Helicobacter pylori infection and Gastric Cancer.

Abstract

According to several prospective controlled epidemiologic studies, the positive rate of H. pylori antibody was showen to be higher in the patients with gastric cancer than in the control group. Retrospective studies on the association between gastric cancer and H. pylori have been conducted in a large numberof subjects and the results can be classified broadly into two categories, i.e., findings affirming an association and others denying it. Research concerning the association between gastric cancer and H. pylori has achieved great progress over time, leading to the recognition of this relationship by the WHO. One of the greatest concerns is to ascertain whether the final outcome of H. pylori-induced gastritis may lead to gastric cancer. The onset of gastric cancer can be explained as being caused not only by H. pylori infection, but also by a combination of various factors such as food and the environment. However, the possibility that the occurrence of gastric cancer, like the recurrence of peptic ulcer, can be prevented by eradication of H. pylori has also been suggested. Further progress in clinical research is needed to resolve this issue. (Internal Medicine 41: 1-6, 2002)

A new approach for elimination of gastric cancer deaths in Japan

“…Intervention studies that assessed the preventative effect of H. pylori eradication on gastric cancer have been conducted in healthy individuals worldwide 13–17. In the United States and Europe, however, most studies were terminated before enrolling enough subjects for significant analysis because the incidence of gastric cancer is extremely low in these countries 18, 19.…”

Helicobacter pylori infection among Japanese children

“…In Japan, the prevalence of H. pylori infection was approximately 5% among those under 10 years of age and approximately 19% for teenagers. 9 However, there are few reports describing H. pylori infection among young children in Japan. The aim of the present study was to identify risk factors associated with H. pylori in school‐aged children.…”

Genetic variations of prostate stem cell antigen (PSCA) contribute to the risk of gastric cancer for Eastern Asians: A meta-analysis based on 16792 individuals

“…The etiology and risk factors for intestinal-and diffuse-type GC have been proven to be somewhat different (Solcia et al, 1996;Tahara, 2004). H. pylori infection was proven to play a predominant role in the development of intestinal-type GC (Asaka, 2002;Xia and Talley, 2001). Similarly, the genetic risk factors for intestinal-and diffuse-type GC, and for different stages of GC, are partially different (Tahara, 2004).…”

“…Environmental factors (Moy et al, 2010), bacterial infection (Helicobacter pylori, H. pylori) (Asaka, 2002;Correa, 1992) and genetic factors (Shanks and El-Omar, 2009) have been proven to play very important roles in this process. Although there is a high rate of H. pylori infection in Eastern Asians, very low proportion of patients will develop GC, which indicates the importance of the host susceptibility for GC development (Peek and Blaser, 2002).…”