Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer

Derakhshan, Mohammad H.; Malekzadeh, Reza; Watabe, Hirotsugu; Yazdanbod, Abbas; Fyfe, Valerie; Kazemi, Abbass; Rakhshani, Naser; Didevar, Reza; Sotoudeh, Masoud; Zolfeghari, Abbass; McColl, Kenneth E.L.

doi:10.1136/gut.2007.137364

Cited by 168 publications

(157 citation statements)

References 49 publications

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“…In a cohort study in 2007 it was revealed that gastric cancer risk in smokers was twice more than non-smokers (Sjodahl et al, 2007) and in some other studies there was a strong association between smoking and gastric cancer (Pisani et al, 1997;Sasazuki et al, 2002;Derakhshan et al, 2007).The general trend of gastric cancer is rather similar to that of smoking where there is a decline in smoking in the developed countries and an increase in developing countries. Although we don't have exact information about smoking prevalence in the population of the country, but considering the extensive media pressure against smoking side effects, smokers population expected to decline in recent decades and not to have much impact on the status of gastric cancer incidence in Iran.…”

Section: Discussionmentioning

confidence: 97%

Trend Analysis of Gastric Cancer Incidence in Iran and Its Six Geographical Areas During 2000-2005

Haidari

Nikbakht²,

Pasdar³

2012

Asian Pacific Journal of Cancer Prevention

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Objective: gastric cancer is the fourth most common cancer worldwide . While it is one of the most common cancers in Iran, there are only limited data regarding incidence trends in the country. This study is the first of its type to investigate trends across six geographical areas during 2000-2005 using cancer registry data. Materials and methods: The registered data for gastric cancer cases in National Cancer Registry System were extracted from the Ministry of Health and Medical Education, Center for Disease Control & Management, code C16. First, according to WHO population, the sex-standardized incidence rate in both sexes and then the trends of incidence rate during 2000-2005 were investigated separately for different geographical areas of the country. Results: the incidence rates of gastric cancer in Iran and its six geographical areas during 2000-2005 were increasing albeit with differences in their slopes. The overall incidence rate increased from 2.8 in 2000 to 9.1 per 100,000 persons per year in 2005, rising from 4.1 to 13.2 in men. The average six-year incidence of gastric cancer in the central and northwestern border of Caspian Sea was 7.8 per 100,000 persons per year, while it was 0.9 per 100,000 persons per year in the border of the Persian Gulf. Generally the incidence rate in men was higher than in women. Conclusion: Iran is one of the high-risk areas for gastric cancer. Increase in incidence might continue in the future partly because of improvement in cancer registry systems as well as increase in risk of this cancer.

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Section: Discussionmentioning

confidence: 97%

Trend Analysis of Gastric Cancer Incidence in Iran and Its Six Geographical Areas During 2000-2005

Haidari

Nikbakht²,

Pasdar³

2012

Asian Pacific Journal of Cancer Prevention

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“…A combination of high prevalence of Helicobacter pylori infection, westernized diet and low intake fruits and vegetables resulted in the increase in incidence and by extension in the mortality (Ashktorab et al, 2007;Derakhshan et al, 2008). Except for Ardabil, stomach cancer has a steady rate in other parts of Iran (Babaei et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Estimation of the Projections of the Incidence Rates, Mortality and Prevalence Due to Common Cancer Site in Isfahan, Iran

Moradpour

Fatemi²

2013

Asian Pacific Journal of Cancer Prevention

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Background: Accurate statistics on the cancer burden are essential, both for purposes of research and for setting priorities in healthcare management. So that in vast countries with partial registration coverage, such as Iran, local data are more useful. We here estimated the incidence, prevalence and mortality time trend of four major cancer site, lung, stomach, breast and prostate, over the period 2001-2010 and provided short-range projections to 2015 in Isfahan. Materials and Methods: Estimates were derived by applying the mortality-incidence analysis method, a back-calculation approach to estimate and project incidence, prevalence and mortality of chronic degenerative disease, starting from knowledge of mortality and relative survival information. Results: Age adjusted incidence, mortality and prevalence rates in Isfahan exhibited a clear upward trend for all four sites during the period 2001-2015, with marked increasees in prostate and breast predicted for the future. Difference in incidence trends between males and females might be attributable to the difference in risk factors specific to certain cancer sites, with smoking being the main risk factor. Conclusions: In this study, males and females displayed an increasing pattern for incidence and mortality rate over the entire study period until 2015. This information can be used as basis for planning healthcare management and allocating recourses in public health.

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“…This variation could be attributed to risk factor prevalence in these different populations. A major risk factor for non-cardia gastric cancer is Helicobacter pylori infection; obesity and gastroesophageal reflux are associated with cancer in the cardia [43][44][45][46]. NHWs had a substantially higher proportion of cardia gastric cancer than Asians, yet even after stratification by anatomic demarcation, 5-year survival remained poor.…”

Section: Discussionmentioning

confidence: 99%

Examining the gastric cancer survival gap between Asians and whites in the United States

et al. 2016

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Background Globally, Asian countries bear a disproportionate gastric cancer burden. Asian Americans, the fastest growing minority population in the US, have higher gastric cancer survival than non-Hispanic whites (NHWs) despite higher incidence. Benefitting from uniform cancer registry standards within the US, we examine for the first time the heterogeneity in the Asian American population, which may elucidate the causes of these disparities. Methods SEER gastric cancer data from 2000 to 2012 were used to calculate 5-year survival estimates for NHWs and the six largest Asian ethnicities. Multivariate analyses were performed to identify critical prognostic factors and survival disparities between Asian groups and NHWs. Results We analyzed 33,313 NHW and 8473 Asian gastric cancer cases. All Asian groups had significantly higher 5-year survival than NHWs, at 29.8%. Among Asians, Koreans and Vietnamese had the highest and lowest survival, at 45.4% and 35.7%, respectively. The Korean survival advantage was largely attributable to relatively high proportions of localized stage and low proportions of cardia tumors. After adjusting for major prognostic factors, the survival disadvantage of NHWs, while attenuated, remained significant in comparison to all Asian groups (HR: 1.33, 95% CI: 1.24-1.43; reference: Korean). The survival disparities within the Asian groups vanished with adjustment. Conclusions This study characterizes distinctive gastric cancer survival patterns among the six major Asian groups and NHWs in the US. The favorable survival for Koreans is largely attributable to specific clinical factors, particularly stage at diagnosis. The causes of the survival disadvantage for NHWs remain elusive.

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Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer

Cited by 168 publications

References 49 publications

Trend Analysis of Gastric Cancer Incidence in Iran and Its Six Geographical Areas During 2000-2005

Trend Analysis of Gastric Cancer Incidence in Iran and Its Six Geographical Areas During 2000-2005

Estimation of the Projections of the Incidence Rates, Mortality and Prevalence Due to Common Cancer Site in Isfahan, Iran

Examining the gastric cancer survival gap between Asians and whites in the United States

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