Helicobacter Pylori Infection in Peptic Ulcer Disease

Tsang, Tat-Kin; Shrestha, Manish P.

doi:10.5772/24889

Cited by 7 publications

(28 citation statements)

References 242 publications

(236 reference statements)

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“…In this study homB, iceA and dupA were also leading triggers of gastritis, and Peptic ulcer disease. These finding are close to the study of Tsang et al [16] who stated that dupA is correlated with a raised risk for duodenal ulcer. Lu et al [17].…”

Section: Discussionsupporting

confidence: 91%

Association of dupA, iceA, homB Genes of Helicobacter pylori with Gastritis, Peptic Ulcer Disease and Gastric Cancer

Bajwa

Idrees²,

Maheshwari

2020

JPRI

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Objective: To determine the association of dupA, iceA, homB genes of Helicobacter pylori with gastro-duodenal diseases such as gastritis, peptic ulcer disease PUD and gastric cancer. Materials and Methods: This cross-sectional analytical study was conducted at Gastroenterology Department, Shaikh Zayed Hospital Lahore. Patients with gastro-duodenal diseases and positive H. pylori were included. Gastric biopsies were taken from fundus, body and antrum. H. pylori DNA were removed utilizing Gentra DNA extraction Kit (Life Technologies, USA) as per the technique and Qualitative PCR for the recognition of H. Pylori DNA. The PCR primers sets were designed for the specific detection of dupA, iceA and homB genes of H. pylori. All the data was recorded in proforma and analyzed by SPSS version 20. Results: Mean age of the cases was 41.22+8.04 years. Males were more affected 118(60.2%). HomB was the most common 76(38.8%) followed by dupA and iceA 28.6% and 24.5% respectively. Peptic ulcer disease and gastritis were higher among patients having dup A and iceA positive strains as compared to homB gene patients, while gastric cancer was significantly higher among HomB gene infected patients, p-values were quite significant. Conclusion: It was concluded that homB gene was most frequent in H. pylori infected population. Peptic ulcer disease and gastritis are markedly associated with dupA and iceA genes, while homB gene infected patients are at high risk of gastric cancer.

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Section: Discussionsupporting

confidence: 91%

Association of dupA, iceA, homB Genes of Helicobacter pylori with Gastritis, Peptic Ulcer Disease and Gastric Cancer

Bajwa

Idrees²,

Maheshwari

2020

JPRI

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“…pylori (H. pylori) seems to play a significant role in the development of Peptic ulcer disease (PUD), a disease which is said to affect more that 10% of the world's population [1]. From the global perspective, H. pylori infection affects above 50% of the world's population, and is known to affect at least one-third of the young people especially children [2,3]. Up to 90% of the children in the developing countries get infected by H. pylori where as in the developed countries it has 1.8-65% prevalence rate [4].…”

Section: Introduction 11 Backgroundmentioning

confidence: 99%

“…Literature shows that there are both invasive and non-invasive diagnostic investigations that can be used to determine the presence of the infection [2,12]. The recommended management approach is the screen-and-treat strategies [3].…”

Section: Introduction 11 Backgroundmentioning

confidence: 99%

Helicobacter pylori Infection in Peptic Ulcer Disease among Young People

Weytey¹

2022

Peptic Ulcer Disease - What's New?

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Peptic Ulcer Disease (PUD) is a common chronic disease of the Gastrointestinal Tract (GIT) worldwide, affecting 87.4 million people with 257,500 mortality turnouts in the year 2015. PUD is a painful open sore that develops in the wall lining of the lower part of the esophagus, the stomach, or the duodenum. PUD has both internal and external causative factors, of which Helicobacter pylori (H. pylori) is a major role player, accounting for 70–95% of its prevalence rate globally. H. pylori infection is acquired generally during the younger ages of life with its various mode of transmission, and with a prevalence rate of 90% in some developing countries, but remains asymptomatic till later years in life. This chapter attempts to provide the overview of H. pylori infection among young people, since they differ from the elderly, in terms of its prevalence rate, its risk factors, its complication rate, its diagnostic tests and managements, and its higher rate of antibiotic resistance.

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“…pylori is a gram-negative, spiral and microaerophilic bacterium that causes gastritis and it may lead to pyloric and intestinal ulcers, iron and vitamin B12 deficiencies, gastric adenocarcinoma and primary B-cell lymphoma (3). H. pylori is recognized as the most common cause of gastritis and also as one of the most important factors which develop gastrointestinal complications as well as indigestion symptoms (2,4). It is essential to eliminate H. pylori completely, if we want to treat the related PUD (5), reduce gastrointestinal ulcer recurrence and prevent gastrointestinal ulcer in patients who should take NSAIDs (6).…”

Section: Introductionmentioning

confidence: 99%

“…While endoscopy procedure, rapid urease test (RUT) is considered as the first choice. Other tests include histologic evaluation, culture and PCR (2).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Peptic Ulcer Disease in Asymptomatic Subjects Referring to the Check- Up Clinic of Razavi Hospital from 2006 - 2011

Abdolhosseini¹,

Sarraf²,

Tayebi³

et al. 2014

Razavi Int J Med

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Background: Life style change is considered as a factor affecting on the increasing number of subjects with peptic ulcer disease (PUD). Helicobacter pylori (H. pylori) infection is regarded as a risk factor for the mentioned disease. Objectives: This study aims to analyze the prevalence of PUD in asymptomatic subjects referring to the checkup clinic of Razavi Hospital and the relation between PUD and H. pylori. Materials and Methods: 499 asymptomatic subjects who had referred to the CheckUp Clinic of Razavi Hospital from 2006 till 2011 included in this study. Their data including: age, sex, endoscopy report and rapid urease test (RUT) were evaluated and the results of 260 Biopsy were analyzed by SPSS. Results: The mean age of the subjects was 52 which included 73.1% males and 26.9% females. Positive H. Pylori were reported in 75.2% of males and 24.8% of females. Endoscopy results revealed 57.2% subjects with PUD from which 23% were seen with erosion, 11.6% with gastritis, 11.4% with ulcer, 8% with erythema, 1.6% with sub epithelial hemorrhage, 0.8% with deodenitis and 0.8% with gastroduodenitis. In 72% of subjects that their endoscopy showed PUD and in 38% of the subjects with normal endoscopy, positive RUT was reported. There was a significant relation between PUD observed in endoscopy and RUT (P = 0.001). In 89.6% of subjects who had PUD in biopsy, 57.7% subjects had gastritis with positive H. pylori and 13.8% subjects had gastritis without H. Pylori. There was a significant relation between gastritis incidence based on biopsy and RUT (P = 0.001). Conclusions: The prevalence of PUD is more common in asymptomatic males than females. Regarding the high prevalence of PUD and H. pylori in the population under study and according to other studies, life style change and healthy nutrition are considered as effective factors in PUD prevention. According to the results of this study, the patients with upper GI symptoms should be suspect to PUD and positive H. pylori infection.

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Helicobacter Pylori Infection in Peptic Ulcer Disease

Cited by 7 publications

References 242 publications

Association of dupA, iceA, homB Genes of Helicobacter pylori with Gastritis, Peptic Ulcer Disease and Gastric Cancer

Association of dupA, iceA, homB Genes of Helicobacter pylori with Gastritis, Peptic Ulcer Disease and Gastric Cancer

Helicobacter pylori Infection in Peptic Ulcer Disease among Young People

Prevalence of Peptic Ulcer Disease in Asymptomatic Subjects Referring to the Check- Up Clinic of Razavi Hospital from 2006 - 2011

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