Helicobacter pylori in gastroduodenal perforation

Dogra, Bharat Bhushan; Panchabhai, Sunil; Rejinthal, Santosh; Kalyan, Sai; Priyadarshi, Siddharth; Kandari, Ashwani

doi:10.4103/0975-2870.126331

Cited by 12 publications

(16 citation statements)

References 4 publications

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“…Males are more affected than females (M: F ratio was 4.14:1). This was similar with the findings of Dogra et al 5 In our study, the prevalence rate of H. pylori infection was 46.9%. This was comparable to the studies of Hussain et al in which the prevalence rate was 67%.…”

Section: Discussionsupporting

confidence: 83%

Prevalence of Helicobacter pylori in peptic ulcer perforation

2017

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Background: Helicobacter pylori have an important role in the pathogenesis of peptic ulcer disease. The aim of the present study was to observe the prevalence of H. pylori in peptic ulcer perforation cases and the rationale of H. pylori eradication therapy post operatively and to investigate factors associated with peptic ulcer.Methods: This cross-sectional study was conducted at the Department of general surgery, Government Medical College, Kottayam for a period 20 months from March 2012 to October 2013 after getting approval from institutional ethics committee. A total of 113 patients were participated in the study after meeting inclusion criteria. After getting written consent from the patients with perforated peptic ulcer, resuscitation and laparotomy was performed in the emergency department. H. pyloriinfection was confirmed by histopathological examination by Giemsa staining. Based on the histopathological report, the prevalence of H. pylori infection in the patients was assessed and was given appropriate H. pylori eradication regimen.Results: The mean age of presentation of the patients was 52.81±14.5 years. Male to female ratio was 4.14:1. Out of 113 cases, 67 cases (59.3%) had duodenal ulcer perforation while 46 cases (40.7%) had gastric ulcer perforation. Of them 53(46.9%) cases were positive H. pylori positive. No significant association was found between the incidence of H. pylori infection in peptic ulcers with smoking, hypertension, diet intake, NSAIDS intake. In our study association between H. pylori and diabetes mellitus (p=0.02) found to be significant which can be further investigated.Conclusion: According to our study the prevalence of H. pylori infection in perforated peptic ulcer disease is 47% which must be considered as significant. Hence all the patients undergoing laparotomy for peptic ulcer perforation should be investigated for H. pylori infection and if positive we must start the anti H. pylori regimen for them, which is more cost effective.

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Section: Discussionsupporting

confidence: 83%

Prevalence of Helicobacter pylori in peptic ulcer perforation

2017

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“…11 In study by Dogra et al, mean age was 49.2years. 8 In study by John et al, commonest age of presenatation is 45-60yrs with mean age of 52.81± 14.5yrs. 6 Tas et al, study showed a mean age of 51.7±20 yrs.…”

Section: Discussionmentioning

confidence: 96%

“…In study by Dogra et al, male to female ratio was 3:1. 8 The study by Surapaneni had a male female ratio of 9:1. 11 In study by John et al male to female ratio was 4.1:1.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Helicobacter pylori infection in patients with gastric ulcer perforation admitted in a tertiary care centre

Rashim

Vineed

2019

Int Surg J

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Background: Gastric ulcers are one of the most prevalent gastro intestinal diseases. Perforation of gastric ulcer is most common and dreaded complication of a gastric ulcer. Causes of gastric ulcer include Helicobacter Pylori, the NSAID, smoking and alcohol. Helicobacter Pylori infection is a curable cause of gastric ulcer. As prevalence of H. pylori differ in populations, prevalence of H. pylori in our population need to be assessed for determining treatment strategy for gastric ulcer.Methods: Cross sectional study conducted in patients operated for perforation peritonitis and diagnosed to have gastric ulcer perforation in a tertiary care centre. Full thickness biopsy was taken from gastric ulcer perforation edge during the surgery for perforation peritonitis. The biopsy was stained with Giemsa stain and looked for the presence of H. pylori.Results: Helicobacter pylori prevalence was 48.8% in our study. 8 females (out of 16) and 51 males (out of 105) had H. pylori positivity. 43 had history of smoking. Among them 20 were diagnosed to be having H. pylori positive. 26 persons had history of pan chewing. Among pan chewers 17 were H. pylori positive. Among 50 patients with history of alcoholism, 24 got H. pylori positivity. Among 40 patients with history of NSAIDs, 14 were positive for H. pylori.Conclusions: Prevalence of Helicobacter pylori in gastric ulcer perforation in present study is 48.8%. Helicobacter Pylori eradication should be added in treatment protocols for perforated gastric ulcers.

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“…Peptic ulcer disease was a common problem since dawn of human civilization.This disease was believed to be caused by stress, dietary factors, and increased gastric acid secretion till as late as 1983, when Warren and Marshall identified the correlation between Helicobacter pylori infection and peptic ulcer 1 .Near half of the world population is affected by H. Pylori. 2 More than 95% of patients suffering from duodenal ulcers and about 70-80% of patients with gastric ulcers are H. pylori positive 3 .…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and its correlates among the patients of peptic perforation and gastric carcinoma

Saha¹,

Bakshi²,

Mandal³

2020

Preprint

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Background: Presence of H. pylori infection was found associated with peptic perforation and gastric carcinoma. Present study tried to estimate the prevalence of H. pylori infection in those patients and to find out the correlates of H. pylori infection.Methods: After matching the inclusion and exclusion criteria, all cases of diagnosed peptic perforation and gastric carcinoma were taken for this prospective, single center, observational study.Results: Among the study population, gastric carcinoma was found in higher age group; whereas peptic perforation was found in lower age group; male and female ratio was 2:1 in both groups of patient. Laborer and housewives were mostly affected in both cases. Gastric carcinoma was more prevalent in urban residents, opposite was seen in peptic perforation. Most patients in two groups had no previous co-morbid condition. Use of NSAIDs was found in high frequency in both groups. Most of the patients were chronic alcoholic and chronic smoker, and most of them had history of taking spicy foods more than twice in a week.Conclusions: H. pylori infection was found in high frequency in both group of patients, and it was higher in peptic perforation. The study establishes the association of H. pylori with the gastric carcinoma and peptic perforation.

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Helicobacter pylori in gastroduodenal perforation

Cited by 12 publications

References 4 publications

Prevalence of Helicobacter pylori in peptic ulcer perforation

Prevalence of Helicobacter pylori in peptic ulcer perforation

Prevalence of Helicobacter pylori infection in patients with gastric ulcer perforation admitted in a tertiary care centre

Helicobacter pylori infection and its correlates among the patients of peptic perforation and gastric carcinoma

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