Helicobacter Pylori Infection: Association with Hashimoto’s Thyroiditis

Korani, Mohamed

doi:10.15406/ghoa.2016.04.00111

Cited by 4 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could subsequently damage the thyroid tissues, thus increasing the disorder's progression. Our results were consistent and were confirmed by a local study (Aboud, 2011) in addition to other regional and international studies (Aghili et al,2013;Shi et al,2013;Korani et al,2016). Otherwise, Bassi et al concluded that the correlation between H. pylori and autoimmune thyroid diseases was found only with Graves's disease and not Hashimoto's.…”

Section: Discussionsupporting

confidence: 92%

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

2022

JJBS

View full text Add to dashboard Cite

The association of different infections with the subsequent occurrence of autoimmunity, just like autoimmune thyroiditis, has recently been increased globally. This study aimed to determine the role of Helicobacter pylori (HP) infection in Hashimoto's disease. The research groups involved 50 patients with Hashimoto's disease and 50 healthy subjects. All of them were subjected to the estimation of concentrations of free triiodothyronine (FT3), free thyroxine (FT4), TSH, antithyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg). In addition, for the diagnosis of HP, IgG, as well as anti-CagA antibodies in the serum, were detected. An independent t-test was used to test the significance of the means. Also, an odd ratio was used to clarify the association between H. pylori infection and HT disease. Statistical significance was detected when P-value is equal to or less than 0.05. The results indicated that 94% of Hashimoto's patients and 34% of the healthy subjects were seropositive for HP IgG. Also, (74%) of the HT patients were seropositive for HP IgG/anti-CagA. These results were significant at the level of 0.01 (p< 0.001). Hashimoto's patients with HP/CagA positive tests have significantly elevated concentrations of anti-TPO (480.69±311.29), anti-Tg (336.00±175.95), and TSH (20.43±18.98) compared with patients tested negatively to HP/CagA antibodies (358.60±281.55, 258.36±170.09 and 9.02±5.94 respectively). In conclusion, there is a relationship between H. pylori infection and the development of Hashimotoʼs thyroiditis in Iraqi patients. H. pylori infection, especially CagA expressing strains, could be a risk factor for the development of autoimmune hypothyroidism and to a lesser extent its progression by increasing the concentration of thyroid antibodies and TSH, which in turn leads to decreased levels of the thyroid hormones and worsening of the disease, requesting antibiotic therapy to eradicate the bacterial infection.

show abstract

Section: Discussionsupporting

confidence: 92%

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

2022

JJBS

View full text Add to dashboard Cite

show abstract

Helicobacter pylori-induced autoimmune thyroiditis: is the pathogenic link concluded or still a hypothesis?

Thiyagarajan¹,

Saini²,

Alruwaili

2018

Reviews in Medical Microbiology

View full text Add to dashboard Cite

Infection caused by Helicobacter pylori is considered as a serious health issue as it can cause severe damage of gastric mucosa, impair the digestive mechanism and even lead to neoplastic disease. Research studies have projected its survival in many parts of the body beyond the gastric system. The ability of these bacteria to withstand the gastric juice and change the surrounding conditions makes its survival in the stomach successful. As an outcome of H. pylori infection, there occurs the release of inflammatory mediators and immune modulators, which could cause further complications. Recent investigations on H. pylori have demonstrated the association of its infection with many systemic diseases including lung cancer, urticaria, type-1 diabetes, autoimmune diseases and so on. Autoimmune thyroiditis (AIT) is an organ-specific autoimmune disease, which occurs as a result of production of autoantibodies to thyroid gland leading to thyroid dysfunction. Antibodies of similar kind produced against H. pylori have been demonstrated for their occurrence in patients suffering with AIT in many studies. On the other hand, some of the studies have experimentally proved the lack of link between H. pylori infection and AIT. As the findings attributing H. pylori infection with the AIT are increasingly reported in recent years, this article reviews the concepts and controversies over their association.

show abstract

Correlation between Autoimmune Hashimoto’s Thyroiditis and Helicobacter pylori Infection: A Case-Control Study

Shajari,

Rezaei,

Osmani

et al. 2024

Middle East J Dig Dis

View full text Add to dashboard Cite

Background: Among environmental factors, infectious agents, including Helicobacter pylori, can act as triggers for autoimmune thyroid diseases. Therefore, this study aimed to investigate the correlation between autoimmune Hashimoto’s thyroiditis with H. pylori infection. Methods: The participants in this case-control study were 74 individuals 17-62 years who were divided into two groups, including 38 diagnosed Hashimoto’s thyroiditis patients from an outpatient clinic of endocrinology and 36 apparently healthy individuals that were selected from family members of cases group age-matched and sex-matched. For individuals in two groups, a questionnaire was completed, including demographic information. Then, they were referred to the laboratory for thyroid stimulating hormone (TSH) and free T4 (FT4) in the control group and anti-thyroid peroxidase antibody (TPO-Ab) levels measurement in case and control groups. Stool samples were obtained from all individuals for H. pylori antigen detection using the ELIZA kit. Results: There was no significant difference in the mean age of case and control groups (P=0.96), and 81.1% of individuals were female. 58.6% of patients with Hashimoto’s thyroiditis and 41.4% of the control group had positive H. pylori, but there was no statistically significant difference between the two groups (P=0.34). Furthermore, there was a significant positive correlation between TPO-Ab levels and H. pylori infection (r=0.2, P=0.03). Conclusion: TPO-Ab levels were associated with H. pylori infection diagnosed by H. pylori antigen.

show abstract

Helicobacter Pylori Infection: Association with Hashimoto’s Thyroiditis

Cited by 4 publications

References 22 publications

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

Helicobacter pylori-induced autoimmune thyroiditis: is the pathogenic link concluded or still a hypothesis?

Correlation between Autoimmune Hashimoto’s Thyroiditis and Helicobacter pylori Infection: A Case-Control Study

Contact Info

Product

Resources

About