Helicobacter pylori infection and insulin-dependent diabetes mellitus

Luis, Daniel Antonio de; Calle, Hermenegildo de la; Roy, Garbiñe; Argila, Carlos Martín de; Valdezate, Sylvia; Cantón, Rafael; Boixeda, D

doi:10.1016/s0168-8227(97)00127-7

Cited by 66 publications

(60 citation statements)

References 15 publications

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“…Some studies show greater prevalence than the one found in the controls, and others show similar prevalence (8). On the other hand, some authors reported lower frequency of infection in those patients that had the disease for a longer time, due to the repeated use of antibiotics (25). This may be the explanation for the relatively low proportion of infections by H. pylori in the group of diabetic patients in the present study: they may have been treated countless times with antibiotics during the prolonged course of their disease.…”

Section: Discussionmentioning

confidence: 92%

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Faria

Pavin

Parisi

et al. 2015

Arch. Endocrinol. Metab.

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Objectives: To evaluate, in a group of patients with long-standing type 1 diabetes (DM1), an association of dyspepsia symptoms with: changes in the gastroduodenal mucosa, infection by Helicobacter pylori, glycemic control, and psychological and nutritional factors. Subjects and methods: A total of 32 patient with DM1 were studied (age: 38 ± 9 years; females: 25; diabetes duration: 22 ± 5 years). All patients answered a standardized questionnaire for the evaluation of gastrointestinal symptoms and underwent upper gastrointestinal endoscopy, with gastric biopsies for the evaluation of Helicobacter pylori infection. The presence of anxiety and depression was evaluated by the HAD scale. Nutritional parameters were BMI, arm and waist circumference, skinfold measurement, and body fat percentage. Results: Upper endoscopy detected lesions in the gastric mucosa in 34.4% of the patients, with similar frequency in those with (n = 21) and without dyspepsia (n = 11). The patients with dyspepsia complaints showed greater frequency of depression (60% vs. 0%; p = 0.001), higher values for HbA1c (9.6 ± 1.7 vs. 8.2 ± 1.3%; p = 0.01) and lower values for BMI (24.3 ± 4.1 vs. 27.2 ± 2.6 kg/m 2 ; p = 0.02), body fat percentage (26.6 ± 6.2 vs. 30.8 ± 7.7%; p = 0.04), and waist circumference (78.7 ± 8 vs. 85.8 ± 8.1 cm; p = 0.02). No association was found between the symptoms and the presence of Helicobacter pylori. Conclusions: Dyspepsia symptoms in patients with long-standing DM1 were associated with glycemic control and depression, and they seem to negatively influence the nutritional status of these patients. Arch Endocrinol Metab. 2015;59(2):129-36

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Section: Discussionmentioning

confidence: 92%

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Faria

Pavin

Parisi

et al. 2015

Arch. Endocrinol. Metab.

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“…Some studies have shown a higher prevalence of H.pylori infection in people with type 1 (de Luis et al, 1998; El-Eshmawy et al, 2011) and type 2 diabetes (Bener et al, 2007;Devrajani et al, 2010). This relationship seems to be correlated with gender (Hamed et al, 2008), BMI (Bener et al, 2007;Perdichizzi et al, 1996), the duration of diabetes (de Luis et al, 1998), the presence of dyspepsia, cardiovascular autonomic neuropathy (Gulcelik et al, 2005) and glycated hemoglobin (Chen and Blaser, 2012;Hsieh et al, 2013), whilst other studies have indicated neutral or even negative results (Anastasios et al, 2002;Demir et al, 2008;Gillum, 2004). These contradictory findings might well be due to the different study populations.…”

Section: Discussionmentioning

confidence: 95%

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli

Giuffrida

Piazzese

et al. 2015

Journal of Reproductive Immunology

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“…13 Sero prevalence of Helicobacter pylori among IDDM patients aged <24 year was significantly higher than controls and corresponding rate among IDDM aged >24 years was significantly lower than control. 6 An early age of acquisition of infection in the developing countries has been seen. 14,15 In factin most under developed countries an endemic of Helicobacter pylori goes unchecked and most adults are infected.…”

Section: Discussionmentioning

confidence: 99%

“…First, altered glucose metabolism may produce chemical changes in the gastric mucosa that help to detect H. pylori infection. 6 Second, H. pylori gastric infection increases secretion of pro inflammatory cytokines, resulting in changes in the structure of insulin receptor interfering with the interaction between its receptor and insulin. 2 …”

Section: Introductionmentioning

confidence: 99%

A study of Helicobacter pylori infection in diabetes mellitus

2016

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Background: Helicobacter pylori is the most common bacterial infection in human beings. The aim was to study the association of Helicobacter pylori infection in patients of diabetes mellitus. Design of the study was observational analytic cross sectional study. Methods: A total of 69 subjects were studied. Of these 30 were non diabetics and 39 were diabetics, with disease duration more than 1 year. The serological diagnosis of H. pylori was made by Anti-Helicobacter pylori antibody test. Antral biopsies of all diabetic patients were taken during endoscopy and subjected to histological examination. Results: The mean age for the diabetics was 48.9±9.86 years and that of non-diabetics was 47.9±9.16 years. The majority of the subjects belonged to fifth and sixth decades. There was conspicuous male preponderance in both the diabetics and the nondiabetics group, more attributable to the selection bias. Serum samples of all the subjects were tested for the presence of IgG against Helicobacter pylori. Helicobacter pylori was positive in 40% of non-diabetics and 64.1% of diabetics X 2 = 3.96, p value=0.047 (p<0.05) i.e. the prevalence of Helicobacter pylori in diabetics is significantly higher than that in non-diabetics. Histological examination of antral biopsies (known to be the gold standard method of diagnosing Helicobacter pylori) was performed in all diabetics and comparison of the type of diabetes, duration of diabetes, and level of glycaemia and complications of diabetes were made in patients of diabetes with and without Helicobacter pylori. This study showed patients with IDDM had higher positivity (75%) than those of NIDDM (67.6%). The mean duration of diabetes with Helicobacter pylori group was 7.85+3.93 years, and higher than that of diabetics without Helicobacter pylori which was 5.83±2.52. The mean fasting blood sugar was 192±60.3 mg/dl in diabetics with Helicobacter pylori group and was higher than that of diabetics without Helicobacter pylori group which was 167±37.1mg/dl. The mean post prandial blood sugar in diabetics with Helicobacter pylori group was 318±78.4mg/dl and was more than that of diabetics without Helicobacter pylori group in whom it was 280±49.7mg/dl. The two diagnostic modalities viz serological and histological identification of Helicobacter pylori correlated well with each other. It was observed that serological diagnosis by Anti-Helicobacter pylori antibody test is 80% sensitive and 75% specific. Conclusions: The prevalence of Helicobacter pylori is higher in diabetics than the non-diabetics. The prevalence of Helicobacter pylori infection had no significant correlation with duration of diabetes, type of diabetes, glycaemia levels of diabetics and complications of diabetics. The serological diagnosis of H. pylori was made by AntiHelicobacter pylori antibody test, by Biochem Immuno systems ITALIA SPA ELAGEN Helicobacter pylori IgG Kit. This ELISA technique is 80% sensitive and 75% specific.

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Helicobacter pylori infection and insulin-dependent diabetes mellitus

Cited by 66 publications

References 15 publications

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

A study of Helicobacter pylori infection in diabetes mellitus

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