age of 55.ConclusionsWomen and older adults have a higher incidence of dyspepsia than previously appreciated, and Hispanics in this region also have a higher risk. Current guidelines for dyspepsia evaluation are only loosely followed.

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“…1 Iron deficiency anemia secondary to inadequate dietary iron intake 280. 8 Other specified iron deficiency anemias 280.9…”

Section: Author Contributionsmentioning

confidence: 99%

mentioning

confidence: 99%

The Epidemiology, Diagnosis, and Cost of Dyspepsia and Helicobater pylori Gastritis: A Case–Control Analysis in the Southwestern United States

et al. 2012

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“…Δεν επηρεάζεται η τοπική παραγωγή προσταγλανδινών PGE2, PGI2, ΤΧΒ2, ενώ έχει βρεθεί, μη σημαντική στατιστικά μείωση της προσταγλανδίνης 6-Keto-F2a. Παρά τα ανωτέρω, η συνθετική προσταγλανδίνη μισοπροστόλη μειώνει τη φλεγμονώδη αντίδραση που προκαλεί το Η. pylori (258,259).…”

Section: λειτουργικές και βιοχημικές μεταβολές του γαστρικού βλεννογόνου από η Pyloriunclassified

Διάγνωση και παρακολούθηση ασθενών με γαστρίτιδα και Helicobacter (Campylobacter) pylori

Σαλαμέτης¹

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Efficacy of Bismuth‐Based Triple Therapy in Children With Abdominal Pain and Helicobacter pylori Gastritis

Shamaly,

Berkowitz,

Rosenthal

et al. 2000

J. pediatr. gastroenterol. nutr.

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Background:To evaluate the effect of a therapeutic regimen of 7 days versus 14 days on the clinical manifestations of Helicobacter pylori gastritis in children.Methods:Ninety children (age 2–19 years) who had abdominal pain and/or recurrent vomiting were determined to have H. pylori gastritis by endoscopy, histology, and a Giemsa stain positive for H. pylori. The patients were randomized to receive amoxicillin, metronidazole, and bismuth subcitrate for 7 days (group A; 45 children) or 14 days (group B; 45 children) and were observed clinically for 19 ± 11.5 months. Resolution of all abdominal and gastrointestinal symptoms was considered a good response.Results:A good response was obtained in 36 (80%) children from group A, and in 37 (82%) from group B. A recurrence of symptoms occurred in four (11%) of the responders from group A, and in six (15.2%) from group B.Conclusions:A 7‐day course of bismuth‐based triple therapy for H. pylori gastritis in children appears to be clinically as effective as a 14‐day regimen. The feasibility of a shorter therapeutic regimen may enhance patient compliance and provide a better chance of clinical benefit.

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Helicobacter pylori: bridging the credibility gap.

Cited by 35 publications

References 56 publications

The Epidemiology, Diagnosis, and Cost of Dyspepsia and Helicobater pylori Gastritis: A Case–Control Analysis in the Southwestern United States

The Epidemiology, Diagnosis, and Cost of Dyspepsia and Helicobater pylori Gastritis: A Case–Control Analysis in the Southwestern United States

Διάγνωση και παρακολούθηση ασθενών με γαστρίτιδα και Helicobacter (Campylobacter) pylori

Efficacy of Bismuth‐Based Triple Therapy in Children With Abdominal Pain and Helicobacter pylori Gastritis

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