Helicobacter pylori Infection and Severity of Reflux-Induced Esophageal Disease in a Cohort of Patients with Columnar-Lined Esophagus

Abstract

The relationship between Helicobacter pylori infection and reflux-induced esophageal diseased is controversial. We examined esophageal disease severity in patients with columnar-lined esophagus and compared results between patients with and without Helicobacter pylori infection. Medical records of 1000 patients diagnosed with columnar-lined esophagus were examined. Endoscopic and histological findings of reflux-induced esophageal disease were compared between H. pylori-positive and H. pylori-negative patients. Four hundred twenty-nine patients (42.9%) showed evidence of H. pylori status, of whom 239 (55.7%) were positive and 190 (44.3%) negative. There were no significant differences in length of columnar-lined segment (P = 0.305), frequency of associated esophagitis (P = 0.583), or presence of gastroduodenal inflammation (P = 0.335, P = 0.131) between the two groups. Histological grade of esophageal disease severity was similar between them, with no statistically significant differences (P = 0.231). We conclude that in patients with established columnar-lined esophagus, there appears to be no difference in severity of reflux-induced esophageal disease between those with and those without H. pylori infection.

Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy

“…Indeed, the prevalence of H. pylori was shown to be similar between GERD and other patients, and H. pylori was not related to the severity of GERD. [ 5 6 ] Recently, Japanese studies suggested that after H. pylori eradication, GERD symptoms are relieved, and life quality improved. [ 7 8 ] The Management of Helicobacter pylori Infection the Maastricht IV/Florence Consensus Report declares that H. pylori status has no effect on symptom severity, symptom recurrence and treatment efficacy in GERD.…”

Comparative genomic analysis of esophageal cancers

“…Low‐grade dysplasia has a threefold increased risk of progression to OAC compared with nondysplastic epithelium . No difference in severity of reflux‐induced esophageal disease was observed in BE patients with or without Helicobacter pylori infection …”

Helicobacter pyloriand gastroesophageal reflux disease: a review of this intriguing relationship

“…reviewed 26 studies for evidence of an association between GERD and H. pylori infection and found a lower prevalence of infection in patients with GERD than in those without GERD 21 . While other studies have yielded similar results, 17,22–24 many have found no differences between H. pylori infection rates in patients with GERD and those in controls 25–29 …”