Helicobacter Pylori Infection in Children with Type 1 Diabetes Mellitus

Fayed, Sohair B.; Dayem, Soha M. Abd El; Khalil, Ensaf; Kader, Mona Abd El; Halim, Eatemad Abd El

doi:10.3889/oamjms.2014.020

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…The possible reasons for the disparity observed in the prevalence of infection include differences in study populations in terms of age and sample size. Age should be considered as a factor affecting H. pylori infection, as the exposure to H. pylori organisms increases with age [8,14], and it is imperative to compare similar age groups when studying the Based on the results of some studies, many factors can influence the prevalence of H. pylori infection among children with Diabetes, such as age, age at the onset of diabetes, duration of diabetes, BMI, FPG and HbA 1 c1 [10,16]. In one study, Feyad et al Found that children with diabetes and positive H. pylori infection comorbidity are older, have had an earlier onset of diabetes, have a larger BMI and a higher HbA 1 c compared to the negative infected group [10].…”

Section: Discussionmentioning

confidence: 99%

“…The link between T1DM and H. pylori still remains controversial. Some studies have suggested that the high prevalence of this infection in patients with T1DM [10][11][12][13][14] is related to the duration of diabetes, dyspepsia, age, sex, BMI, blood pressure, fasting plasma glucose (FPG) and Hemoglobin A1c (HbA 1 c) level [10,11]. H. pylori infection can lead to hyperglycemia in children with Diabetes Mellitus, and its mechanisms are unknown but are thought to include the secretion of counterregulatory hormones due to stress in addition to the production of cytokines.…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori infection and type 1 diabetes mellitus in children

Dooki

Aghamaleki

Noushiravani

et al. 2020

J Diabetes Metab Disord

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Objectives This study aimed to investigate the association between Helicobacter pylori infection with diabetes mellitus type one and the effect of infected Helicobacter pylori on glycemic control. Methods This case control study was conducted on children with and without type 1 diabetes mellitus (T1DM). Demographic data and gastrointestinal symptoms in both groups and glycemic control status and duration of diabetes were recorded in patients with T1DM. Stool test was done on all children to detect Helicobacter pylori antigen. Results Sixty three children with T1DM with a mean of 10.88 ± 2.84 years and 105 control children with an average age 10.17 ± 2.55 years (P = 0/09) were involved in this study. The frequency of Helicobacter pylori infection in patients with T1DM was 17/ 63 (27%) and 25/105 (23.8%) in control group, (P = 0/64). The frequency of bloating, epigastric pain and nausea was not significantly different between the two groups. The frequency of epigastric pain in children with diabetes with helicobacter infection was significantly higher than non-infected children with diabetes (29.4% vs. 2.2%) (P = 0.004).The mean duration of diabetes (P = 0.53), age diagnosis of diabetes (P = 0.09), fasting blood glucose (P = 0.18), glycosylated hemoglobin (P = 0.08) and the daily insulin dose (P = 0.18) in patients with T1DM with and without helicobacter pylori infection had not significantly different. Conclusions There was no significant association between Helicobacter pylori infection and diabetes in children 5-15 years old, and glycemic control status was not difference in patients with T1DM with and without Helicobacter pylori infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and type 1 diabetes mellitus in children

Dooki

Aghamaleki

Noushiravani

et al. 2020

J Diabetes Metab Disord

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The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis

Chen

Xing

Zhao

et al. 2019

Journal of Diabetes Research

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Background.The association between Helicobacter pylori infection and glycated hemoglobin A has been confirmed in many studies, but these conclusions are still contradictory and controversial. Therefore, we conducted a meta-analysis to resolve the problem of inconsistent results in diabetes.Methods. A comprehensive search was conducted on related researches published in PubMed, Embase, and China Academic Journal Full-text Database (CNKI) from the inception of each database to April 2019. Fixed or random effects model was used to pool the weighted mean difference with 95% confidence interval from individual studies. Subgroup and sensitivity analyses were also performed. Publication bias was estimated by funnel plot, Egger’s test, and fail-safe numbers.Results. 35 studies with 4,401 participants with diabetes were included in the meta-analysis. Glycated hemoglobin A levels were elevated in patients with Helicobacter pylori infection compared with patients without Helicobacter pylori infection (WMD=0.50, 95% CI: 0.28-0.72,p<0.001). In subgroup analysis by the subtype of diabetes, there was a correlation between Helicobacter pylori infection and elevated glycated hemoglobin A in type 1 diabetes (I2=74%,p<0.001,WMD=0.46, 95% CI: 0.12-0.80), and in type 2 diabetes (I2=90%,p<0.001,WMD=0.59, 95% CI: 0.28-0.90,p<0.001). In subgroup analysis by the study design, there was a correlation in cross-sectional study (I2=89%,p<0.001,WMD=0.42, 95% CI: 0.16-0.69,p≤0.003) and in case-control study (I2=83%,p<0.001,WMD=0.39, 95% CI: 0.14-0.64,p≤0.003). By different methods for detecting Helicobacter pylori, there was a correlation in the biopsy group (I2=83%,p<0.001,WMD=0.6, 95% CI: 0.11-1.09,p≤0.03) and in other groups of test methods (I2=87%,p<0.001,WMD=0.37, 95% CI: 0.17-0.56,p<0.001). Sensitivity analysis showed that our results were reliable, and no evidence of substantial publication bias was detected.Conclusion. The meta-analysis might indicate a correlation between Helicobacter pylori infection and glycated hemoglobin A levels in diabetes.

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Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies

et al. 2020

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Background: There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus. Methods: A systematic literature searches of international databases, including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL (January 1990-March 2019) was conducted to identify studies investigating the relationship between H. pylori infection and diabetes mellitus. Only case-control studies were analyzed using odds ratio (OR) with 95% confidence intervals (CIs). Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. Logarithm and standard error logarithm odds ratio (OR) were also used for meta-analysis. Results: A total of 41 studies involving 9559 individuals (case; 4327 and control; 5232) were analyzed. The pooled estimate of the association between H. pylori infection with diabetes was OR = 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I 2 = 86.6%). The effect of H. pylori infection on diabetes mellitus (both types), type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was slightly higher than other population, Conclusion: In overall a positive association between H. pylori infection and diabetes mellitus was found.

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Helicobacter Pylori Infection in Children with Type 1 Diabetes Mellitus

Abstract: Objective: To evaluate H. pylori infection and virulent strain in diabetic children. Patients:In this study 53 type 1 diabetics and 53 of normal volunteers were included.

Cited by 3 publications

References 24 publications

Helicobacter pylori infection and type 1 diabetes mellitus in children

Helicobacter pylori infection and type 1 diabetes mellitus in children

The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis

Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies

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