Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli, Simona; Giuffrida, Domenica; Piazzese, Annalisa; Todros, Tullia

doi:10.1016/j.jri.2015.02.004

Cited by 24 publications

(22 citation statements)

References 35 publications

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“…A logistic regression analysis showed that gestational diabetes mellitus (GDM) was the most common maternal complication (5.7%) and the only pregnancy‐related disorder with a significantly higher rate of H. pylori ‐positive women (41.3% vs 27.7%; P <.001; OR=1.829, 95% CI=1.320–2.533). These findings suggest that H. pylori eradication might play a role in the prevention of GDB …”

Section: Uro‐gynecologic Diseasesmentioning

confidence: 77%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro-gynecologic diseases, as well as diabetes mellitus and metabolic syndrome, with very promising results. This review has been aimed at summarizing the results of the most relevant studies published over the last year on this fascinating topic.

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Section: Uro‐gynecologic Diseasesmentioning

confidence: 77%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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“…The primary outcomes we focused on were preeclampsia and fetal growth restriction. Sixteen studies with a total of 10 402 women reported the influence of H pylori infection on the risk of preeclampsia. Pooled results suggested an OR of 2.51 (95% CI: 1.88‐3.34; P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…One medium quality study changed the between‐study heterogeneities materially on the result of fetal growth restriction, and after deleting it, the heterogeneity decreased ( I 2 = 48%; P = 0.12) and the association still remains significant. As to the result of low birthweight, one study whose participants partly had pregnancy complications which may confound the result. After deleting, the heterogeneity reduced ( I 2 dropped from 72% to 56%) and made the association statistically significant (OR: 1.59; 95% CI: 1.05‐2.40; P = 0.03).…”

Section: Resultsmentioning

confidence: 99%

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Zhan

et al. 2019

Helicobacter

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Objective To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes. Materials and Methods A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Subgroup analysis and sensitivity analysis were performed. Results Thirty‐one studies with a total of 22 845 participants were identified. There was significant association of H pylori infection with preeclampsia (OR: 2.51; 95% CI: 1.88‐3.34; P < 0.001), fetal growth restriction (OR: 2.28; 95% CI: 1.21‐4.32; P = 0.01), gestational diabetes mellitus (OR: 2.03; 95% CI: 1.56‐2.64; P < 0.001), spontaneous abortion (OR: 1.50; 95% CI: 1.05‐2.14; P = 0.024), and birth defect (OR: 1.63; 95% CI: 1.05‐2.54; P = 0.03). Sensitivity analysis showed the significant association between H pylori infection and low birthweight (OR: 1.59; 95% CI: 1.05‐2.40; P = 0.03). Conclusion The present meta‐analysis offers proof to support that H pylori infection during pregnancy can increase the risk on adverse pregnancy outcomes. Screening and treating for H pylori infection before pregnancy should be taken into account.

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“…The total number of excess deaths attributable to diabetes worldwide was estimated to be 3.96 million in the age group 20-79 years, 6.8% of global mortality. Diabetes accounted for 6.0-15.7% deaths depending on the country.…”

Section: Introductionmentioning

confidence: 99%

“…The latest data link the presance of Hp with the development of several diseases among which are type 2 diabetes mellitus (T2DM), chronic obstructive bronchitis, acute coronary disease, end stage renal disease (ESRD), and others [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

Russ. Open Med. J.

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Abstract:The incidence and prevalence of type 2 diabetes mellitus is considered to be one of the most critical problems in the healthcare system. The pathophysiology of the disease has proven to be complicated and multiple factors are involved in its development. Recently Helicobacter pylori was proposed as a new risk factor for developing type 2 diabetes mellitus as well as other disease. This study is a review of the current data involving Helicobacter pylori association with type 2 diabetes mellitus and its complications.

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Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cited by 24 publications

References 35 publications

Helicobacter pylori and extragastric diseases

Helicobacter pylori and extragastric diseases

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

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