Helicobacter pylori infection and gastric neoplasia: correlations with histological gastritis and tumor histology

Komoto, K

doi:10.1016/s0002-9270(98)00289-5

Cited by 56 publications

(63 citation statements)

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“…37 Such mucosal atrophy in non-FAP patients with GA is generally considered to be induced by H pylori infection. 39 In our study however, H pylori was only detected in 58% of FAP patients with GA (table 2). Our H pylori negative patients with GA showed a significantly higher PG I/PG II ratio than in H pylori positive patients with GA (4.0 (0.8) v 2.7 (1.2); p<0.05).…”

Section: Discussioncontrasting

confidence: 57%

Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis

Nakamura

2002

Gut

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Section: Discussioncontrasting

confidence: 57%

Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis

Nakamura

2002

Gut

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“…Atrophic gastritis was associated with increased risk of both the intestinal and diffuse histological subtypes of non-cardia cancer but the association was stronger for the former as previously reported 37 39 40. Whereas the intestinal subtype is nearly always a consequence of atrophic gastritis and intestinal metaplasia, the diffuse histological subtype sometimes develops in a non-atrophic stomach with a strong genetic predisposition being an important factor in some of these cases 41 42…”

Section: Discussionmentioning

confidence: 67%

Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer

Derakhshan

Malekzadeh

Watabe

et al. 2008

Gut

168

138

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INTRODUCTIONAtrophic gastritis is a risk factor for non-cardia gastric cancer, and gastro-oesophageal reflux disease (GORD) for oesophageal adenocarcinoma. The role of atrophic gastritis and GORD in the aetiology of adenocarcinoma of the cardia remains unclear. We have investigated the association between adenocarcinoma of the different regions of the upper gastrointestinal tract and atrophic gastritis and GORD symptoms.

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“…The present results suggest that infection with virulent H. pylori is associated with corpus dominant gastritis even in patients who do not develop gastric cancer. In a recent Japanese study, higher gastritis scores were observed for fundic mucosa than for pyloric mucosa both in patients with intestinal-type cancer and in control subjects [8]. Severe expression of corpus gastritis does not therefore seem to be a specific characteristic of patients with gastric cancer in Japan.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of the applicability of the gastric carcinoma risk index for intestinal type cancer in Japanese patients infected with Helicobacter pylori

et al. 2000

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The gastric carcinoma risk index is a histological criteria to Helicobacter pylori-infected patients with a high risk of gastric cancer. The aim of this study was to examine the applicability of this index for the intestinal-type gastric cancer in Japanese patients with H. pylori infection. In 55 patients with early intestinal-type gastric cancer and 69 control subjects, we calculated the gastric cancer risk index score by evaluating the grade of mononuclear cell (MNC) and polymorphonuclear cell (PMN) infiltration and the presence of intestinal metaplasia. The gastric cancer index score was significantly higher in patients with gastric cancer (P<0.01). The presence of intestinal metaplasia was significantly more frequent in cancer patients than in controls, while infiltration of MNCs or PMNs in the corpus was not different in the two groups. Within the gastric cancer risk index, the presence of intestinal metaplasia was the only criteria associated with the development of intestinal-type gastric cancer in Japan. The gastric cancer risk index may not be applicable to identify H. pylori-positive patients at high risk of developing intestinal-type gastric cancer in Japan.

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Helicobacter pylori infection and gastric neoplasia: correlations with histological gastritis and tumor histology

Abstract: Our results confirm a strong association between H. pylori and gastric carcinoma and adenoma. The intestinal-type gastric carcinoma is associated with atrophic gastritis and IM.

Cited by 56 publications

References 0 publications

Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis

Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis

Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer

Evaluation of the applicability of the gastric carcinoma risk index for intestinal type cancer in Japanese patients infected with Helicobacter pylori

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