Helicobacter pylori infection and the risk of acute coronary syndrome: a nationwide retrospective cohort study

Lai, Chun-Ting; Yang, Tse-Yen; Lin, Chia-Wei; Kao, Chia Hung

doi:10.1007/s10096-014-2207-7

Cited by 34 publications

(27 citation statements)

References 29 publications

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“…A nationwide retrospective cohort study recently performed by Lai et al [2] clearly demonstrated that H. pylori infection significantly increases the risk of acute coronary syndrome even after adjustment for potential confounding factors and that the overall adjusted OR increases with age (from 3.11 to 8.24). Moreover, Liu et al [3] performed a meta-analysis of 26 studies involving more than 20,000 patients demonstrating a significant association between H. pylori infection and the risk of myocardial infarction (OR 2.10, 95% CI: 1.75-2.53).…”

Section: Cardiovascular Diseasesmentioning

confidence: 98%

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Extragastric Diseases and Helicobacter pylori

Franceschi¹,

2015

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The extragastric manifestations of Helicobacter pylori infection still remain a very strong topic throughout the H. pylori world. Indeed, H. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that H. pylori may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions. Different pathogenic mechanisms have been hypothesized, including the induction of a low-grade inflammatory state and the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic in the last year.There is a very strong interest of researchers from all over the world in the extragastric manifestations of Helicobacter pylori infection, as demonstrated by the high number of studies published in this field during the last year. Indeed, H. pylori is a very good model for studying host-bacterial interactions and very attractive for those interested in the role of gut microbiota in health and disease [1]. Here, we shall summarize the results of the most relevant studies published on this topic from

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Section: Cardiovascular Diseasesmentioning

confidence: 98%

“…A nationwide retrospective cohort study recently performed by Lai et al. clearly demonstrated that H. pylori infection significantly increases the risk of acute coronary syndrome even after adjustment for potential confounding factors and that the overall adjusted OR increases with age (from 3.11 to 8.24). Moreover, Liu et al.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Extragastric Diseases and Helicobacter pylori

Franceschi¹,

2015

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“…Although a link is not as strong as that of ITP, H. pylori infection has also been associated with cardiovascular diseases (CVD), immune-mediated diseases, and neurological diseases. Similar to ITP, H. pylori infection appears to increase the risk of CVD, 95 DM, 96 and AD. 97–99 In contrast, H. pylori infection seems to decrease the risk of asthma, 100–102 IBD, 103 and MS. 104–106 Thus, H. pylori infection may play contrasting roles in two neurological diseases: a detrimental role for AD and a protective role for MS.…”

Section: Helicobacter Pylori Infection In Ms and Admentioning

confidence: 95%

Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies

Park

Omura

Fujita

et al. 2017

Clinical & Exp Neuroim

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Alteration of microbiota has been associated with intestinal, inflammatory, and neurological diseases. Abundance of “good bacteria” such as Bifidobacterium, or their products have been generally believed to be beneficial for any diseases, while “bad bacteria” such as pathogenic Helicobacter pylori are assumed to be always detrimental for hosts. However, this is not the case when we compare and contrast the association of the gut microbiota with two neurological diseases, multiple sclerosis (MS) and Alzheimer’s disease (AD). Following H. pylori infection, pro-inflammatory T helper (Th)1 and Th17 immune response are initially induced to eradicate bacteria. However, H. pylori evades the host immune response by inducing Th2 cells and regulatory T cells (Tregs) that produce anti-inflammatory interleukin (IL)-10. Suppression of anti-bacterial Th1/Th17 cells by Tregs may enhance gastric H. pylori propagation, followed by a cascade reaction involving vitamin B12 and folic acid malabsorption, plasma homocysteine elevation, and reactive oxygen species induction. This can damage the blood-brain barrier (BBB), leading to accumulation of amyloid-β in the brain, a hallmark of AD. On the other hand, this suppression of pro-inflammatory Th1/Th17 responses to H. pylori has protective effects on the hosts, since it prevents uncontrolled gastritis as well as suppresses the induction of encephalitogenic Th1/Th17 cells, which can mediate neuroinflammation in MS. The above scenario may explain why chronic H. pylori infection is positively associated with AD, while it is negatively associated with MS. Lastly, we list “10 pitfalls of microbiota studies”, which will be useful for evaluating and designing clinical and experimental microbiota studies.

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“…However, the overall adjusted hazard ratio of acute coronary syndrome increased with increasing age with a 3.11 to 8.24 adjusted hazard ratio among the various age groups. Several comorbidities, such as diabetes, hyperlipidemia, and chronic obstructive pulmonary disease exhibited synergistic effects for acute coronary syndrome risk [46].…”

Section: Figure 2 An Overlap In Hp Infection and T2dmmentioning

confidence: 99%

Untitled

2016

Russ. Open Med. J.

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Abstract:The incidence and prevalence of type 2 diabetes mellitus is considered to be one of the most critical problems in the healthcare system. The pathophysiology of the disease has proven to be complicated and multiple factors are involved in its development. Recently Helicobacter pylori was proposed as a new risk factor for developing type 2 diabetes mellitus as well as other disease. This study is a review of the current data involving Helicobacter pylori association with type 2 diabetes mellitus and its complications.

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Helicobacter pylori infection and the risk of acute coronary syndrome: a nationwide retrospective cohort study

Cited by 34 publications

References 29 publications

Extragastric Diseases and Helicobacter pylori

Extragastric Diseases and Helicobacter pylori

Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies

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