Helicobacter pylori infection in diabetic patients: prevalence and endoscopic findings

Roussos, Anastasios; Goritsas, Constantin; Papamihail, Christos; Trigidou, Rodoula; Garzonis, Peter; Ferti, Angeliki

doi:10.1016/s0953-6205(02)00094-8

Cited by 71 publications

(65 citation statements)

References 26 publications

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“…This is in agreement with previous studies reported by Candelli et al [10], Anastasios et al [7], Demir et al [8] Xia et al [9], and Ko et al [11]. However, other studies reported a higher prevalence of H. pylori infection in type 2 diabetic patients in comparison to non diabetic subjects [12][13][14][15].…”

Section: Discussionsupporting

confidence: 92%

“…Community based surveys gave conflicting results about the prevalence of gastro-intestinal (GI) tract symptoms in persons with or without DM [5,6]. Some studies reported no difference in H. pylori infection rates between diabetic patients and controls [7][8][9][10][11], while other studies reported a higher rate of H. pylori infection in diabetic patients [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Cytotoxin-Associated Gene Product-A Positive <i>Helicobacter Pylori</i> Strains on Micro-albuminuria in Type 2 Diabetes

Ibrahim¹,

Zaher²,

Ghonemy³

et al. 2010

Arab J. Nephr. Trans

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Introduction: Available data on the possible association between Helicobacter pylori (H. pylori) infection and diabetes mellitus (DM) are contradictory. The prevalence of cytotoxin associated gene product A (cagA) positive H. pylori is high in Egypt. This study aims to examine its association with type 2 DM, and its effect on glycemic control and the occurrence of microalbuminuria. Methods:The study involved 98 dyspeptic type 2 diabetic patients and 102 dyspeptic non-diabetic subjects who underwent upper gastrointestinal tract endoscopy in Zagazig university hospital. H. pylori infection was diagnosed by histopathology and/or culture. The presence of cagA positive strains was confirmed by polymerase chain reaction (PCR) and gel electrophoresis. Fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c) and urinary albumin excretion ratio (UAER) were compared between infected and non-infected diabetic patients.Results: Diabetic patients had similar age and gender distribution but significantly higher body mass index (BMI) compared to controls. The prevalence of H. pylori infection (54.1% versus 56.9%, P = 0.3) and the prevalence of cagA positive H. pylori strains (40.8% versus 36.3%, P =0.1) were not significantly different between the two groups. Diabetic patients infected with cagA positive H. pylori strains had higher mean FBS (199±22 versus 163±20, P=0.00), higher mean HbA1c (8.6±0.8 versus 6.3±0.8, P=0.00) and higher rate of microalbuminuria (67.5% versus 10.3%, P=0.00) than non infected diabetic patients. Conclusion:H. pylori infection with cagA positive strains was similarly common in dyspeptic diabetic patients and controls. It was associated with poorer glycemic control and higher rates of microalbuminuria in diabetic subjects.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Impact of Cytotoxin-Associated Gene Product-A Positive <i>Helicobacter Pylori</i> Strains on Micro-albuminuria in Type 2 Diabetes

Ibrahim¹,

Zaher²,

Ghonemy³

et al. 2010

Arab J. Nephr. Trans

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“…Some studies have shown a higher prevalence of H.pylori infection in people with type 1 (de Luis et al, 1998; El-Eshmawy et al, 2011) and type 2 diabetes (Bener et al, 2007;Devrajani et al, 2010). This relationship seems to be correlated with gender (Hamed et al, 2008), BMI (Bener et al, 2007;Perdichizzi et al, 1996), the duration of diabetes (de Luis et al, 1998), the presence of dyspepsia, cardiovascular autonomic neuropathy (Gulcelik et al, 2005) and glycated hemoglobin (Chen and Blaser, 2012;Hsieh et al, 2013), whilst other studies have indicated neutral or even negative results (Anastasios et al, 2002;Demir et al, 2008;Gillum, 2004). These contradictory findings might well be due to the different study populations.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli

Giuffrida

Piazzese

et al. 2015

Journal of Reproductive Immunology

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“…Previous studies have suggested a higher prevalence of H. pylori infection in patients with diabetes 7,8,9,10 . However other studies 11,12,13 did not reveal significant association of this infection in diabetic patients.…”

Section: Introductionmentioning

confidence: 88%

A Clinical Study on Association of Helicobacter Pylori Infection With Type-2 Diabetes And Depression

Das¹,

Medhi²,

Mathur³

2016

IOSR

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Helicobacter pylori infection in diabetic patients: prevalence and endoscopic findings

Cited by 71 publications

References 26 publications

Impact of Cytotoxin-Associated Gene Product-A Positive <i>Helicobacter Pylori</i> Strains on Micro-albuminuria in Type 2 Diabetes

Impact of Cytotoxin-Associated Gene Product-A Positive <i>Helicobacter Pylori</i> Strains on Micro-albuminuria in Type 2 Diabetes

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

A Clinical Study on Association of Helicobacter Pylori Infection With Type-2 Diabetes And Depression

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