Helicobacter pylori cagA and vacA Genotypes and their Relationships to Peptic Ulcer Disease and Non-Ulcer Dyspepsia

Nahaei, Mohammad Reza; Sharifi, Yaeghob; Akhi, Mohammad Taghi; Asgharzadeh, Mohammad; Nahaei, Mehrnaz; Fatahi, E

doi:10.3923/jm.2008.386.394

Cited by 7 publications

References 1 publication

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Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Keikha

Ali‐Hassanzadeh

2020

BMC Gastroenterol

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Background: Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genotypes and gastrointestinal disorders has attracted a lot of attention. In present study, we assessed the correlation between vacA genotypes (s1, s2, m1, m2, s1m1, s1m2, s2m1 and s2m2) and development to peptic ulcer in Iranian population. Methods: In our study, first, 24 original articles containing of information of 3328 patients were evaluated. Statistical analysis was done by Comprehensive Meta-Analysis version 2.0 software (Biostat, Englewood, NJ, USA). In this regards, we used from fixed-effects model for analysis of data with low heterogeneity, while for analysis of data with high heterogeneity (I 2 statistic index > 25%, Cochrane Q statistic p value < 0.05), random-effects model was used.

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Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Keikha

Ali‐Hassanzadeh

2020

BMC Gastroenterol

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Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive disorders from 5 Azar Hospital in Gorgan city in 2017.

Heidari

Kaboosi

Jamali

et al. 2019

Iran J Med Microbiol

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Article Subject:Medical Microbiology Background and Aims: Helicobacter pylori is the main cause of various gastroduodenal diseases. It is estimated that app roximately, more than half of the adult population in developed countries and 90% of people in developing countries infected with H. pylori. H. pylori infection may be related to Genetic of virulence factors and environmental factors. The aim of this study was to assess of frequency cagA and vacA genes of H. pylori isolated from patients with Gastrointestinal Disorders.Materials and Methods: This cross-sectional descriptive study carried out on 120 patients with gastrointestinal diseases in Gorgan city in 2017. (40 patients of gastric cancer, 40 patients of peptic ulcer, 40 patients of without cancer and ulcer). After genomic DNA extraction PCR was carried out using specific H.pylori primers.Results: Overall, 120 H.pylori strains were isolated. The frequency of cagA was %67.5 in gastric cancer, %60 in peptic ulcer and %45 in patiens without ulcer and gastric cancer. Also frequency of vacA gene was detected %55 in gastric cancer, %40 in peptic ulcer and %27.5 in patiens without ulcer and gastric cancer.Conclusion: Based on our findings it seems that the cag A and vac A genes were virulence among H. pylori isolated from studied patients. The frequency of cagA and vacA genes H. pylori were than in gastric cancer and peptic ulcer patients.

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Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

Sayehmiri

Kiani

Sayehmiri

et al. 2015

J Infect Dev Ctries

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The varieties of infections caused by Helicobacter pylori may be due to differences in bacterial genotypes and virulence factors as well as environmental and host-related factors. This study aimed to investigate the prevalence of cagA and vacA genes among H. pylori-infected patients in Iran and analyze their relevance to the disease status between two clinical groups via a meta-analysis method. Different databases including PubMed, ISI, Scopus, SID, Magiran, Science Direct, and Medlib were investigated, and 23 relevant articles from the period between 2001 and 2012 were finally analyzed. The relevant data obtained from these papers were analyzed by a randomeffects model. Data were analyzed using R software and STATA. The prevalence of cagA and vacA genes among H. pylori-infected patients was 70% (95% CI, 64-75) and 41% (95% CI, 24.3-57.7), respectively. The prevalence of duodenal ulcers, peptic ulcers, and gastritis among cagA+ individuals was 53% (95% CI, 20-86), 65% (95% CI, 34-97), and 71% (95% CI, 59-84), respectively. Odds ratio (OR) between cagA-positive compared with cagA-negative patients showed a 1.89 (95% CI, 1.38-2.57) risk of ulcers. In conclusion, the frequency of cagA gene among H. pylori strains is elevated in Iran and it seems to be more frequently associated with gastritis. Therefore, any information about cagA and vacA prevalence among different H. pylori-infected clinical groups in the country can help public health authorities to plan preventive policies to reduce the prevalence of diseases associated with H. pylori infection.

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Helicobacter pylori cagA and vacA Genotypes and their Relationships to Peptic Ulcer Disease and Non-Ulcer Dyspepsia

Cited by 7 publications

References 1 publication

Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive disorders from 5 Azar Hospital in Gorgan city in 2017.

Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

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