Helicobacter pylori Infection and Chronic Gastritis

Giacomo, Costantino De; Fiocca, Roberto; Villani, Laura; Lisato, Laura Camilla; Licardi, G; Diegoli, Nivaldo Murilo; Donadini, A.; Maggiore, Giuseppe

doi:10.1097/00005176-199010000-00005

Cited by 104 publications

(6 citation statements)

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“…Furthermore, the frequency of gastritis increases in correlation with age [5,14,21], in agreement with our results. The classical aspect of chronic active gastritis commonly observed in adults, characterized by prevalence of polynuclear neutrophils in the inflammatory infiltrate, is rarer in children [7,23,24], also in agreement with our study.…”

Section: Discussionsupporting

confidence: 92%

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

et al. 2008

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The aim of this study was to analyze the histological characteristics according to the updated Sydney classification (intensity of gastritis, degree of activity, gastric atrophy, intestinal metaplasia, and Helicobacter pylori) in symptomatic children referred for upper gastrointestinal endoscopy. A 4-year retrospective descriptive study was carried out in 619 children (282 females and 337 males), median age 3.75 years (15 days to 17.3 years) referred for endoscopy. Six gastric biopsies were done (three antrum and three corpus) for histological analysis (n = 4), direct examination and H. pylori culture (n = 2). H. pylori status was considered positive if at least two out of three tests were positive and negative if all three tests were negative. The results showed that only 66 children (10.66%) were H. pylori positive. Histological antral and corpus gastritis was detected in, respectively, 53.95% and 59.12% of all cases, most of them of mild grade 1. Antral and corpus activity was grade 1 in 18.57% and 20.03% of cases. H. pylori-positive versus H. pylori-negative children did differ in terms of moderate and marked histological gastritis and grade 2 or 3 activities. One girl had moderate gastric atrophy and another one moderate intestinal metaplasia, both being H. pylori negative. The findings indicate that primary antrum and corpus gastritis is 5.3 and 6.9 times, respectively, more frequent than H. pylori gastritis in French children, with usually mild histological gastritis and activity. Gastric atrophy and intestinal metaplasia are rare.

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Section: Discussionsupporting

confidence: 92%

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

et al. 2008

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“…Conversely, in children who remained H. pylori-positive, gastritis persisted. 11,21,22 In a study of Russian children with peptic ulcer disease, Shcherbakov et al (2001) allocated children to one of three treatment arms, with regimens consisting of two antibiotics (metronidazole and amoxicillin) and one of three PPIs (proprietary omeprazole, generic omeprazole or ranitidine). The authors reported that all three regimens led to rapid symptom relief during the first week; however, two children in the ranitidine treatment arm experienced ulcer relapses that resulted in the recurrence of epigastric pain, heartburn and nausea.…”

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confidence: 99%

“…Studies designed to investigate benefits of eliminating H. pylori on dyspeptic symptoms and recurrent abdominal pain should compare changes in symptom profiles before and after anti-H. pylori therapy in children with successful elimination of H. pylori to those with persistent infection, while controlling for potentially confounding factors that influence the persistence of symptoms. Abdominal pain and dyspeptic symptoms [21] 67 [14/21] 71 [15/21] † † epigastric pain [9] ND ND Periumbilical pain [7] ND ND Diffuse pain [5] ND ND † included 5 Swiss children and 24 non-Swiss children; † † Reported no statistical differences between those who eliminated the H. pylori infection and those who remained H. pylori-positive; ‡ proportion of children who were followed successfully; ND, no data in report; O, omeprazole; L, Lanzoprazole; R, ranitidine; RCT, randomized controlled trial; PPi, proton pump inhibitor; HP, H. pylori¬¬; A, amoxicillin; Am, ampicillin; B, bismuth subcitrate; C, clarithromycin; Cm, cimetidine; O, omeprazole; M, metronidazole; T, tetracycline; Tin, tinidazole; +, positive; -, negative.…”

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confidence: 99%

What do we know about benefits of H. pylori treatment in childhood?

2013

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“…In two recent studies from Italy and Brazil, gastric antral mucosa was described as micronodular in >50% of H. pylori-associated gastritis (11,13). We found such appearance in the minority (22%), with the majority either showing mild erythema or a normal endoscopic picture.…”

Section: Discussionmentioning

confidence: 40%

“…In adults, combined therapy with antibiotic drugs and bismuth salts has been shown to be effective in eradicating H. pylori and improving gastritis (22). In children, a combination of amoxycillin and tinidazole for 6 weeks have produced eradication of the organisms in 75% ( 23), and similar results were obtained with oral bismuth and ampicillin (13). Our results were disappointing, with only 42.9% clearing H. pylori after 6 weeks of treatment.…”

Section: Discussionmentioning

confidence: 50%

Helicobacter pylori‐Associated Gastritis in Kuwait

Radhakrishnan,

Nakib,

Kalaoui

et al. 1993

J. pediatr. gastroenterol. nutr.

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SummaryInformation is limited concerning the prevalence of Helicobacter pylori infection in asymptomatic children. Since January 1989, we have endoscoped 60 children for recurrent abdominal pain or for obtaining small‐intestinal biopsy (their ages were a mean of 6.6 (range 9 months‐13 years); there were 37 boys and 23 girls. Antral biopsies were obtained from all subjects and these were studied for the presence of gastritis and stained for H. pylori using modified Gram's stain. All biopsies were cultured for H. pylori. Children endoscoped for small‐intestinal biopsy (n = 18) were used for comparison. Of the 42 children who had abdominal pain, 24 snowed histological gastritis and 13 had H. pylori on microscopy (31% H. pylori associated gastritis). In the compared group, five showed histological gastritis, and all had H. pylori on microscopy (27.7%). Culture was positive in 15; sensitivity was 85.7%. Six children, three pairs of siblings, had H. pylori gastritis supporting environmental etiology. Two had coinfection with intestinal giardiasis. Seven children were treated with daily oral amoxycillin (50 mg/kg) and tinidazole (20 mg/kg) for 6 weeks. In 3 (42.3%) H. pylori colonization cleared with healing of gastritis and resolution of symptoms. These results indicate that H. pylori gastritis is equally prevalent in symptomatic and asymptomatic children (31 and 27.7%, respectively; p > 0.05) in our population. It seems that the combination of oral amoxycillin and tinidazole is a poor choice in the treatment of H. pylori associated gastritis in Kuwaiti children.

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Helicobacter pylori Infection and Chronic Gastritis

Cited by 104 publications

References 0 publications

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

What do we know about benefits of H. pylori treatment in childhood?

Helicobacter pylori‐Associated Gastritis in Kuwait

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