Helicobacter pylori in Children Who Are Prone to Upper Respiratory Tract Infections

Pitkäranta, Anne; Kolho, Kaija‐Leena; Rautelin, Hilpi

doi:10.1001/archotol.131.3.256

Cited by 26 publications

(19 citation statements)

References 17 publications

(22 reference statements)

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“…The negative results we have obtained by PNA-FISH and PCR-DEIA are also in accordance with previously published data using PCR and/or culture [14,15,[17][18][19][20]. The use of PCR for detection of H. pylori in adenotonsillar tissues has sporadically given positive results [21].…”

Section: Discussionsupporting

confidence: 91%

Helicobacter pylori colonization of the adenotonsillar tissue: Fact or fiction?

Vilarinho

Guimarães

Ferreira

et al. 2010

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionsupporting

confidence: 91%

Helicobacter pylori colonization of the adenotonsillar tissue: Fact or fiction?

Vilarinho

Guimarães

Ferreira

et al. 2010

International Journal of Pediatric Otorhinolaryngology

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“…Contrary to these studies, Yılmaz et al [21] did not find any positivity in tonsillar and adenoid tissue by the CLO test. Pitkaranta et al [22] investigated adenoid tissue and middle ear fluid by culture. They found negative results.…”

Section: Discussionmentioning

confidence: 99%

Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Aydın

Aydoğan

Taştan

et al. 2011

Indian J Otolaryngol Head Neck Surg

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To investigate whether there is any association between nasopharyngeal reflux and adenoid hypertrophy in children by using 24-h pH monitoring with dual probe and to determine whether Helicobacter pylori simply colonises in adenoid tissue or it is present there temporarily due to extraesophageal reflux. A prospective study at a tertiary referral center. Thirty-two patients who underwent adenoidectomy, aged ranged between 4 and 13 were included. All children with adenoid hypertrophy underwent 24-h pH monitoring with a dual probe. Proximal probe was placed in the nasopharynx. The presence of nasopharyngeal reflux and gastroesophageal reflux were investigated by 24-h pH monitoring. The presence of H. pylori was investigated in adenoidectomy samples by HP-fast test. Of the 32 patients who underwent adenoidectomy, 5 had nasopharyngeal reflux positivity while 27 patients did not show nasopharyngeal reflux positivity with pH monitorisation. Helicobacter pylori could not be detected in 5 nasopharyngeal reflux positive children while 3 of 27 nasopharyngeal reflux negative children showed H. pylori positivity, one of them in the mucosa and others in the core. This study demonstrated the high incidence of nasopharyngeal reflux and gastroesophageal reflux in adenoid hypertrophy and the possible colonisation of H. pylori in the adenoid tissue. This may change the assesment of children with adenotonsillar hypertrophy in near future. However, more placebo controlled and double blind studies and larger series are still needed to support this hypothesis.

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“…This enthusiasm was not confirmed in the conclusions of other publications, as the study of Antonelli et al [19], for example, who measured the total pepsinogen concentration in 26 acute otorrhea samples after ventilation tube placement and found pepsinogen in some cases, but at low concentrations, lower than normal serum levels. By other means, Pitkaranta et al [20] also did not find evidence of the association of MEE and GER. Analyzing the presence of Helicobacter pylori through serological tests to detect antigens and through adenoids and MEE cultures, they found only 20 % of the serological tests positive, and in none of the cases was there growth of the germ in adenoid or middle-ear cultures.…”

Section: Gastroesophageal Reflux (Ger)mentioning

confidence: 89%